Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults

Chrysοhoou, Christina; Panagiotakos, Demosthenes B.; Pitsavos, Christos; Das, Undurti N.; Stefanadis, Christodoulos

doi:10.1016/j.jacc.2004.03.039

Cited by 669 publications

(467 citation statements)

References 27 publications

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“…The adherence to the traditional Mediterranean diet has been associated with a reduction in low-grade inflammatory status, better endothelial function, an improved profile of coagulation markers (Chrysohoou et al, 2004;Ló pez-Garcia et al, 2004), and less insulin resistance (MacKeown et al, 2004). All these factors are thought to lead not only to a lower risk of chronic diseases, but also to a better metabolic control of already established diseases.…”

Section: Discussionmentioning

confidence: 99%

Adherence to the Mediterranean diet and quality of life in the SUN Project

et al. 2011

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Background/Objectives: Mediterranean diet has been related with reduced morbidity and better well-being. The aim of this study was to assess whether the adherence to the Mediterranean diet were associated with mental and physical health related to quality of life. Subjects/Methods: This analysis included 11 015 participants with 4 years of follow-up in the SUN Project (a multipurpose cohort study based on university graduates from Spain). A validated 136-item food frequency questionnaire was used to assess the adherence to the Mediterranean diet at baseline, according to a nine-point score, presented in four categories (low, low-moderate, moderate-high and high). Health-related quality of life (HRQL) was measured after 4 years of follow-up with the Spanish version of the SF-36 Health Survey. Generalized Linear Models were fitted to assess adjusted mean scores, the regression coefficients (b) and their 95% confidence intervals (95% CIs) for the SF-36 domains according to categories of adherence to Mediterranean diet. Results: Multivariate-adjusted models revealed a significant direct association between adherence to Mediterranean diet and all the physical and most mental health domains (vitality, social functioning and role emotional). Vitality (b ¼ 0.50, 95% CI ¼ 0.32-0.68) and general health (b ¼ 0.45, 95% CI ¼ 0.26-0.62) showed the highest coefficients. Mean values for physical functioning, role physical, bodily pain, general health and vitality domains were significantly better with increasing adherence to the Mediterranean diet. Those having improved their initial high diet scores have better scores in physical functioning, general health and vitality. Conclusions: Adherence to the Mediterranean diet seems to be a factor importantly associated with a better HRQL.

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Section: Discussionmentioning

confidence: 99%

Adherence to the Mediterranean diet and quality of life in the SUN Project

et al. 2011

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“…Similar components are included in the traditional Mediterranean diet defined a priori by Trichopoulou et al (3) . The beneficial effects of the Mediterranean diet have been widely examined (3,4,(33)(34)(35) . Prospective studies such as the EPIC (European Prospective Investigation into Cancer and Nutrition)-Greek cohort have shown a decrease in mortality for all causes, CVD and cancer among subjects who follow this dietary pattern (3) .…”

Section: Discussionmentioning

confidence: 99%

Association between dietary and beverage consumption patterns in the SUN (Seguimiento Universidad de Navarra) cohort study

Sánchez‐Villegas

Toledo

Bes–Rastrollo

et al. 2008

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Objective: The objective of the present study was to determine the dietary patterns of a Mediterranean cohort and relate them to the observed patterns of beverage consumption. Design: Prospective cohort study. Dietary habits were assessed with a semiquantitative FFQ validated in Spain. A principal components factor analysis was used to identify dietary patterns and to classify subjects according to their adherence to these patterns. The association between adherence to each dietary pattern and beverage consumption was assessed cross-sectionally. In a longitudinal analysis (2-year follow-up), the relationship between adherence to the baseline dietary patterns and the likelihood of changing alcohol consumption was ascertained. Setting: The SUN (Seguimiento Universidad de Navarra) study is conducted in Spain. Subjects: In total, 15 073 university graduates were included in the analyses. Results: Two major dietary patterns were identified. We labelled them as 'Western dietary pattern' (WDP) and 'Mediterranean dietary pattern' (MDP). Higher adherence to the WDP was associated with higher consumption of carbonated beverages and whole-fat milk (P for trend ,0?001), while higher adherence to the MDP was associated with higher consumption of decaffeinated coffee, orange juice, other natural juices, diet carbonated drinks, low-fat milk and bottled water (P for trend ,0?001). Participants with higher adherence to the WDP were less likely to decrease their alcohol consumption during follow-up (OR between extreme quintiles 5 0?68; 95 % CI 0?56, 0?84). By contrast, participants with higher adherence to the MDP were less likely to increase their alcohol consumption (OR 5 0?66, 95 % CI 0?46, 0?95). Conclusion: In this cohort of university graduates, a healthier dietary pattern was associated with a healthier pattern of beverage consumption.

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“…As nutrients and foods are consumed in combination rather than separately, interactions are possible. For this reason, there is a recent tendency to study the overall diet, using techniques such as factor analysis to identify dietary patterns in a population (Fung et al, 2001a;Lopez-Garcia et al, 2004), or computing dietary scores, which measure the adherence to dietary guidelines (Kant et al, 2000;McCullough et al, 2000a ;Fung et al, 2001aFung et al, , 2005Trichopoulou et al, 2003;Chrysohoou et al, 2004;Pitsavos et al, 2005;Panagiotakos et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

The relationship between diet and subclinical atherosclerosis: results from the Asklepios Study

et al. 2011

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Background/Objectives: Nutritional epidemiology shifted its focus from effects of single foods/nutrients toward the overall diet. Food-based dietary guidelines (FBDGs) are promoted worldwide to stimulate a healthy diet, including a variety of foods, to meet nutrient needs and to reduce the risk for non-communicable diseases. The objective of this study was to investigate whether adherence to the FBDG is associated with reduced femoral/carotid atherosclerosis and/or inflammation. Subjects/Methods: In October 2002, 2524 healthy men and women aged 35-55 years were recruited for the Belgian Asklepios cohort study. Subjects were extensively phenotyped, including echographic assessment of (carotid and femoral) atherosclerosis. A dietary index consisting of three subscores (dietary quality, diversity and equilibrium) was calculated to measure adherence to the Flemish FBDG, using data from a semi-quantitative food-frequency questionnaire. General linear models were used to investigate associations between these scores and cardiovascular (CV) risk factors and atherosclerosis and inflammation markers. Results: Women had better overall dietary scores than men (69 vs 59%). Participants with higher dietary scores showed better age-adjusted CV risk profiles (lower waist/hip ratio, blood pressure, non-high-density lipoprotein-cholesterol, blood triglycerides and homocystein), although most of these associations were only significant in men. Higher dietary scores were also inversely associated with inflammation makers (interleukin-6 and leukocyte count). Associations between diet and atherosclerosis were only found for femoral atherosclerosis and significance disappeared after adjustment for confounders. Conclusions: Better adherence to the Flemish FBDG is associated with a better CV risk profile and less inflammation, mainly among men. There was no direct effect on the presence of carotid or femoral atherosclerosis.

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Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults

Abstract: Adherence to the traditional Mediterranean diet was associated with a reduction in the concentrations of inflammation and coagulation markers. This may partly explain the beneficial actions of this diet on the cardiovascular system.

Cited by 669 publications

References 27 publications

Adherence to the Mediterranean diet and quality of life in the SUN Project

Adherence to the Mediterranean diet and quality of life in the SUN Project

Association between dietary and beverage consumption patterns in the SUN (Seguimiento Universidad de Navarra) cohort study

The relationship between diet and subclinical atherosclerosis: results from the Asklepios Study

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