Adherence to the Mediterranean Diet and Circulating Levels of Sirtuin 4 in Obese Patients: A Novel Association

Barrea, Luigi; Tarantino, Giovanni; Somma, C. Di; Muscogiuri, Giovanna; Macchia, Paolo Emidio; Falco, Andrea; Colao, Annamaria; Savastano, Silvia

doi:10.1155/2017/6101254

Cited by 51 publications

(39 citation statements)

References 42 publications

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“…Scores of 1 and 0 were assigned for each item. The PREDIMED score was calculated as follows: score 0–5, lowest adherence; score 6–9, average adherence and score ≥10, highest adherence [26], as already reported [27,28,29,30,31].…”

Section: Methodsmentioning

confidence: 99%

Somatotropic Axis and Obesity: Is There Any Role for the Mediterranean Diet?

et al. 2019

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Obesity is associated with reduced spontaneous and stimulated growth hormone (GH) secretion and basal insulin-like growth factor I (IGF-1) levels—which in turn is associated with increased prevalence of cardiovascular risk factors. The aim of this study was to investigate: (1) the association of somatotropic axis with cardiometabolic status; (2) the association of somatotropic axis with the Mediterranean diet and nutritional pattern in people with obesity. Cross-sectional observational study was carried out in 200 adult women, aged 36.98 ± 11.10 years with severe obesity (body mass index—BMI of 45.19 ± 6.30 kg/m2). The adherence to the Mediterranean diet and the total calorie intake was assessed. Anthropometric measurements, body composition and biochemical profile were determined along with Growth Hormone (GH)/Insulin like Growth Factor 1 (IGF-1) axis and insulin resistance (homeostatic model assessment for insulin resistance—HoMA-IR). The enrolled subjects were compared after being divided according to GH peak response and according to IGF-1 standard deviation scores (SDS). Derangements of GH peak were detected in 61.5% of studied patients while IGF-1 deficiency was detected in 71% of the population. Both blunted GH peak response and IGF-1 SDS were indicators of derangements of somatotropic axis and were associated with comparable results in terms of cardiometabolic sequelae. Both GH peak and IGF-1 levels were inversely associated with anthropometric and metabolic parameters. The adherence to the Mediterranean diet predicts GH peak response. Fatty liver index (FLI), fat mass (FM) and phase angle (PhA) were predictive factors of GH peak response as well. In conclusion derangements of somatotropic axis is associated with a worse cardiometabolic profile in people with obesity. A high adherence to the Mediterranean diet—and in particular protein intake—was associated with a better GH status.

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Section: Methodsmentioning

confidence: 99%

Somatotropic Axis and Obesity: Is There Any Role for the Mediterranean Diet?

et al. 2019

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“…Considering a type I (alpha) error of 0.05 (95%), and a type II (beta) of 0.05, and the calculated power size was 95%, the minimum number of cases required for a statistical power of 95% was of 40 cases. The calculation of sample size and power were performed while using Sample Size Calculator Clinical Calc (https ://clinc alc.com/stats /sampl esize .aspx), as previously reported in other studies [24][25][26].…”

Section: Power Size Justificationmentioning

confidence: 99%

Does Sars-Cov-2 threaten our dreams? Effect of quarantine on sleep quality and body mass index

Barrea¹,

Pugliese²,

Framondi³

et al. 2020

J Transl Med

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106

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Background: COVID 19-related quarantine led to a sudden and radical lifestyle changes, in particular in eating habits. Objectives of the study were to investigate the effect of quarantine on sleep quality (SQ) and body mass index (BMI), and if change in SQ was related to working modalities. Materials: We enrolled 121 adults (age 44.9 ± 13.3 years and 35.5% males). Anthropometric parameters, working modalities and physical activity were studied. Sleep quality was evaluated by the Pittsburgh Sleep Quality Index (PSQI) questionnaire. At baseline, the enrolled subjects were assessed in outpatient clinic and after 40 days of quarantine/ lockdown by phone interview. Results: Overall, 49.6% of the subjects were good sleepers (PSQI < 5) at the baseline and significantly decreased after quarantine (p < 0.001). In detail, sleep onset latency (p < 0.001), sleep efficiency (p = 0.03), sleep disturbances (p < 0.001), and daytime dysfunction (p < 0.001) significantly worsened. There was also a significant increase in BMI values in normal weight (p = 0.023), in subjects grade I (p = 0.027) and II obesity (p = 0.020). In all cohort, physical activity was significantly decreased (p = 0.004). However, analyzing the data according gender difference, males significantly decreased physical activity as well as females in which there was only a trend without reaching statistical significance (53.5% vs 25.6%; p = 0.015 and 50.0% vs 35.9%, p = 0.106; in males and females, respectively). In addition, smart working activity resulted in a significant worsening of SQ, particularly in males (p < 0.001). Conclusions: Quarantine was associated to a worsening of SQ, particularly in males doing smart working, and to an increase in BMI values.

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“…Considering a type I (alpha) error of 0.05 (95%), and a type II (beta) of 0.05, and the calculated power size was 95%, the minimum number of cases required for a statistical power of 95% was of 40 cases. The calculation of sample size and power were performed while using Sample Size Calculator Clinical Calc (https://clincalc.com/stats/samplesize.aspx), as previously reported in other studies [24][25][26].…”

Section: Power Size Justi Cationmentioning

confidence: 99%

Does Sars-Cov-2 threaten our dreams? Effect of Quarantine on Sleep Quality and Body Mass Index

Barrea

Pugliese

Framondi

et al. 2020

Preprint

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Background: COVID 19- related quarantine led to a sudden and radical lifestyle changes, in particular in eating habits. Objectives of the study were to investigate the effect of quarantine on sleep quality (SQ) and body mass index (BMI), and if change in SQ was related to working modalities.Materials: We enrolled 121 adults (age 44.9±13.3 years and 35.5% males). Anthropometric parameters, working modalities and physical activity were studied. Sleep quality was evaluated by the Pittsburgh Sleep Quality Index (PSQI) questionnaire. At baseline, the enrolled subjects were assessed in outpatient clinic and after 40 days of quarantine/lockdown by phone interview. Results: Overall, 49.6% of the subjects were good sleepers (PSQI < 5) at the baseline and significantly decreased after quarantine (p<0.001). In detail, sleep onset latency (p<0.001), sleep efficiency (p=0.03), sleep disturbances (p<0.001), and daytime dysfunction (p<0.001) significantly worsened. There was also a significant increase in BMI values in normal weight (p=0.023), in subjects grade I (p=0.027) and II obesity (p=0.020). In all cohort, physical activity was significantly decreased (p=0.004). However, analyzing the data according gender difference, males significantly decreased physical activity as well as females in which there was only a trend without reaching statistical significance (53.5% vs 25.6%; p=0.015 and 50.0% vs 35.9%, p=0.106; in males and females, respectively). In addition, smart working activity resulted in a significant worsening of SQ, particularly in males (p<0.001). Conclusions: Quarantine was associated to a worsening of SQ, particularly in males doing smart working, and to an increase in BMI values.

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Adherence to the Mediterranean Diet and Circulating Levels of Sirtuin 4 in Obese Patients: A Novel Association

Cited by 51 publications

References 42 publications

Somatotropic Axis and Obesity: Is There Any Role for the Mediterranean Diet?

Somatotropic Axis and Obesity: Is There Any Role for the Mediterranean Diet?

Does Sars-Cov-2 threaten our dreams? Effect of quarantine on sleep quality and body mass index

Does Sars-Cov-2 threaten our dreams? Effect of Quarantine on Sleep Quality and Body Mass Index

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