Adhesion of soluble fibronectin, vitronectin, and collagen type IV to intraocular lens materials

Abstract

Each IOL material had a different affinity to each protein. Significant binding to 1 protein does not indicate that the IOL will bind significantly to all proteins; instead, each protein should be studied separately. Fibronectin bound significantly better to hydrophobic acrylate IOLs than to hydrophilic acrylate IOLs, suggesting that the HEMA-containing IOLs should be classified with the hydrogel IOL group.

Optical coherence tomography assessment of capsule closure after cataract surgery

“…Subsequently, the capsule adheres to the IOL optic by extracellular matrix components such as fibronectin and laminin. [1][2][3] Later, by transdifferentiation of anterior capsule lens epithelial cells (LECs) to myofibroblasts and laying down of collagen, the adhesion of the capsule to the optic becomes permanent.…”

Impact of fibronectin on surface properties of intraocular lenses

“…In these studies, the adsorption of FN to the IOL surface has been described as a reaction taking place within the aqueous humour [7,8,[16][17][18][19], and in one study, the in vitro adhesion of soluble FN has been analyzed as a function of IOL material in a series of different IOL types [17]. In this work, FN adsorbed significantly better to acrylate IOLs as well as to PMMA IOLs when compared to silicone IOLs.…”

“…After insertion, the implant surface is rapidly adsorbed with host factors. The importance of the balance between three factors for the initial phase of bacterial adhesion, i.e., physicochemical forces, bacterial surface characteristics (e.g., defined by capsular polysaccharides), and the presence of adsorbed host proteins has been previously addressed [17]. Accordingly, chemical modifications of IOL material may result in surface physics, e.g., towards more hydrophilic conditions, which may be less prone to bacterial interactions.…”

Cell Adhesion and Glistening Formation in Hybrid Copolymer Intraocular Lenses

“…Other researchers have also reported that although hydrophobic IOLs develop and bind adhesive molecules such as vitronectin and collagen type IV less than hydrophilic IOLs, hydrophobic IOLs showed much more fibronectin binding on their surface than hydrophilic IOLs [9]. It has also been reported, finally, that biofilm formation occurs on various IOLs but the extent of the bacterial adhesion and bacterial biofilm binding to the optics differs with the IOL material, increasing in the order hydrophilic acrylic polymer, polymethylmethacrylate, hydrophobic acrylic and silicone [10].…”