Adherence to post-surgery follow-up assessment and its association with sociodemographic and disease characteristics in patients with breast cancer in Central China
Abstract:Background
Follow-up after curative surgery is increasingly recognized as an important component of breast cancer care. Although current guideline regulates the follow-ups, there are no relevant studies on the adherence to it in China. This study investigated the post-surgery follow-up and explored its association with patients, tumor and treatment characteristics.
Methods
A total of 711 patients underwent surgical treatment in Shanxi Bethune Hospital from March 2012 to May 2018 were included in this study. … Show more
“…These factors might have included poor treatment tolerance, difficulty in reaching follow-up appointments and sleep studies, or even therapy success leading to a lack of desire to follow-up further, which is often seen in a surgical context. 21 Given that the data were collected retrospectively, our study is also potentially subject to selection bias, as participant selection was from a pool of preexisting data. This may have contributed to the attrition bias.…”
Section: Discussionmentioning
confidence: 99%
“…It is also highly possible there were factors that contributed to the significant loss to follow‐up at the 1‐year time point, suggesting a potential attrition bias. These factors might have included poor treatment tolerance, difficulty in reaching follow‐up appointments and sleep studies, or even therapy success leading to a lack of desire to follow‐up further, which is often seen in a surgical context 21 . Given that the data were collected retrospectively, our study is also potentially subject to selection bias, as participant selection was from a pool of preexisting data.…”
ObjectivesThe influence of apnea‐ and hypopnea‐predominance on hypoglossal nerve stimulation therapy outcomes (HGNS) is still poorly defined. We assessed the significance of apnea‐ and hypopnea‐predominance in HGNS outcomes.Study DesignCase series with chart review.SettingSingle‐institution tertiary care center.MethodsA total of 216 subjects were included, all of which had undergone drug‐induced sleep endoscopy (DISE) and HGNS implantation. Demographic and polysomnographic data were collected. The 4% apnea‐hypopnea criteria were used to calculate apnea‐hypopnea index (AHI). Central apneas were omitted. Univariate logistic and linear regression were used to study the association between these data and apnea‐predominance and hypopnea‐predominance. Kruskal‐Wallis rank sum test was used to compare medians between groups for DISE collapse patterns.ResultsSixty‐three patients were apnea‐predominant, and 153 patients were hypopnea‐predominant. These 2 groups were similar demographically (p > .20). There was no significant difference in HGNS outcomes between the groups assessed using Sher20 criteria at the 1‐year mark using all‐night, single‐setting polysomnography or home sleep studies. Apnea index (AI)/AHI and reduction in AHI from preoperative to titration were significantly associated (p = .046). The median preoperative hypopnea index was significantly lower (p = .033) in subjects with no oropharyngeal collapse than patients with partial or complete oropharyngeal collapse. There were no significant relationships between AI/AHI and the different degrees of collapse at the velopharynx, oropharynx, tongue base, or epiglottis.ConclusionsIn line with CPAP, tonsillectomy, and mandibular advancement therapy studies, we found there was largely no significant difference in DISE anatomy or in HGNS treatment outcomes between apnea‐ and hypopnea‐predominant individuals.
“…These factors might have included poor treatment tolerance, difficulty in reaching follow-up appointments and sleep studies, or even therapy success leading to a lack of desire to follow-up further, which is often seen in a surgical context. 21 Given that the data were collected retrospectively, our study is also potentially subject to selection bias, as participant selection was from a pool of preexisting data. This may have contributed to the attrition bias.…”
Section: Discussionmentioning
confidence: 99%
“…It is also highly possible there were factors that contributed to the significant loss to follow‐up at the 1‐year time point, suggesting a potential attrition bias. These factors might have included poor treatment tolerance, difficulty in reaching follow‐up appointments and sleep studies, or even therapy success leading to a lack of desire to follow‐up further, which is often seen in a surgical context 21 . Given that the data were collected retrospectively, our study is also potentially subject to selection bias, as participant selection was from a pool of preexisting data.…”
ObjectivesThe influence of apnea‐ and hypopnea‐predominance on hypoglossal nerve stimulation therapy outcomes (HGNS) is still poorly defined. We assessed the significance of apnea‐ and hypopnea‐predominance in HGNS outcomes.Study DesignCase series with chart review.SettingSingle‐institution tertiary care center.MethodsA total of 216 subjects were included, all of which had undergone drug‐induced sleep endoscopy (DISE) and HGNS implantation. Demographic and polysomnographic data were collected. The 4% apnea‐hypopnea criteria were used to calculate apnea‐hypopnea index (AHI). Central apneas were omitted. Univariate logistic and linear regression were used to study the association between these data and apnea‐predominance and hypopnea‐predominance. Kruskal‐Wallis rank sum test was used to compare medians between groups for DISE collapse patterns.ResultsSixty‐three patients were apnea‐predominant, and 153 patients were hypopnea‐predominant. These 2 groups were similar demographically (p > .20). There was no significant difference in HGNS outcomes between the groups assessed using Sher20 criteria at the 1‐year mark using all‐night, single‐setting polysomnography or home sleep studies. Apnea index (AI)/AHI and reduction in AHI from preoperative to titration were significantly associated (p = .046). The median preoperative hypopnea index was significantly lower (p = .033) in subjects with no oropharyngeal collapse than patients with partial or complete oropharyngeal collapse. There were no significant relationships between AI/AHI and the different degrees of collapse at the velopharynx, oropharynx, tongue base, or epiglottis.ConclusionsIn line with CPAP, tonsillectomy, and mandibular advancement therapy studies, we found there was largely no significant difference in DISE anatomy or in HGNS treatment outcomes between apnea‐ and hypopnea‐predominant individuals.
“…A potential shortcoming of this study is the intake of analgesic medication when pain occurred. Finally, some follow-up assessments were incomplete for several participants, at times due to COVID−19 confinement, but in one case for unknown reasons, though likely related to lack of therapeutic adherence [ 58 ].…”
This study aimed to investigate changes in the pain sensory profile of women with breast cancer. Five women with unilateral breast cancer were enrolled. Participants were assessed with direct (quantitative sensory testing, QST) and indirect measures of pain sensitization (self-reported central sensitization inventory, CSI) at baseline (before surgery), 1 week after surgery, and at 1, 6, 9, and 12 months post-surgery. In the event of pain occurrence, the Leeds Assessment of Neuropathic Symptoms and Signs was also used. Nociceptive pain was the predominant pain mechanism in the postoperative period, while an increase in sensitization predominated one year after breast cancer surgery, especially in those participants who had received more treatment procedures. The participants who received more therapies for breast cancer experienced persistent pain and a higher level of sensitization. An assessment protocol including direct measurements (QST) and indirect measurement (self-reported CSI) allows for detecting changes in pain sensitivity, which can be useful for characterizing and/or predicting pain before, during, and up to one year following surgical interventions for breast cancer.
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