Adherence to Capecitabine Treatment and Contributing Factors among Cancer Patients in Malaysia

Zahrina, Abdul Kadir; Norsa’adah, Bachok; Norazwany, Yaacob; Norhayati, Isa; Roslan, Mohd Haron; Nazuha, Wan Rusik Wan

doi:10.7314/apjcp.2014.15.21.9225

Cited by 16 publications

(21 citation statements)

References 24 publications

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“…Diarrhea is a specific severe side effect commonly reported by patients taking capecitabine. 4 Findings from our study confirmed the impact of the severity of diarrhea on capecitabine adherence rates, 14 although the average rate of the severity of diarrhea at 6 weeks was not high. We did find that patients who ever rated their experience with diarrhea as severe or very severe during 6 six weeks had significantly higher adherence rates.…”

Section: Effectiveness Of Self-managementsupporting

confidence: 70%

“…We found the positive direction of potential associations between adherence rates and the severity of side effects, which was in the opposite direction of what has been reported in the literature. 14 There are several possible reasons for this. For example, people who take their full dose of capecitabine may experience more side effects.…”

Section: Discussionmentioning

confidence: 99%

“…For example, Zahrina and colleagues found that patients who did not experience severe side effects of capecitabine had significantly higher adherence rates than those who experienced side effects, but they did not examine patients' ability to self-manage those side effects. 14 Spoelstra and colleagues compared a telephone-based intervention with nurse support for side effect self-management and adherence of OAAs over 8 weeks. 16 Although the intervention group reported improved severity of side effects compared to the control group, there was no significant difference in adherence between the groups.…”

Section: Introductionmentioning

confidence: 99%

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<p>Side Effects, Self-Management Activities, and Adherence to Oral Anticancer Agents</p>

Jiang¹,

Wickersham²,

Zhang³

et al. 2020

PPA

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Purpose: There are growing concerns about patients' adherence to oral anticancer agents (OAAs), and the need for patients to engage in self-management of OAA-related side effects. We assessed associations among adherence, severity of side effects, and effectiveness of self-management of side effects in patients taking capecitabine. Methods: Adherence to capecitabine at 6 weeks was measured by the Medication Event Monitoring System among 50 patients with gastrointestinal cancers. Severity of side effects related to capecitabine and effectiveness of self-management of side effects were captured using the Modified Self-Care Diary at the time of enrollment and weekly for 6 weeks. Spearman's correlation, Mann-Whitney U-tests, and multiple linear regression were conducted, p<0.05. Results: Overall mean adherence rate was 85.4±14.1%. Adherence rate was not significantly correlated to the mean severity of total side effects at any time point and was correlated with the mean effectiveness of self-management of total side effects only at week 2 (rho=0.29, p=0.04). However, adherence rate was associated with the mean severity of one specific side effect, diarrhea, at 6 weeks (rho=0.36, p=0.01) and marginally correlated to the mean effectiveness of self-management of diarrhea at 6 weeks (rho=0.28, p=0.05). Mean severity of diarrhea at 6 weeks was an independent predictor of adherence rate (b=4.97, p=0.01), with the control of age (b=0.52, p=0.002), number of outpatient medications (b=1.12, p=0.007), health literacy (b=2.53, p=0.04), diagnosis of colorectal cancer (b=11.6, p=0.03), and capecitabine in combination with other chemotherapies (b=16.8, p=0.001) in the model. Conclusion: This pilot study suggests ongoing examination of both severity and effectiveness of self-management of side effects in future studies of adherence to OAAs is merited. There is a need for future studies with larger sample sizes that explore the complex relationships among adherence, severity of side effects, and effectiveness of self-management of side effects in OAA therapy.

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Section: Effectiveness Of Self-managementsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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<p>Side Effects, Self-Management Activities, and Adherence to Oral Anticancer Agents</p>

Jiang¹,

Wickersham²,

Zhang³

et al. 2020

PPA

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“…Cancer patients are often thought to be highly motivated by the gravity of their disease, with “too much to lose” by being nonadherent (Ziller et al 2009 ; Waterhouse et al 1993 ; Zahrina et al 2014 ; Winterhalder et al 2011 ). Recent studies reported adherence rates between 82.6 and 96.8 % in patients suffering from metastatic disease (Figueiredo Junior and Forones 2014 ; Smith et al 2015 ; Timmers et al 2015 ).…”

Section: Discussionmentioning

confidence: 99%

“…Despite a substantial number of studies in the past decades (DiMatteo 2004 ; Vermeire et al 2001 ) there is still no “gold-standard” method (Foulon et al 2011 ; Grymonpre et al 2006 ; Vermeire et al 2001 ; Banning 2008 , 2012 ; Waterhouse et al 1993 ; Escalada and Griffiths 2006 ) in measuring adherence and only a combination of measures can maximize accuracy (Osterberg and Blaschke 2005 ; Wang et al 2004 ; Zahrina et al 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Adherence assessment of patients with metastatic solid tumors who are treated in an oncology group practice

et al. 2016

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Due to the increase of oral agents nonadherence is an emerging challenge in cancer care. We evaluated how well different assessments match and how adherence could be measured in routine care. For this purpose patients suffering from metastatic solid tumors who were treated with oral anticancer drugs in an oncology group practice were surveyed. Attending oncologists answered a questionnaire, too, and a retrospective analysis of prescription data was conducted. Caregivers who were eligible for an interview were surveyed additionally. 128 patients (70 % female) with a median age of 69 years (36–88) took part, 95 % of all approached patients. 56 % suffered from metastatic breast cancer, 44 % from other metastatic solid tumors. 65 caregivers (60 % female) with a median age of 62 years (21–82) were interviewed as well. Patients were assessed in 84 % as very reliable in medication-taking by their oncologists. This high adherence rate was supported by patients, caregivers and prescription data. However, concordance between assessments of patients, caregivers and oncologists was not substantial. Our method of considering different perspectives to assess adherence has to be improved and validated but could help to evaluate adherence with oral cancer therapy in routine care.

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High adherence of patients with multiple myeloma who receive treatment with immunomodulatory drugs (IMIDS) in hematology/oncology group practices in Germany

Feiten

Chakupurakal

Feustel

et al. 2019

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Adherence to Capecitabine Treatment and Contributing Factors among Cancer Patients in Malaysia

Cited by 16 publications

References 24 publications

<p>Side Effects, Self-Management Activities, and Adherence to Oral Anticancer Agents</p>

<p>Side Effects, Self-Management Activities, and Adherence to Oral Anticancer Agents</p>

Adherence assessment of patients with metastatic solid tumors who are treated in an oncology group practice

High adherence of patients with multiple myeloma who receive treatment with immunomodulatory drugs (IMIDS) in hematology/oncology group practices in Germany

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