Adhesion molecules as a prognostic marker of liver cirrhosis

Abstract

In addition to the classic factor implicated in mortality (Child-Pugh class), alterations in inflammation-related components and soluble adhesion molecules, as representatives of hemodynamic alterations, are of prognostic significance in cirrhotic patients.

Elevated Soluble Tumor Necrosis Factor Receptor 75 Concentrations Identify Patients With Liver Cirrhosis at Risk of Death

“…These observations are in line with 2 recent studies that also highlighted the predictive value of sTNF-R 75 levels as an independent risk factor for cirrhotic patients. 42,43 However, these studies were either focused on short-term survival (3 months) or did not evaluate the value of sTNF-Rs in comparison with MELD. 42,43 Furthermore, we made some additional observations.…”

“…42,43 However, these studies were either focused on short-term survival (3 months) or did not evaluate the value of sTNF-Rs in comparison with MELD. 42,43 Furthermore, we made some additional observations. Presence of elevated sTNF-R 75 levels or a high MELD score markedly reduced false-negative rates compared with single tests, which is clinically relevant especially for the decision whether to refer a patient for liver transplantation.…”

α‐Melanocyte‐stimulating hormone gene therapy reverses carbon tetrachloride induced liver fibrosis in mice

“…Cell adhesion molecules are known as prognostic markers of liver fibrosis [43]. The expressions of ICAM-1 and VCAM-1, modulated by TNF-α, are upregulated in alcoholic hepatitis, CCl 4 -induced liver injury, and nutritional fibrosis [44][45][46].…”

Natural history and prognostic indicators of survival in cirrhosis: A systematic review of 118 studies

“…Only one study fulfilled all quality criteria [39]. Thirty-one studies met our criteria for a 'good' quality study [32,37,39,47,55,57,60,62,63,66,76,81,85,89,92,[95][96][97]100,103,104,112,116,117,123,124,128,130,138,142,143]. …”