Adherence to Mediterranean Diet and Metabolic Syndrome in <i>BRCA</i> Mutation Carriers

Bruno, Eleonora; Manoukian, Siranoush; Venturelli, Elisabetta; Oliverio, Andreina; Rovera, Francesca; Iula, Giovanna; Morelli, Daniele; Peissel, Bernard; Azzolini, Jacopo; Roveda, Eliana; Pasanisi, Patrizia

doi:10.1177/1534735417721015

Cited by 30 publications

(29 citation statements)

References 31 publications

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“…Might primary prevention options such as lifestyle changes be useful for BRCA mutation carriers? The present results and our previous findings [ 39 ] suggest that women with BRCA mutations may gain from dietary recommendations, with significant improvements in their IRm and metabolic and anthropometric parameters.…”

Section: Discussionsupporting

confidence: 83%

“…As regards the metabolic and anthropometric parameters, at baseline the two groups were fairly homogeneous. Intervention women were slightly higher ( p = 0.09) and thinner ( p = 0.20), but showed higher levels of triglycerides ( p = 0.09) and insulin ( p = 0.11), and lower levels of High Density Lipoprotein (HDL) cholesterol ( p = 0.19) [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

“…The main details of the trial have already been described [ 39 ]. Briefly, eligible study subjects were women with proved deleterious BRCA mutations, aged 18–70, with or without BC, and without metastases.…”

Section: Methodsmentioning

confidence: 99%

“…As part of a demonstration project on BRCA mutation carriers aimed at clarifying the role of lifestyle and metabolic factors in BRCA mutations penetrance, we are conducting a randomized controlled trial to test whether a dietary intervention based on the ‘Mediterranean diet’ (MedDiet) with moderate protein restriction significantly reduces IGF-I and IRm [ 21 ]. Preliminary findings from this trial indicated significantly higher adherence to the MedDiet among the women in the intervention group and suggested an inverse relation between the parameters of metabolic syndrome and adherence to the MedDiet [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

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A Dietary Intervention to Lower Serum Levels of IGF-I in BRCA Mutation Carriers

Pasanisi

Bruno

Venturelli

et al. 2018

Cancers

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Background: Insulin-like growth factor I (IGF-I) and other markers of insulin resistance (IRm) might influence the penetrance of BRCA gene mutation. In a demonstration project on BRCA mutation carriers we tested the effect of the ‘Mediterranean diet’, with moderate protein restriction, on serum levels of IGF-I and IRm. Methods: BRCA mutation carriers, with or without breast cancer, aged 18–70 years and without metastases were eligible. After the baseline examinations, women were randomized to an active dietary intervention or to a control group. The intervention group attended six full days of life-style intervention activities (cookery classes followed by lunch, sessions of walking for 45 min and nutritional conferences) over the next six months. Results: 213 BRCA mutation carriers completed the six-month study. Women in the intervention group (110) showed major changes in all the parameters under study. They significantly lost weight (p < 0.001), fat mass (p = 0.002), with reduced hip circumference (p = 0.01), triglycerides (p = 0.02) and IGF-I (p = 0.02) compared with controls. They also had a significantly higher levels of insulin-like growth factor-binding protein 3 (IGFI-BP3) (p = 0.03) and a lower IGF-I/IGFI-BP3 ratio (p = 0.04). The reduction of serum levels of IGF-I was significantly associated with the reduction in the consumption of animal products (p = 0.04). Conclusions: Women in the intervention group showed significant improvements in IGF-I and in other IRm that might influence the penetrance of BRCA mutations.

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Section: Discussionsupporting

confidence: 83%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Dietary Intervention to Lower Serum Levels of IGF-I in BRCA Mutation Carriers

Pasanisi

Bruno

Venturelli

et al. 2018

Cancers

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“…However, we found no statistically significant differences in the blood pressure and serum glucose among the high and low severity ovarian cancer. Presently, accumulating epidemiological literature has demonstrated that metabolic syndrome (MetS) is closely related to the occurrence and development of several cancers [ 19 ] . The limitations imposed by sample size can be used to explain the phenomenon.…”

Section: Discussionmentioning

confidence: 99%

Association of serum lipids and severity of epithelial ovarian cancer: an observational cohort study of 349 Chinese patients

Zhang

Liang

et al. 2018

J Biomed Res

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While obesity and fat intake have been associated with the risk and prognosis of epithelial ovarian cancer, the association between the lipid levels and epithelial ovarian cancer phenotype remains controversial. We conducted a retrospective study of 349 epithelial ovarian cancer patients who received treatment at Jiangsu Cancer Hospital, China between 2011 and 2017. We analyzed age at diagnosis, blood pressure, plasma glucose content, body mass index (BMI), lipid levels and clinical parameters. Severity of epithelial ovarian cancer was classified according to the International Federation of Gynecology and Obstetrics (FIGO) grading system. Univariate analysis of the clinical factors according to the severity of epithelial ovarian cancer was followed by logistic regression analysis to identify clinical factors significantly associated with epithelial ovarian cancer severity. Univariate analysis indicated that age, BMI, triglyceride (TG), and high density lipoproteins (HDL) differed significantly among different stages of epithelial ovarian cancer (P<0.05). In the logistic regression model, elevated TG (OR: 1.883; 95% CI= 1.207–2.937), and low HDL (OR: 0.497; 95% CI= 0.298–0.829) levels were significantly associated with the high severity epithelial ovarian cancer. Our data indicate that high TG and low HDL levels correlate with a high severity of epithelial ovarian cancer. These data provide important insight into the potential relationship between the lipid pathway and epithelial ovarian cancer phenotype and development.

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