Adherence to Mediterranean diet and risk of cancer: A systematic review and meta-analysis of observational studies

Schwingshackl, Lukas; Hoffmann, Georg

doi:10.1002/ijc.28824

Cited by 238 publications

(185 citation statements)

References 65 publications

(164 reference statements)

Supporting

Mentioning

170

Contrasting

Unclassified

Order By: Relevance

“…Among other benefits, adhering to the MD has been linked to a lower risk of various chronic conditions (11,12), and its protective properties are thought to be a combination of the high intake of MUFAs and polyphenols from olive oil; PUFAs from fish; and antioxidants from fruit, vegetables, and wine (13).…”

Section: Introductionmentioning

confidence: 99%

Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence

Petersson

Philippou

2016

Advances in Nutrition

347

212

View full text Add to dashboard Cite

A growing body of evidence suggests that adherence to the Mediterranean diet (MD) may protect against cognitive decline and dementia. Many epidemiologic studies and several randomized controlled trials (RCTs) have found positive effects of the MD on cognitive function, but findings remain inconsistent. The aim of this systematic review was to provide an update on the current knowledge of the effects of the MD on cognitive function, cognitive impairment, Alzheimer disease (AD), and all-type dementia. Five databases were searched-PubMed, Embase, CINAHL, CENTRAL, and PsycINFO (1806 to 25 May 2015)-with the use of prespecified criteria. Human studies that were published in English without any restriction on study type, population assessed, intervention period, follow-up time, or publication date, and that examined the association between adherence to the MD and cognitive function or dementia symptoms (as measured by cognitive function tests), were included. Only primary publication types were included. Thirty-two studies from 25 unique cohorts, including 5 RCTs and 27 observational studies, met the inclusion criteria. The majority of studies showed that the MD was associated with improved cognitive function, a decreased risk of cognitive impairment or decreased risk of dementia, or AD. Three studies found no correlation between the MD and AD, 3 further studies found no association between the MD and cognitive impairment, and 5 studies found no association between the MD and cognitive function. There was large heterogeneity, and studies differed with regard to quality. Based on the findings and the limitations in study design, we conclude that adherence to the MD is associated with better cognitive performance. However, it should be noted that the majority of findings come from epidemiologic studies that provide evidence for a correlation between the MD and cognition but not for a cause-and-effect relation. More controlled trials are required to establish a causational relation. Adv Nutr 2016;7:889-904.

show abstract

Section: Introductionmentioning

confidence: 99%

Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence

Petersson

Philippou

2016

Advances in Nutrition

347

212

View full text Add to dashboard Cite

show abstract

“…New light on this con-troversy was shed with an extensive metaanalysis that was based on twenty-one cohort studies including 1,368,736 subjects and 12 case-control studies, with 62,725 subjects. These populations met the review objectives and were enclosed for meta-analyses (14). A high adherence to MD was associated with a signifi cant reduction in the risk of overall cancer mortality (10 %), colorectal cancer (14 %) and prostate cancer.…”

Section: And Cancermentioning

confidence: 99%

Recent data on Mediterranean diet, cardiovascular disease, cancer, diabetes and life expectancy

Ginter¹,

Simko²

2015

BLL

View full text Add to dashboard Cite

Benefi ts of dietary moderation when on a mediterranean diet type (MD) have been known for well over half a century. In the past, there has been a vigorous renewal of interest in preventive potential of MD. This review is unique, by focusing on the very recent confi rmatory data on the MD, all published within the fi rst half of 2014. Benefi ts of MD in preventing and reducing cardiovascular disorders (CVD), known before, have been strongly confi rmed. While there is little doubt regarding potential benefi t of MD for obesity, diabetes type II, metabolic syndrome and fatty liver, critical evaluation has to be aimed at reported benefi ts of MD in such widely metabolic diverse disorders as cancer, pulmonary disease and cognition defects, including Alzheimer disease (Ref. 20). Text in PDF www.elis.sk.

show abstract

“…Among other benefits, adherence to MD has been associated with a lower risk of various chronic diseases [110] [111], and its protective properties are seen as a combination of high monounsaturated fatty acid consumption and polyphenols of olive oil and polyunsaturated fatty acids of fish; and antioxidants from fruits, vegetables [112].…”

Section: Iii-2-2 Cognitive Function and Dementiamentioning

confidence: 99%

The effects of the Mediterranean Diet on Chronic Diseases: Cardiovascular Diseases, Oxidative Stress, Dyslipidemia, Diabetes Mellitus, Blood Pressure, Cancer, Neurodegenerative Disease and Obesity

Benyaich¹

2017

jaar

View full text Add to dashboard Cite

Poor dietary habits lead to the emergence of chronic diseases such as coronary heart disease, stroke, hypertension, diabetes mellitus, dyslipidemia, cancer, dementia, obesity and oxidative stress involved through the aggression of cells by free radicals, Knowing that these diseases cause a global burden both individually and economically, Several studies focus on the relationship between diet and chronic disease. Studies suggest that the Mediterranean diet, (MD) traditional eating habits and lifestyle specific to the Mediterranean region, reduce the incidence of chronic diseases and improve longevity. The MD is known to be one of the healthiest diets, this diet is based on herbs, spices, vegetables, fruits, olive oils, cereals (preferably whole grains), legumes and nuts, fish and shellfish, white meat, so the main source of dietary fat from MD is olive oil. Moderate consumption of eggs and dairy products, and reduced consumption of red meats, processed meats and foods rich in sugars and fats. MD has a beneficial fatty acid profile with a higher content of monounsaturated fatty acids (MSFA) and a higher MSFA / saturated fatty acid (SFA) ratio than non-Mediterranean diets. High consumption of dietary fiber. a low glycemic index, antiinflammatory effects, and antioxidant compounds, can work together to produce favorable effects on health status. MD is rich in vitamins and minerals, such as: vitamin B (B1, B2, niacin, B6, folate and B12) and antioxidant vitamins (vitamins E and C), and polyphenol, flavonoids, phytosterols, n-fatty acids 3 (alpha linoleic acid), resveratrol, quercetin, oleic acid, carotenoids and lutein. The purpose of this review is to provide an update on the current state of science regarding the relationship between the traditional Mediterranean diet and lifestyle related chronic diseases, and discuss the mechanisms involved and opportunities. In this area of research, to clarify and increase the confidence of the role of nutrition in the etiology of chronic diseases.

show abstract

Adherence to Mediterranean diet and risk of cancer: A systematic review and meta-analysis of observational studies

Cited by 238 publications

References 65 publications

Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence

Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence

Recent data on Mediterranean diet, cardiovascular disease, cancer, diabetes and life expectancy

The effects of the Mediterranean Diet on Chronic Diseases: Cardiovascular Diseases, Oxidative Stress, Dyslipidemia, Diabetes Mellitus, Blood Pressure, Cancer, Neurodegenerative Disease and Obesity

Contact Info

Product

Resources

About