Adhesio interthalamica in individuals at high-risk for developing psychosis and patients with psychotic disorders

Takahashi, Tsutomu; Yücel, Murat; Yung, Alison R.; Wood, Stephen J.; Phillips, Lisa; Berger, Gregor; Ang, Anthony; Soulsby, Bridget; McGorry, Patrick D.; Suzuki, Michio; Velakoulis, Dennis; Pantelis, Christos

doi:10.1016/j.pnpbp.2008.07.007

Cited by 33 publications

(23 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, it seems consistent with the result of studies performed by Meisenzahl[3132] and Takahashi,[39] who perceived that patients without AI structure are more prone to have negative symptoms (prominent symptoms of residual subtype of schizophrenia) than patients with AI.…”

Section: Discussionsupporting

confidence: 90%

“…Snyder et al .,[34] confined this structural difference only to patients with first episode of schizophrenia and excluded the chronic patients. In contrast, Takahashi et al .,[39] reported that the absence of the AI was more common in patients with chronic schizophrenia, when compared to first-episode psychosis and Meisenzahl[3132] and Takahashi[39] stated that the absence of AI may be associated with more severe negative symptoms (that are mostly observed in chronic patients). They claimed that patients with schizophrenia may manifest progressive brain changes, including atrophy of AI following the onset.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A magnetic resonance imaging study of adhesio interthalamica in clinical subtypes of schizophrenia

Haghir

Mokhber

Azarpazhooh

et al. 2013

Indian J Psychiatry

View full text Add to dashboard Cite

Context:Previous studies have suggested subtle anatomical brain differences between patients with schizophrenia and healthy control subjects. However, the results are inconsistent and there is no study investigating the various subtypes of this mental disorder separately.Aim:This study was conducted to compare the rate of absence of adhesio interthalamica (AI), a midline brain structure, between 3 subtypes of schizophrenia (paranoid, undifferentiated, and residual) and healthy control group, using magnetic resonance imaging (MRI).Materials and Methods:A total of 29 schizophrenia patients (21 men, 8 women) of three subtypes (paranoid, undifferentiated, and residual) were compared with 29 age- and gender-matched healthy controls. All subjects underwent 3-D brain MRI of full coronal series, 1.5-mm slices without interslice gaps. If the grey matter band connecting the thalami could not be identified on two or more coronal adjacent slices, the AI was considered as absent. The results were statistically analyzed.Results:The incidence rate of AI absence in patients with heterogenous subtypes of schizophrenia was was similar to control group, even when patients and controls of each gender were compared separately (P>0.05). In residual subtype, patients showed a significant priority in AI absence in comparison with the control group (P=0.041), which was not seen in paranoid and undifferentiated subtypes (P>0.05).Conclusion:Residual subtype of schizophrenia is associated with higher rate of AI absence in this study. Subsequent studies are required to determine if the absence of AI is a cause of residual schizophrenia or an effect.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

A magnetic resonance imaging study of adhesio interthalamica in clinical subtypes of schizophrenia

Haghir

Mokhber

Azarpazhooh

et al. 2013

Indian J Psychiatry

View full text Add to dashboard Cite

show abstract

“…Volunteers of the SP category showed a significant larger interthalamic adhesion than the subjects in the DP group, while those in the XP group had no interthalamic adhesion. Both size and incidence of absent interthalamic adhesion in our study group agree well with published data for healthy controls in the literature (Nopoulos et al, 2001;Takahashi et al, 2008).…”

Section: Sp Dp Xpsupporting

confidence: 91%

Insight into the patterns of cerebrospinal fluid flow in the human ventricular system using MR velocity mapping

et al. 2010

View full text Add to dashboard Cite

“…Nevertheless, the higher incidence of an absent AI in chronic psychosis reported in the literature (Trzesniak et al 2011b) might be explained by the fact that the AI was shown to be already shorter at the onset of psychosis. Several studies have shown associations between measurements of AI and LV in samples of controls and psychosis patients (Snyder et al 1998;Meisenzahl et al 2002;Takahashi et al 2008 c), which is in line with the suggestion that the AI develops jointly with important components of the ventricular system during early gestation (Rosales et al 1968).…”

Section: Follow-up Evaluationsupporting

confidence: 65%

Longitudinal follow-up of cavum septum pellucidum and adhesio interthalamica alterations in first-episode psychosis: a population-based MRI study

et al. 2012

View full text Add to dashboard Cite

Our findings suggest that the CSP per se may not be linked to the neurobiology of emerging psychotic disorders, although it might be related to the progression of the disease. However, the fact that the AI length was shown to be shorter at the onset of the disorder supports the neurodevelopmental model of schizophrenia and indicates that an alteration in this grey matter junction may be a risk factor for developing psychosis.

show abstract

Adhesio interthalamica in individuals at high-risk for developing psychosis and patients with psychotic disorders

Cited by 33 publications

References 31 publications

A magnetic resonance imaging study of adhesio interthalamica in clinical subtypes of schizophrenia

A magnetic resonance imaging study of adhesio interthalamica in clinical subtypes of schizophrenia

Insight into the patterns of cerebrospinal fluid flow in the human ventricular system using MR velocity mapping

Longitudinal follow-up of cavum septum pellucidum and adhesio interthalamica alterations in first-episode psychosis: a population-based MRI study

Contact Info

Product

Resources

About