Adherence to Topical Medications for Chronic Rhinosinusitis: Medication Posession Ratio and Description of Adherence Barriers

Hines, Brittany; Lal, Devyani; Rank, Matthew A.; Lewis, Jason; Teaford, Harry G.

doi:10.1016/j.jaci.2015.12.1003

Cited by 1 publication

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“…This was a single-centre study, which may not provide a representative sample of the wider CRS population. For example, the average age for participants in this study was 60 years, which was higher than in other studies of CRS patients [7,[17][18][19]. This could be due to the local demographics of the study site or the fact that older participants may have been more likely to respond to the survey.…”

Section: Limitationsmentioning

confidence: 62%

Prevalence and Associated Factors of Medication Non-Adherence in CRS Patients following Endoscopic Sinus Surgery

Gokani,

Clark,

Javer

et al. 2023

JCM

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This study aimed to evaluate factors that may predispose patients to not adhere to prescribed medication after endoscopic sinus surgery (ESS) and to compare SNOT-22 scores at 0–12 months post-operatively between adherent and non-adherent patients. CRS patients who underwent ESS between 2012 and 2016 were recruited to this retrospective cohort study. Adherence was assessed through a questionnaire and review of medical notes. Ninety-four participants were included (61% male, mean age 60). Of those, 66% did not adhere to their prescribed post-operative CRS medication timing or dosage. The most common reason for non-adherence was improvement of symptoms (17%), followed by deterioration of symptoms (11%) and side effects (10%). Post-operative SNOT-22 scores were lowest for non-intentionally non-adherent (NINA) participants with a mean of 10.5 [95% CI: 7.47–13.5], compared to 25.0 for intentionally non-adherent (INA) [95% CI: 17.6–32.4] and 17.7 for adherent patients [95% CI: 13.7–21.7], p = 0.01. This study identifies that almost two-thirds of patients are not compliant with CRS medications after ESS. NINA participants reported lower post-operative SNOT-22 scores compared to INA and adherent participants. Future studies should focus on educating patients to continue with medications post-operatively despite an initial improvement in symptoms.

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Section: Limitationsmentioning

confidence: 62%