Adhesion G protein-coupled receptor G2 accelerates the proliferation of cancer cells by promoting the formation of CDK4/CCND1

Abstract

Gastric cancer is a common malignant tumor in humans. Analysis of clinical data of gastric cancer revealed that adhesion G protein-coupled receptor G2 (ADGRG2), endoplasmic reticulum oxidoreductase 1β, lactate dehydrogenase B and chromosome 1 open reading frame 115 were abnormally highly expressed in gastric cancer. ADGRG2 was not only highly expressed in gastric cancer tissues, but was also associated with poor prognosis in patients with gastric cancer. Numerous oncogenes and tumor suppressor genes are directly involved in the regulation of the cell cycle. ADGRG2 was shown to promote cell proliferation by promoting the G1/S transition. ADGRG2 did not affect the expression of CDK4 or cyclin D1 (CCND1), but was found to affect the cell cycle by promoting the formation of the cell cycle-dependent complex CDK4/CCND1, thereby promoting cell proliferation, and affecting the formation and development of gastric cancer.

hsa_circ_0131457 regulates SFRP2 through miR-636 to inhibit the invasion and metastasis of pancreatic cancer

“…Overexpression of hsa_circ_0000662 and has_circ_0086375 inhibits the proliferation and invasion of pancreatic cancer cells, induces cell apoptosis, and thereby inhibits tumor growth [9][10]. The up-regulated expression level of hsa_circ_0006988 in pancreatic cancer tissues and plasma is associated with clinical stage, lymph node invasion, and distant metastasis, making it a potential molecular marker for prognosis evaluation [11]. Additionally, certain combinations of cirRNA signals have shown potential in improving the sensitivity and specificity of early pancreatic cancer diagnosis, as well as improving prognosis and quality of life.…”