Adherent perinephric fat affects perioperative outcomes after partial nephrectomy: a systematic review and meta-analysis

Khene, Z.; Dosin, G.; Peyronnet, B.; Gasmi, Anis; Doumerc, N.; Ouzaïd, I.; Pradère, Benjamin; Brassier, M.; Roumiguié, M.; Mathiéu, Romain; Rioux‐Leclercq, Nathalie; Raman, Jay D.; Shariat, Shahrokh F.; Bensalah, Karim

doi:10.1007/s10147-021-01871-6

Cited by 12 publications

(7 citation statements)

References 24 publications

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“…295 – 297 Of note, ccRCC can invade into surrounding perinephric adipose tissue (PAT), which distributes between the renal capsule and renal fascia, and this process is associated with some adverse perioperative outcomes and poor prognosis. 298 – 300 Given that cancers are capable of reprogramming noncancerous neighboring cells to fuel tumor growth via providing additional nutrients, the potential protumorigenic relationship between ccRCC cells and PAT has been gradually studied in recent years. For example, recent research has shown that melatonin promotes tumor slimming and suppress tumor progression by activating transcriptional coactivator PGC1A and lipid browning programs.…”

Section: The Developmental Origin and Anatomical Location Of Thermoge...mentioning

confidence: 99%

The evolving view of thermogenic fat and its implications in cancer and metabolic diseases

Yin

Chen

Ruze

et al. 2022

Sig Transduct Target Ther

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The incidence of metabolism-related diseases like obesity and type 2 diabetes mellitus has reached pandemic levels worldwide and increased gradually. Most of them are listed on the table of high-risk factors for malignancy, and metabolic disorders systematically or locally contribute to cancer progression and poor prognosis of patients. Importantly, adipose tissue is fundamental to the occurrence and development of these metabolic disorders. White adipose tissue stores excessive energy, while thermogenic fat including brown and beige adipose tissue dissipates energy to generate heat. In addition to thermogenesis, beige and brown adipocytes also function as dynamic secretory cells and a metabolic sink of nutrients, like glucose, fatty acids, and amino acids. Accordingly, strategies that activate and expand thermogenic adipose tissue offer therapeutic promise to combat overweight, diabetes, and other metabolic disorders through increasing energy expenditure and enhancing glucose tolerance. With a better understanding of its origins and biological functions and the advances in imaging techniques detecting thermogenesis, the roles of thermogenic adipose tissue in tumors have been revealed gradually. On the one hand, enhanced browning of subcutaneous fatty tissue results in weight loss and cancer-associated cachexia. On the other hand, locally activated thermogenic adipocytes in the tumor microenvironment accelerate cancer progression by offering fuel sources and is likely to develop resistance to chemotherapy. Here, we enumerate current knowledge about the significant advances made in the origin and physiological functions of thermogenic fat. In addition, we discuss the multiple roles of thermogenic adipocytes in different tumors. Ultimately, we summarize imaging technologies for identifying thermogenic adipose tissue and pharmacologic agents via modulating thermogenesis in preclinical experiments and clinical trials.

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Section: The Developmental Origin and Anatomical Location Of Thermoge...mentioning

confidence: 99%

The evolving view of thermogenic fat and its implications in cancer and metabolic diseases

Yin

Chen

Ruze

et al. 2022

Sig Transduct Target Ther

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“…The RENAL Score was lower in the PSM group (PSM: 6 vs. NSM: 7, p = 0.05). The overall median follow-up was 19 9 , 36 months; 160 (7.4%) recurrences (88 local and 72 metastases) were reported: 9 (6.6%) in the PSM group and 151 (7.4%) in the NSM group.…”

Section: Resultsmentioning

confidence: 99%

“…We believe this cohort shows routine practice in university centers, where juniors are operating patients under seniors’ supervision so that EXP is a shallow concept. Finally, like numerous studies about RAPN, we lacked data concerning the length of the margin, the tumorectomy technique and the presence of adherent perinephric fat (APF), but these two last factors do not seem to be predictive of PSM in the literature 34 – 36 . We also lacked data for the treatment of the recurrence, and this treatment may have generated a selection bias by changing the results for MFS and OS.…”

Section: Discussionmentioning

confidence: 99%

Positive surgical margin’s impact on short-term oncological prognosis after robot-assisted partial nephrectomy (MARGINS study: UroCCR no 96)

Morrone

Bentellis

Bernhard

et al. 2022

Sci Rep

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The oncological impact of positive surgical margins (PSM) after robot-assisted partial nephrectomy (RAPN) is still under debate. We compared PSM and Negative Surgical Margins (NSM) in terms of recurrence-free survival (RFS), metastasis-free survival (MFS) and overall survival (OS) after RAPN, and we identified predictive factors of PSM. Multi-institutional study using the UroCCR database, which prospectively included 2166 RAPN between April 2010 and February 2021 (CNIL DR 2013-206; NCT03293563). Two groups were retrospectively compared: PSM versus NSM. Prognostic factors were assessed using Kaplan–Meyer curves with log-Rank test, cox hazard proportional risk model and logistic regression after univariate comparison. 136 patients had PSM (6.3%) and 2030 (93.7%) had NSM. During a median follow-up of 19 (9–36) months after RAPN, 160 (7.4%) recurrences were reported. Kaplan–Meier curves and analysis suggested that RFS, MFS and OS were not affected by a PSM (p = 0.68; 0.71; 0.88, respectively). In multivariate analysis predictors of PSM were a lower RENAL score (p = 0.001), longer warm ischemia time (WIT) (p = 0.003) and Chromophobe Renal Cell Carcinoma (chrRCC) (p = 0.043). This study found no impact of PSM on RFS, MFS or OS, and predictors of PSM were the RENAL score, WIT and chrRCC.

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“…En revanche son association avec la survenue de complications est plus débattue. Elle est fortement associée à la morbidité peropératoire (durée d'intervention, pertes sanguines, conversion, transfusion) mais pas ou peu avec les complications [21,22].…”

Section: La Graisse Adhérente Périrénaleunclassified

Les complications de la néphrectomie totale et de la néphrectomie partielle : quelles sont-elles, comment les prévenir et les prendre en charge ?

Bensalah

Pignot

Legeais³

et al. 2022

Progrès en Urologie

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Adherent perinephric fat affects perioperative outcomes after partial nephrectomy: a systematic review and meta-analysis

Cited by 12 publications

References 24 publications

The evolving view of thermogenic fat and its implications in cancer and metabolic diseases

The evolving view of thermogenic fat and its implications in cancer and metabolic diseases

Positive surgical margin’s impact on short-term oncological prognosis after robot-assisted partial nephrectomy (MARGINS study: UroCCR no 96)

Les complications de la néphrectomie totale et de la néphrectomie partielle : quelles sont-elles, comment les prévenir et les prendre en charge ?

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