Adherence to antiepileptic drugs for epileptic patients attending neurology outpatient department in tertiary care center - A prospective observational study

T, Dhivya Devi; Shanthi, M.; J, Ezhil Ramya

doi:10.5455/njppp.2021.11.08227202001122020

Cited by 1 publication

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“…Adverse effects of AEDs are major causes of iatrogenic disease and make a significant contributionto reduced quality of life in individuals with epilepsy. Overall, the incidence of patients experienced ADR in this study was found to be 110(34.37%) which was in line with the finding reported from Malaysia (31%) [ 30 ], India (30%) [ 26 ], and Ethiopia (37%) [ 24 ]. This showed that adverse effects associated with AED were common among epileptic patients.…”

Section: Discussionsupporting

confidence: 91%

“…In the current study, the frequently identified DTP was noncompliance 115(36%) with the main reasons of forgetfulness followed by the expensiveness of the drug products. This finding was comparable with the other study done in Ethiopia (34.1%) [ 24 ], Saud Arabia (38%) [ 25 ], India (37%) [ 26 ], and China (33.3%) [ 27 ]. However, it was higher than the study conducted in Paris [ 28 ] and USA [ 29 ] where 21% and 26% of study participants were noncompliant to AEDs respectively.…”

Section: Discussionsupporting

confidence: 90%

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Drug therapy problems and predicting factors among ambulatory epileptic patients in Jimma Medical Center, Southwest Ethiopia

Babu¹,

Daba

Goro

et al. 2022

PLoS ONE

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BackgroundThe care of epileptic patients is complicated by the cognitive adverse effect of the drug, disease, pharmacokinetics, and pharmacodynamics properties of antiepileptic drugs which in turn intensify the risk of drug therapy problems among epileptic patients.ObjectiveTo assess drug therapy problems and predicting factors among ambulatory epileptic patients at Jimma University Medical Center, Southwest Ethiopia, from September 2020 to May 2021.MethodologyA hospital-based prospective observational study was conducted. A semi-structured questionnaire was used to collect data from patients as well as from charts. Drug therapy problems were identified using Cipolle’s, Morley, and Strand drug therapy problem identification and classification method. Data were entered into Epi data manager version 4.6 and exported to statistical software package for social science version 23.0 for analysis. Multiplestepwise backward logistic regression analysis was carried out to identify predictors of drug therapy problems. The 95% CI was used to show an association between the dependent and independent variables. P-value < 0.05 was considered as statistically significant.ResultsOf the total 320 epileptic patients 224(70.0%) patients had at least one drug therapy problem. A total of 395 drug therapy problems were identified among two hundred twenty-four patients with an average of 1.2 drug therapy problems per patient. The frequently identified drug therapy problems were non-compliance 115(29.11), adverse drug reaction 110(27.84%), and dose too low 103(26%). Getting of a drug by purchasing [AOR = 4.6,95%CI:(2.05–10.7)], poorly involvement of the patients in therapeutic decision making [AOR = 3.02,95%CI:(1.5–6.06)], the number of medications ≥ two [AOR = 5.3,95%CI:(1.2–22.9)] and having had uncontrolled seizure [AOR = 10.9,95%CI:(4.9–24.2)] were independent predictors of drug therapy problems.ConclusionsDrug therapy problems were common among epileptic patients in the study area. Patients who were getting their drugs by purchasing, poorly involved in therapeutic decision making, having had an uncontrolled seizure, and taking two and above drugs were more likely to experience drug therapy problems. Therefore, due attention should be given to patients with the aforementioned problems to decrease the occurrence of drug therapy problems and improve overall outcomes among epileptic patients.

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Section: Discussionsupporting

confidence: 91%