Adhesion of osteoblasts to a nanorough titanium implant surface

Gongadze, Ekaterina; Kabaso, Doron; Bauer, Sebastian; Slivnik, T.; Schmuki, Patrik; Rienen, Ursula van; Iglič, Aleš

doi:10.2147/ijn.s21755

Cited by 70 publications

(40 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, Gongadze et al demonstrated that titanium implants with low values of the surface potential promote osteoblast adhesion and the formation of the new bone [66]. The extensive review of Guo et al [38] demonstrates that the bone cell adhesion on a biomaterial and the initial stage of bone proliferation are quite sensible to the surface charge and its polarity.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Biocompatibility of Si Alloyed Multi-Principal Element Carbide Coatings

et al. 2016

View full text Add to dashboard Cite

In the current study, we have examined the possibility to improve the biocompatibility of the (TiZrNbTaHf)C through replacement of either Ti or Ta by Si. The coatings were deposited on Si and 316L stainless steel substrates by magnetron sputtering in an Ar+CH4 mixed atmosphere and were examined for elemental composition, chemical bonds, surface topography, surface electrical charge and biocompatible characteristics. The net surface charge was evaluated at nano and macroscopic scale by measuring the electrical potential and work function, respectively. The biocompatible tests comprised determination of cell viability and cell attachment to the coated surface. The deposited coatings had C/(metal+Si) ratios close to unity, while a mixture of metallic carbide, free-carbon and oxidized species formed on the film surface. The coatings’ surfaces were smooth and no influence of surface roughness on electrical charge or biocompatibility was found. The biocompatible characteristics correlated well with the electrical potential/work function, suggesting a significant role of surface charge in improving biocompatibility, particularly cell attachment to coating's surface. Replacement of either Ti or Ta by Si in the (TiZrNbTaHf)C coating led to an enhanced surface electrical charge, as well as to superior biocompatible properties, with best results for the (TiZrNbSiHf)C coating.

show abstract

Section: Discussionmentioning

confidence: 99%

In Vitro Biocompatibility of Si Alloyed Multi-Principal Element Carbide Coatings

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Studies have shown that osteoblasts proliferate better on surfaces stiffer than most polymers 84 as well as that mesenchymal stem cells (MSCs) differentiate into neurons on soft surfaces and osteoblasts on the stiff ones 85 , which explains how come the dispersion of CAP particles throughout a polymeric matrix leads to an increased Young’s modulus and increased bioactivity of the composite material at the same time 86 . Moreover, it is a rule of thumb that biomaterials in general should be rough so as to promote cell attachment 87,88 , except in a few cases, including joint and some soft tissue implants for which smooth surfaces are more desirable; impregnation of polymers with inorganic nanoparticles contributes to this surface roughness and makes additional processing steps such as etching or sandblasting unnecessary. Precipitation of HAp throughout an acellular dermal matrix at low supersaturation, the process which is also known as biomimetic mineralization of scaffolds, has correspondingly yielded a markedly more viable surface for the proliferation of periodontal ligament stem cells 89 .…”

Section: Polymeric/cap Compositesmentioning

confidence: 99%

When 1 + 1 > 2: Nanostructured composites for hard tissue engineering applications

Uskoković

2015

Materials Science and Engineering: C

View full text Add to dashboard Cite

Multicomponent, synergistic and multifunctional nanostructures have taken over the spotlight in the realm of biomedical nanotechnologies. The most prospective materials for bone regeneration today are almost exclusively composites comprising two or more components that compensate for the shortcomings of each one of them alone. This is quite natural in view of the fact that all hard tissues in the human body, except perhaps the tooth enamel, are composite nanostructures. This review article highlights some of the most prospective breakthroughs made in this research direction, with the hard tissues in main focus being those comprising bone, tooth cementum, dentin and enamel. The major obstacles to creating collagen/apatite composites modeled after the structure of bone are mentioned, including the immunogenicity of xenogeneic collagen and continuously failing attempts to replicate the biomineralization process in vitro. Composites comprising a polymeric component and calcium phosphate are discussed in light of their ability to emulate the soft/hard composite structure of bone. Hard tissue engineering composites created using hard material components other than calcium phosphates, including silica, metals and several types of nanotubes, are also discoursed on, alongside additional components deliverable using these materials, such as cells, growth factors, peptides, antibiotics, antiresorptive and anabolic agents, pharmacokinetic conjugates and various cell-specific targeting moieties. It is concluded that a variety of hard tissue structures in the body necessitates a similar variety of biomaterials for their regeneration. The ongoing development of nanocomposites for bone restoration will result in smart, theranostic materials, capable of acting therapeutically in direct feedback with the outcome of in situ disease monitoring at the cellular and subcellular scales. Progress in this research direction is expected to take us to the next generation of biomaterials, designed with the purpose of fulfilling Daedalus’ dream - not restoring the tissues, but rather augmenting them.

show abstract

“…15 Irrespective of the location of an implant (a blood-contacting, orthopaedic or dental implant) the first step made after the implantation is the adsorption of proteins from the surrounding tissue or medium. Gongadze et al [16][17][18] proposed a mechanism for the adhesion of the cells to a nanorough titanium implant surface with sharp edges, exhibiting more surface area and electric charge than a micro-sized surface. These surface characteristics of a contact surface affect the functional activity of cells.…”

Section: Introductionmentioning

confidence: 99%