Adhérences postopératoires et leur prévention en chirurgie gynécologique : II. Comment les prévenir ?

Pouly, Jean-Luc; Daraı̈, Émile; Yazbeck, Chadi; Bénifla, J.-L.; Déchaud, H.; Wattiez, Arnaud; Crowe, A. M.; Audebert, A

doi:10.1016/j.gyobfe.2011.10.001

Cited by 4 publications

(2 citation statements)

References 58 publications

(92 reference statements)

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“…They lead to significant clinical morbidities ranging from infertility, small bowel obstruction, pelvic pain, and future surgical complications ( 1 , 2 ). Several agents have been proposed to decrease their occurrence, including antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, fibrinolytics, reactive oxygen species (ROS) scavengers, calcium channel blockers, and GnRH analogs ( 3 ). Most of these agents have only been tested in animals, with some showing positive results; however, data from human trials are very limited.…”

Section: Introductionmentioning

confidence: 99%

“…They can be site-specific (mechanical) or broad-coverage (gel or fluid) agents ( 2 – 4 ). Although some of these agents effectively reduce postsurgical adhesions, their use has many drawbacks, including difficulty in applying such agents in open or laparoscopic surgeries, decrease in their efficacy in the presence of bleeding, need for special and complex equipment for their application, and the high cost of most of those agents ( 1 – 3 ). Natural membranes such as omentum or peritoneal membranes have also been used but owing to their immunogenicity, they cannot be an ideal heterograft ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

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Effect of the Mode of Application of Cryopreserved Human Amniotic Membrane on Adhesion Formation after Abdomino-Pelvic Surgery in a Mouse Model

et al. 2016

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Adhesions after abdomino-pelvic surgery are a cause of morbidity and reoperations. The use of human amniotic membrane (HAM) for adhesion prevention has given controversial results. The mode of administration of the amniotic membrane has not been well studied. This study assessed the efficacy of two modes of application of cryopreserved HAM, patch or fragmented in Lactated Ringer (LR) solution, for the prevention of pelvic adhesion formation postabdomino-pelvic surgery in a mice model. After a midline laparotomy incision, a small cautery lesion was done on each side of the abdominal wall peritoneum in mice. In Group A (control; n = 42), the abdomen was closed directly, Group B (n = 42) received 2.5 ml of LR prior to closure. In Groups C (n = 42) and D (n = 42), a 2 cm × 2 cm patch of HAM and another one fragmented and dispersed in 2.5 ml of LR were applied prior to closure, respectively. Two weeks later, a laparotomy was performed, and gross and pathological evaluation of adhesions, fibrosis, angiogenesis, and inflammation were conducted. Group D exhibited a significantly lower rate of gross adhesion formation. Fibrosis was significantly lowest in Group C as compared to the control. Group B had the lowest vascular formation in the adhesions. The use of HAM fragmented in LR solution is associated with a significantly lower incidence of postoperative adhesions in mice when compared to LR alone, HAM patch, or control. The mechanism of action of this reduction needs to be elucidated by future studies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of the Mode of Application of Cryopreserved Human Amniotic Membrane on Adhesion Formation after Abdomino-Pelvic Surgery in a Mouse Model

et al. 2016

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Surgicel for Prevention of Postoperative Adhesions in Laparoscopic Myomectomy: A Propensity Score-Matching Analysis

Osman

Mohamed

Ibrahim³

2022

Journal of Gynecologic Surgery

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A new bioabsorbable polymer film to prevent peritoneal adhesions validated in a post-surgical animal model

et al. 2018

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BackgroundPeritoneal adhesions are a serious surgical postoperative complication. The aim of this study is to investigate, in a rat model, the anti-adhesive effects of a bioabsorbable film of polymer combining polyethylene glycol and polylactic acid.Materials and methodsSixty-three animals were randomized into five groups according to the anti-adhesion treatment: Hyalobarrier®, Seprafilm®, Polymer A (PA), Polymer B (PB), and control. The rats were euthanized on days 5 and 12 to evaluate the extent, severity and degree of adhesions and histopathological changes. Three animals were euthanized at day 2 in PA, PB and control groups to observe the in vivo elimination.ResultsMacroscopic adhesion formation was significantly lower in the PA group than in the control group at day 5 (median adhesion score 0±0 vs 9.6 ±0.5 p = 0.002) and at day 12 (0±0 vs 7.3±4 p = 0.02). Furthermore, median adhesion score at day 5 was significantly lower in the PA group than in the Seprafilm group (0±0 vs 4.2± 3.9 p = 0.03). Residence time of PA seems longer than PB.ConclusionThe PA bioabsorbable film seems efficient in preventing the formation of peritoneal adhesions.

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Adhérences postopératoires et leur prévention en chirurgie gynécologique : II. Comment les prévenir ?

Cited by 4 publications

References 58 publications

Effect of the Mode of Application of Cryopreserved Human Amniotic Membrane on Adhesion Formation after Abdomino-Pelvic Surgery in a Mouse Model

Effect of the Mode of Application of Cryopreserved Human Amniotic Membrane on Adhesion Formation after Abdomino-Pelvic Surgery in a Mouse Model

Surgicel for Prevention of Postoperative Adhesions in Laparoscopic Myomectomy: A Propensity Score-Matching Analysis

A new bioabsorbable polymer film to prevent peritoneal adhesions validated in a post-surgical animal model

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