Adherence to Antidepressant Treatment Among Privately Insured Patients Diagnosed With Depression

Akincigil, Ayşe; Bowblis, John R.; Levin, Carrie A.; Walkup, James; Jan, Saira; Crystal, Stephen

doi:10.1097/01.mlr.0000254574.23418.f6

Cited by 136 publications

(130 citation statements)

References 36 publications

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“…In one study reported that adherent subjects had a higher level of satisfaction with their physicians, with 87% indicating "excellent" or "very good," while only 60% of the nonadherent subjects indicated this level of satisfaction [21,22]. Unawareness of nature of depression disorder and adherence to treatment regimen has significantly influenced (p=0.49, t-test) mean drug attitude inventory scores in our study.…”

Section: Discussionmentioning

confidence: 58%

Treatment and Disease Related Factors Affecting Non-adherence among Patients on Long Term Therapy of Antidepressants

M¹

2015

J Depress Anxiety

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Introduction: Depression is a term used to describe a health problem in which mood pattern will be affected. Clinical depression is more severe and the symptoms can continue for weeks, months, and even years in some cases if it is not treated and it does interfere with our ability to function and it also can leads to suicide at its worst. Although clinical guidelines recommend antidepressants be continued for at least 6 months after symptom remission, approximately one third of patients discontinue antidepressants within the first month of treatment, and 44% discontinue them by the third month of treatment. Adherence to antidepressants is a stimulating problem in the management of patients with depression. Various factors such as nature and duration of therapy, disease characteristics, medication side-effects, cost of treatment, characteristics of health service facilities, the relation among the physician and patient, patient characteristics such as socioeconomic factors, patient's perspective about the illness and treatment have been reported to influence adherence.

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Section: Discussionmentioning

confidence: 58%

Treatment and Disease Related Factors Affecting Non-adherence among Patients on Long Term Therapy of Antidepressants

M¹

2015

J Depress Anxiety

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“…[38] Younger patients have a stronger negative bias towards issues such as weight gain, sexual dysfunction and dissatisfaction with the physician. [39,40] We also demonstrated that the treatment period has a definite influence on the MPR and patient compliance. We found that patients were prescribed an oversupply of AD during the first month of treatment.…”

Section: Discussionmentioning

confidence: 95%

Prospective analysis of the medicine possession ratio of antidepressants in the private health sector of South Africa, 2006 - 2011

et al. 2015

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Background. Major depressive disorder (MDD) is a disabling mental illness with high morbidity and mortality rates. Inadequate treatment efficacy, unfavourable side-effect profiles and consequent shortfalls in compliance are major stumbling blocks in its treatment. Noncompliance data in low-to middle-income countries are lacking. Objective. To investigate the prevalence of antidepressant (AD) non-compliance in the private healthcare sector of South Africa (SA). Methods. We conducted a prospective cohort study analysing AD medicine claims (N=35 175) for 14 135 patients, obtained from a nationally representative pharmaceutical benefit management company, over a 6-year study period (1 January 2006 -31 December 2011). The medicine possession ratio (MPR) was used as a proxy to determine compliance with AD medication. Only patients >18 years of age whose treatment had been initiated by a psychiatrist following an appropriate International Classification of Diseases (10th edition) (ICD-10) diagnosis of a mood disorder were included. A patient was considered compliant if the MPR was between ≥80% and ≤110% over a >4-month treatment period. Results. After the first 4 months, only 34% of patients were compliant. A statistically significant association was found between active ingredient consumed and compliance (p<0.0001). Only 26.2% of patients who received amitriptyline-containing products were compliant, compared with 38.8% and 38.7% for venlafaxine and duloxetine, respectively. Conclusion. Compliance data collected from pharmacy claims provide a workable estimate of the broader clinical scenario they represent. Although differences between classes of AD were evident, non-compliance was found to be high in the private healthcare environment of SA, comparable with global trends.

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“…Other studies have found mixed effects for the impact of disease burden on medication adherence, with some finding improved adherence in patients with greater comorbidity, 36,37 and others finding no effect or decreased adherence. 33,[38][39][40] There was a strong association between provider type and early adherence to antidepressants. Patients who received their antidepressants from psychiatrists were more likely to refill their antidepressants than those treated in primary care.…”

Section: Discussionmentioning

confidence: 99%

Antidepressant Adherence Across Diverse Populations and Health Care Settings

Rossom¹,

Shortreed²,

Coleman³

et al. 2016

Journal of Patient-Centered Research and Reviews

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Adherence to Antidepressant Treatment Among Privately Insured Patients Diagnosed With Depression

Abstract: Background-Antidepressants are effective in treatment of depression, but poor adherence to medication is a major obstacle to effective care.

Cited by 136 publications

References 36 publications

Treatment and Disease Related Factors Affecting Non-adherence among Patients on Long Term Therapy of Antidepressants

Treatment and Disease Related Factors Affecting Non-adherence among Patients on Long Term Therapy of Antidepressants

Prospective analysis of the medicine possession ratio of antidepressants in the private health sector of South Africa, 2006 - 2011

Antidepressant Adherence Across Diverse Populations and Health Care Settings

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