Adherence to treatment for polycystic ovarian syndrome: A systematic review

Parker, M.; Warren, Anna; Nair, Sonam; Barnard, Marie

doi:10.1371/journal.pone.0228586

Cited by 15 publications

(9 citation statements)

References 31 publications

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“…88 A review of studies in PCOS involving lifestyle intervention did not provide significant data on adherence to the programs in the majority of trials. 89 A detailed look at 4 randomized trials of lifestyle intervention in PCOS involving a total of 221 women showed attrition from the programs was 47.1%. However, weight loss of >5% occurred in 63% of the women.…”

Section: Meta-analysis Of Lifestyle Interventionsmentioning

confidence: 99%

Update on PCOS: Consequences, Challenges, and Guiding Treatment

Hoeger

Dokras

Piltonen

2020

The Journal of Clinical Endocrinology &Amp; Metabolism

319

179

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Polycystic Ovary Syndrome (PCOS) is one of the most common reproductive endocrine disorders in women and despite this, diagnostic challenges, delayed diagnosis and less than optimal treatment regimens plague the condition. The International PCOS network, consisting of geographically diverse international experts in PCOS as well as consumers, engaged in a multi-year international evidence-based guideline development process that was jointly sponsored by the European Society for Human Reproduction and Embryology (ESHRE) and the American Society of Reproductive Medicine (ASRM). The guideline was published in 2018 and endorsed by more than 40 international societies involved in PCOS. Translation of this evidence-based guideline to medical practice and consumer groups remains a priority. However, there remain many challenges to both understanding the diagnosis and treatment of PCOS. Evidence suggests that both clinicians and consumers are not satisfied with the timeliness of diagnosis and treatment options. This review summarizes the important findings for diagnosis and treatment from the guidelines and expands on recent developments in the literature since its publication. Special attention to diagnosis at the ends of the reproductive spectrum are discussed and remaining areas of controversy are noted. Additionally, the review highlights some of the remaining challenges in the understanding and management of PCOS to help guide clinicians and investigators in this perplexing condition.

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Section: Meta-analysis Of Lifestyle Interventionsmentioning

confidence: 99%

Update on PCOS: Consequences, Challenges, and Guiding Treatment

Hoeger

Dokras

Piltonen

2020

The Journal of Clinical Endocrinology &Amp; Metabolism

319

179

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“…Zingiber officinale Roscoe (ginger) from the family of Zingeiberaceae family lowers serum levels in fasting glucose, insulin, low-and high-density lipoprotein-cholesterols 21 . PCOS is connected with T2DM through obesity and insulin resistance and lower serum levels can lowers the disease 22 . Liao et al 23 performed herbs and herbal treatment in PCOS women through Jia-Wei-Xiao-Yao-San and Xing-Fu; were commonly used herb and these showed the positiveness towards the treatment in Taiwanese PCOS women.…”

Section: Introductionmentioning

confidence: 99%

Application of Herbal Medicines for Obesity Treatment in the Polycystic Ovarian Syndrome Women

Alghamdi¹

2020

J Pure Appl Microbiol

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Polycystic ovarian syndrome (PCOS) is a frequent disorder commonly found in reproductive-aged women. The disease PCOS in women is considered to be complex heterogeneity, which indicates the combined combination of genetics and environmental interaction factors. Insulin resistance, type 2 diabetes mellitus, and obesity are known to be the risk factors for the development of PCOS. The prevalence of obesity in Saudi Arabia is ripening equally in both men and women. Herbal Medicines are often used for the treatment of human diseases by traditional medicine. Herbal remedies are often used to treat PCOS women due to the similar effectiveness exists as Western anti-obesity drugs. This study aimed to acknowledge the usage of herbal medicines for the prevention of obesity in PCOS women. This is a cross-sectional study carried out in reproductive-aged women in the Saudi population. PCOS women were provided with the questionnaire form if they are using the herbal products for the treatment of obesity. In this study, 85 PCOS women with obesity have been selected. The clinical and usage of herbal details have been recorded. In this study, 70.5% of women were using green tea, 19.8% and 11.7% were using the ginger and flax seeds. Turmeric, Capsicum and fenugreeks were used by 25.8%, 4.7% and 18.8% respectively. In conclusion, the PCOS women has high usage of green tea rather than other herbal medicines.

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“…The standard treatment for PCOS addresses the menstrual irregularity and hyperandrogenism with oral contraceptive pills. At the same time, the metabolic features are managed with metformin, a drug used to reduce the blood sugar levels in T2DM patients [ 5 ]. Though these drugs are effective, the medication must still be taken regularly and may present mild to severe side effects.…”

Section: Introductionmentioning

confidence: 99%

Potential of Mesenchymal Stem Cells and Their Secretomes in Decreasing Inflammation Markers in Polycystic Ovary Syndrome Treatment: A Systematic Review

Prayitno

Lestari

Sartika³

et al. 2022

Medicines

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Background: Polycystic ovary syndrome (PCOS) is a chronic disorder and is one of the most common endocrine disorders in women of a reproductive age. The prevalence of PCOS is growing globally; 52% of women in Southeast Asia alone suffer from this disorder. This disorder is caused by chronic hyperandrogenism, which hinders folliculogenesis. There is also a close relationship between hyperandrogenism and hyperinsulinemia/insulin resistance (IR), and it is estimated that 40–80% of PCOS patients suffer from insulin resistance (IR). Mesenchymal stem cells (MSCs) and their secretomes have been shown to alleviate PCOS symptoms by decreasing IR and androgen secretion by reducing inflammation. This study aimed to systematically review the literature to study the reported potential of MSCs and their secretomes in decreasing inflammation markers in PCOS treatment. Methods: A systematic literature search was performed on EMBASE, PubMed (MEDLINE), and the Cochrane Library with the terms insulin-resistant PCOS, mesenchymal stem cells, and secretome or conditioned medium as the search keywords. A total of 317 articles were reviewed. Four articles were identified as relevant for this systematic review. Results: The results of this study supported the use of mesenchymal stem cells and their secretions in decreasing inflammatory markers in the treatment of polycystic ovary syndrome. Conclusions: This review provided evidence that treatment with mesenchymal stem cells and their secretomes has the potential to treat PCOS due to its ability to downregulate androgen levels and increase insulin sensitivity, which thereby lowers the level of proinflammatory factors.

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Adherence to treatment for polycystic ovarian syndrome: A systematic review

Cited by 15 publications

References 31 publications

Update on PCOS: Consequences, Challenges, and Guiding Treatment

Update on PCOS: Consequences, Challenges, and Guiding Treatment

Application of Herbal Medicines for Obesity Treatment in the Polycystic Ovarian Syndrome Women

Potential of Mesenchymal Stem Cells and Their Secretomes in Decreasing Inflammation Markers in Polycystic Ovary Syndrome Treatment: A Systematic Review

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