Adherence to Statin Treatment and Health Outcomes in an Italian Cohort of Newly Treated Patients: Results From an Administrative Database Analysis

Adherence to statin treatment and associated factors in female users from the Unified Health System (SUS)

“…These results are in accordance with previous studies which demonstrated that patients between 50 and 65 years are more adherent to the treatment with statins (23) , and in contiguous age groups lower levels of adherence are observed within older people and, predominantly, within the younger ones (7,11) . Besides that, it was verified that men are more adherent to the treatment with statins than women (7,11) , and the non-adherence is more present in patient with less (11) or no (7) comorbidity …”

“…Insisting in the lipid-lowering treatment through statins is relevant, once it has been demonstrated that higher levels of adherence are associated with: i) lower medical costs related to the disease (25) ; ii) reduction in the risk of development of coronary arterial disease (7,10) ; and iii) decrease in the chance of hospitalization by myocardial infaction (8,25) . Within the patients who were in regular use of statin, it was verified a high adherence to treatment (71.7%), and the main factor to classify them as non-adherent was the forgetfulness to use the medication.…”

“…However, studies show the variable adherence to the treatment, with rates identified between 30 and 40% (7)(8)(9) , 50 and 70% (10) , reaching even 90% (11) . The factors influencing adherence of patients to statin treatment can be divided in three categories, known as: related to the patients (socio-economic status, comorbidities and adverse effects); to the physicians (application of guidelines recommendations and interaction with patients); and to the health system (cost and access to treatment) (12) .…”

Risk factors, prognosis, and secondary prevention of myocardial infarction in young adults in Poland

“…Degli Esposti et al [40] observed that reduced adherence was associated with younger age. Castellano et al [41] had similar findings.…”

Prevalence and reasons for non-adherence to hyperlipidemia treatment

“…In the case of hyperlipidemia, a precondition for patients to achieve benefit from treatment is taking at least 80-90% of prescribed doses of medication. Taking a lower percentage of prescribed doses leads to significant reduction in the effectiveness of treatment, increased risk of cardiovascular incidents, and mortality [7][8][9]. As observed, patients non-adherent to the statin therapy had nearly 40% greater risk of cardiovascular incident during the 3-year follow-up period, compared with the adherent ones [10].…”