Adhesion of Human Probiotic<i>Lactobacillus rhamnosus</i>to Cervical and Vaginal Cells and Interaction with Vaginosis-Associated Pathogens

Coudeyras, Sophie; Jugie, Gwendoline; Vermerie, Marion; Forestier, Christiane

doi:10.1155/2008/549640

Cited by 69 publications

(45 citation statements)

References 22 publications

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“…These findings are supported by the study of Coudeyras et al. [24] who observed anticandidal activity of a L. rhamnosus strain, when C. albicans was grown in liquid co‐culture with this strain. Furthermore, Rönnqvist et al.…”

Section: Probiotics For Prevention and Treatment Of Vulvovaginal Candsupporting

confidence: 79%

Potential role of probiotic bacteria in the treatment and prevention of localised candidosis

Mailänder-Sánchez

Wagener

Schaller

2011

Mycoses

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The extensive use of immunosuppressive therapies in recent years has increased the number of patients prone to or actually suffering from localised candidosis. As Candida species gain increasing resistance towards common antifungal drugs, new strategies are needed to prevent and treat infections caused by these pathogens. Probiotic bacteria have been in vogue in the past two decades. More and more dairy products containing such organisms offer promising potential beneficial effects on human health and well-being. Because of the ability of probiotic bacteria to inhibit the growth of pathogens and to modulate human immune responses, these bacteria could provide new possibilities in antifungal therapy. We summarise the recent findings concerning the usefulness of probiotic treatment in localised candidosis, as well as discussing possible risks of probiotic treatment and highlighting the molecular mechanisms that are believed to contribute to probiotic effects.

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Section: Probiotics For Prevention and Treatment Of Vulvovaginal Candsupporting

confidence: 79%

Potential role of probiotic bacteria in the treatment and prevention of localised candidosis

Mailänder-Sánchez

Wagener

Schaller

2011

Mycoses

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“…The vaginal mucosa is colonized by bacteria, especially Lactobacilli species [40]. Suppression of fungal growth by Lactobacilli has been documented in several studies [40,48–50]. The significance of these observations is reflected in the augmented risk of vaginal Candida infections from systemic antibacterial antibiotic therapy [33].…”

Section: Multi-species Interactions In Biofilm Formationmentioning

confidence: 99%

Mucosal biofilms of Candida albicans

Ganguly

Mitchell

2011

Current Opinion in Microbiology

174

125

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Biofilms are microbial communities that form on surfaces and are embedded in an extracellular matrix. C. albicans forms pathogenic mucosal biofilms that are evoked by changes in host immunity or mucosal ecology. Mucosal surfaces are inhabited by many microbial species; hence these biofilms are polymicrobial. Several recent studies have applied paradigms of biofilm analysis to study mucosal C. albicans infections. These studies reveal that the Bcr1 transcription factor is a master regulator of C. albicans biofilm formation under diverse conditions, though the most relevant Bcr1 target genes can vary with the biofilm niche. An important determinant of mucosal biofilm formation is the interaction with host defenses. Finally, studies of interactions between bacterial species and C. albicans provide insight into the communication mechanisms that endow polymicrobial biofilms with unique properties.

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“…The capacity that lactobacilli have to adhere and compete for adhesion sites in the vaginal epithelium (Zárate and Nader‐Macias ; Coudeyras et al . ) and the capacity to produce antimicrobial compounds, for example hydrogen peroxide (Aslim and Kilic ; Wasiela et al . ), lactic acid (Fraga et al .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of characteristics ofPediococcusspp. to be used as a vaginal probiotic

et al. 2013

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Aims: The aim of our research was to select, identify and characterize an isolate of lactic acid bacteria to be considered as a vaginal probiotic. Methods and Results: Thirty-five isolates of Pediococcus spp. showed bacteriocinogenic activity against Listeria monocytogenes and the ability to survive in simulated vaginal fluid (SVF) at pH 4Á2. One isolate of Pediococcus spp. was selected and characterized to evaluate its safety before the use as vaginal probiotic. Pediococcus pentosaceus SB83 did not show the presence of virulence factors such as the production of gelatinase, lipase and DNase, haemolytic activity, nor the presence of virulence genes (genes esp, agg, gelE, efaAfm, efaAfs, cylA, cylB and cylM). Pediococcus pentosaceus SB83 was considered sensitive to chloramphenicol, gentamicin, streptomycin, kanamycin, erythromycin and ampicillin. This strain was considered resistant to tetracycline and vancomycin. Pediococcus pentosaceus SB83 was a biofilm producer at different pH values (4Á2, 5Á5 and 6Á5) in SVF and in de Man, Rogosa and Sharpe medium. Conclusions: The in vitro results provide a basis for the use of P. pentosaceus SB83 as a vaginal probiotic, to prevent colonization by L. monocytogenes in pregnant women. Significance and Impact of Study: The application of vaginal probiotics could have the potential for preventing vaginal infections and consequently reduce abortion and neonatal infections.

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Adhesion of Human ProbioticLactobacillus rhamnosusto Cervical and Vaginal Cells and Interaction with Vaginosis-Associated Pathogens

Cited by 69 publications

References 22 publications

Potential role of probiotic bacteria in the treatment and prevention of localised candidosis

Potential role of probiotic bacteria in the treatment and prevention of localised candidosis

Mucosal biofilms of Candida albicans

Evaluation of characteristics ofPediococcusspp. to be used as a vaginal probiotic

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