Adhesion of Thymocytes to the Thymic Epithelial Cells and Participation of Neyropilin-1 and Plexin A1 in the Adhesion

Rutto, K. V.; Kudryavtsev, I. V.; Kisseleva, E. P.

doi:10.1134/s1990519x18050073

Cited by 1 publication

(1 citation statement)

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“…It has been shown on diff erent non-immune cell types that Nrp-1 interacts with integrins (beta1, αVβ3 and α5β1) and other adhesion molecules (e.g., L1-CAM, L1-cell adhesion molecule) located laterally on the membrane of the same cell, and by doing so, aff ects the processes of adhesion to extracellular matrix and migration [3,9,32]. In the immune system, Nrp-1 and PlexA1, also independently of the presence of semaphorin 3A, participate in the thymocyte adhesion to mouse thymic epithelial cells [33].…”

Section: Receptor Functions Unrelated To Semaphorin 3amentioning

confidence: 99%

Semaphorin 3A in the Immune System: Twenty Years of Study

Kiseleva

Rutto

2022

Biochemistry Moscow

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Semaphorin 3A is a secreted glycoprotein, which was originally identifi ed as axon guidance factor in the neuronal system, but it also possesses immunoregulatory properties. Here, the eff ect of semaphorin 3A on T-lymphocytes, myeloid dendritic cells and macrophages is systematically analyzed on the bases of all publications available in the literature for 20 years. Expression of semaphorin 3A receptors -neuropilin-1 and plexins A -in these cells is described in details. The data obtained on human and murine cells is described comparatively. A comprehensive overview of the interaction of semaphorin 3A with mononuclear phagocyte system is presented for the fi rst time. Semaphorin 3A signaling mostly results in changes of the cytoskeletal machinery and cellular morphology that regulate pathways involved in migration, adhesion, and cell-cell cooperation of immune cells. Accumulating evidence indicates that this factor is crucially involved in various phases of immune responses, including initiation phase, antigen presentation, eff ector T cell function, infl ammation phase, macrophage activation, and polarization. In recent years, interest in this fi eld has increased signifi cantly because semaphorin 3A is associated with many human diseases and therefore can be used as a target for their treatment. Its involvement in the immune responses is important to study, because semaphorin 3A and its receptors turn to be a promising new therapeutic tools to be applied in many autoimmune, allergic, and oncology diseases.

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