Adhesion of surgical dressings to wounds. A new invitro model

Andrews, E. H.; Kamyab, I.

doi:10.1016/s0267-6605(86)80058-0

Cited by 12 publications

(9 citation statements)

References 7 publications

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“…The molecular structure of gelatin has C=O groups, and the gelatin test is a suitable way to evaluate the adherence to a hydrogen-bonding gel forming material. 33 Compared to PCL, WBPU has more C=O groups (dipole-dipole) in the polymer Figure 5 The measurement of maximum tension force of the tenton and percent molecular weight remaining of Pcl and PU at 4 weeks postsurgery. Notes: (A) Maximum tension force of the tendon for the normal, the untreated control, and the group treated with PCL, commercial product (Seprafilm), or PU3 after 4 weeks in vivo.…”

Section: Discussionmentioning

confidence: 99%

Evaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion

Hsu¹,

Dai²,

Hung³

et al. 2018

IJN

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BackgroundTendon adhesion is a serious problem and it affects tendon gliding and joint motion. Although recent studies have yielded promising results in developing anti-adhesion materials, there are still many problems. Polycaprolactone (PCL)-based polyurethane (PU) has good mechanical properties and biocompatibility, and it has a potential in anti-adhesion applications.Materials and methodsIn this study, a series of waterborne biodegradable polyurethane (WBPU) films with different ratios of ionic groups were synthesized. In order to select an effective anti-adhesion film, the WBPU films were cast and characterized for physicochemical properties and biocompatibility.ResultsAll WBPU films were non-cytotoxic in the cell viability test and had suitable physicochemical and mechanical properties based on the measurement of zeta potential, water contact angle, mechanical properties, water absorption, thickness change, and gelatin test. To evaluate the anti-adhesion effect, severely injured tendons of rabbits were sutured with the modified Kessler core suture technique and WBPU films were then wrapped around the tendon. Implantation in rabbits showed that the WBPU film had better anti-adhesion effect than PCL films and the untreated control, and demonstrated no significant difference in the anti-adhesion performance from the commercial product Seprafilm based on gross evaluation, histological analysis, and biomechanical assessment.ConclusionCompared to Seprafilm and PCL applied in the tendon anti-adhesion, WBPU had better mechanical properties, low inflammatory reaction, and a proper degradation interval.

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Section: Discussionmentioning

confidence: 99%

Evaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion

Hsu¹,

Dai²,

Hung³

et al. 2018

IJN

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“…Initially <25% RH was used to follow the previously reported procedure. 103 As the gelatin dried out at this lower humidity, the peeling energy kept increasing rapidly with the continuous loss of water in gelatin, reaching as high as 4491. In this wet-gelatin model, the gelatin slab is completely hydrated at the outset, surrounded by water molecules either at a dry or moist environment.…”

Section: Adherence Evaluationmentioning

confidence: 98%

“…Adaption of the wet-gelatin model for adherence evaluation.An in vitro wet-gelatin model was chosen to mimic the environment between human skin and wound dressing 103. Briefly, a polytetrafluoroethylene (PTFE) window frame with an open area 16×60 mm2 for gelatin casting wad created.…”

mentioning

confidence: 99%

“…Adherence of wound dressings is one of the most important factors influencing the wound healing and regeneration. Cell adhesion test has been considered as the most popular method to evaluate the adherence of dressing materials, but it fails to reflect the real situation during wound healing.In this study, an in vitro easily-handled peeling model based on gelatin is adapted to evaluate the adherence of PET dressings 103. As a proteinaceous material, gelatin can be used as an in vitro simulant of the in vivo protein-rich wound surface.…”

mentioning

confidence: 99%

“…More important, the crosslinked macromolecular network of hydrogel can serve as a reservoir to deliver drugs to wound sites, achieving a both non-adherent and antibacterial wound dressing. An in vitro gelatin model for dressing adherence evaluation overcomes the disadvantages associated with traditionally cell adhesion test or in vivo test which can be expensive, time-consuming, and sometimes ethically questionable as a screening tool 103. CHAPTER 2.…”

mentioning

confidence: 99%

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Effect of hydrogel grafting, water and surfactant wetting on the adherence of PET wound dressings

Ning

Logsetty

Ghughare

et al. 2014

Burns

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Traditional wound dressings, including cotton gauze, absorbent pads and bandages, can cause trauma and pain to wounds during dressing changes, leading to a variety of physical and psychosocial sequelae. The aim of this study was to adapt an in vitro model of adherence to evaluate the effects of various methods to theoretically reduce the adherence of wound dressings. Gelatin in liquid form was cast onto poly(ethylene terephthalate) (PET) fabric and allowed to solidify and progressively dry to simulate wound desiccation in the clinical setting. A 180° peel test of PET from the gelatin slab yielded adherence data of peeling energy. The peeling energy of PET increased with the drying time. It was possible to reduce the force by drying at 75% relative humidity (RH). After drying for 24h, either 500μL of water or surfactant solution was added onto the PET surface (16×60mm(2)). The peeling energy decreased dramatically with wetting and there was no significant difference between water and surfactant. As a long-term strategy for decreasing adherence, a thin layer of polyacrylamide (PAM) hydrogel was deposited onto PET fabric via UV irradiation. This resulted in a much lower peeling energy without severely compromising fabric flexibility. This hydrogel layer could also serve as a reservoir for bioactive and antimicrobial agents which could be sustainably released to create a microbe-free microenvironment for optimized wound healing.

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Characterization of surgical adhesives from UV‐polymerized poly(PEG dimethacrylate‐co‐2‐hydroxyethyl methacrylate) copolymers

Berkowicz

Peppas

1995

J of Applied Polymer Sci

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SYNOPSISPolymer samples that could be used as wound adhesives were prepared from poly(ethy1ene glyco1)dimethacrylate (PEGDMA) and 2-hydroxyethyl methacrylate (HEMA) copolymers in concentrations from 0 to 50 mol %. The UV copolymerization was initiated by 2,2-dimethoxy-2-phenylacetophenone (DMPA) and ultraviolet light intensities ranged from 0.1 to 0.5 mW/cm2. The volume shrinkage during photopolymerization was observed using a dilatometric technique. The overall volume shrinkage was affected by the comonomer ratio and the nature of the PEGDMA comonomer. The rate of volume shrinkage was higher at higher ultraviolet light intensities. PEG(400)DMA-based copolymers exhibited lower glass transition temperatures than those of PEG(2OO)-based copolymers. The introduction of HEMA to the copolymers reduced both their glass transition and degradation temperatures. The equilibrium water-swelling ratio increased with increasing PEGDMA molecular weight and HEMA content. 0 1995 John Wiley & Sons, Inc.

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Adhesion of surgical dressings to wounds. A new invitro model

Cited by 12 publications

References 7 publications

Evaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion

Evaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion

Effect of hydrogel grafting, water and surfactant wetting on the adherence of PET wound dressings

Characterization of surgical adhesives from UV‐polymerized poly(PEG dimethacrylate‐co‐2‐hydroxyethyl methacrylate) copolymers

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