Adherence to Anti-tuberculosis treatment and treatment outcomes among tuberculosis patients in Alamata District, northeast Ethiopia

Tesfahuneygn, Gebrehiwet; Medhin, Girmay; Legesse, Mengistu

doi:10.1186/s13104-015-1452-x

Cited by 115 publications

(179 citation statements)

References 26 publications

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“…Similar findings were reported from previous studies in Ethiopia [13] [15] [31]. Evidence also indicates that less proportion of EPTB cases compared to other forms of TB were observed in other studies conducted in Ethiopia [14] [16].…”

Section: Discussionsupporting

confidence: 90%

“…In our study, despite the high treatment success rate of new PTB+ ve cases, the overall cure rate was 72.1%, which is lower than previous cure rate reports of 85.5% from Northern Ethiopia [12] and 81.1% in North West Ethiopia [31]. Sputum smear examination at two, five and seven months is recommended as part of anti-TB treatment follow up.…”

Section: Discussioncontrasting

confidence: 73%

“…In this study, the overall treatment success rate for all TB patients was 94.4% and is higher than the 90% global target as set by WHO [29]. The study result is also higher compared to previous treatment success rate reports of 87.8% and 85.6% in North West Ethiopia [15] [30], 55.7% in Western Ethiopia [14], 82.7% in Addis Ababa [13], and 91.1% in Northern Ethiopia [31]. Another study from North West Ethiopia showed a treatment success rate of 94.8% which is comparable with our study result [32].…”

Section: Discussioncontrasting

confidence: 60%

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Tuberculosis Case Notification and Treatment Outcomes in West Gojjam Zone, Northwest Ethiopia: A Five-Year Retrospective Study

Gebreegziabher¹,

Yimer²,

Bjune³

2016

JTR

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Introduction: Tuberculosis (TB) is a major public health concern in Ethiopia. Analysis of TB case notification and treatment outcomes is crucial to understand the TB control program performance. The current study was carried out to assess trends of TB case notifications, treatment success rate and factors associated with unsuccessful treatment outcome among TB patients in West Gojjam Zone of Amhara Region, Ethiopia. Method: A retrospective cohort study was conducted in West Gojjam Zone. Demographic and clinical data were reviewed for all TB patients registered between July 2007 and June 2012 at 30 randomly selected public health facilities of the study zone. In addition, annual case notification reports of the study zone were used to analyze trends in TB case notifications. Logistic regression analysis was used to assess the association between potential predictor variables and unsuccessful treatment outcomes. Results: Tuberculosis case notification for all forms of TB decreased from 203/100,000 population in 2007 to 155/100,000 population in 2012. Among patients whose treatment outcomes were evaluated, 94.4% were successfully treated, 0.3% had treatment failure, 1.5% defaulted and 3.7% died. In multivariate analysis, the odds of unsuccessful treatment outcome was higher among retreatment cases than new cases (adjusted OR, 3.44; 95% CI: 1.92, 6.19). HIV co-infected cases were more likely to have unsuccessful treatment outcome compared to HIV negatives (adjusted OR, 2.68; 95% CI: 1.92, 3.72). Conclusion: Tuberculosis case notification rates showed a decreasing trend between 2007 and 2012. The * Corresponding author. S. B. Gebreegziabher et al. 24treatment success rate exceeded the 90% treatment success rate target as set by the WHO. Special attention is required for patients with high risk of unsuccessful treatment outcome. Therefore, retreatment cases, and HIV positive cases need strict follow up throughout their treatment period.

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Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 73%

Section: Discussioncontrasting

confidence: 60%

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Tuberculosis Case Notification and Treatment Outcomes in West Gojjam Zone, Northwest Ethiopia: A Five-Year Retrospective Study

Gebreegziabher¹,

Yimer²,

Bjune³

2016

JTR

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“…Cases on retreatment were twice as likely to default treatment relative to their newly diagnosed counterparts. Studies in Morocco 13,41,42 [ 8 _ T D $ D I F F ] and Ethiopia, 43 and in the Eastern Cape, KwaZulu-Natal, and Eastern Cape Provinces of South Africa 44 have reported similar findings. In the South African study, self-reported reasons for defaulting included self-perceived improved health, and structural and psychosocial problems.…”

Section: Discussionmentioning

confidence: 68%

Factors influencing treatment default among tuberculosis patients in a high burden province of South Africa

Kigozi

Heunis

Chikobvu

et al. 2017

International Journal of Infectious Diseases

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“…There was a high level of adherence to anti-TB treatment and also a high TB treatment success rate. 4 Countries implementing DOT to ensure treatment adherence have shown impressive results with increasing treatment success and low default rates. 1,5,6 India has had an ongoing National TB Program (NTP) since 1962.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Success Rate of Directly Observed Treatment Short-Course (DOTS) in Tuberculosis Patients of South India

Prudhivi¹,

Challa²,

Mv³

et al. 2018

JYP

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Objective: To assess the success rate of DOTS for tuberculosis patients and the secondary objective was to identify the factors associated with unsuccessful treatment outcome. Methods: A retrospective study was conducted to review the medical records of patients (n = 1113) registered at the Directly Observed Treatment Short-Course (DOTS) clinic of Government Infectious Disease (Govt. ID) Hospital, Guntur, India. Multivariate logistic regression model was used to determine the factors associated with the treatment success rate. Results: The overall mean success rate of TB patients was found to be 82.8%. Treatment success rate (TSR) was steadily increased across the years from 73.9% in 2015 to 84.3% in 2016 and 88.9% in 2017 while the death rate was steadily decreased from 11.2% in 2015 to 6.25% in 2016 and 4.33% in 2017. Risk factors significantly associated with unsuccessful treatment outcome were found to be HIV positive (P<0.001), smear negative (P<0.001), all retreatment cases (P<0.001), smoking (P=0.008), and alcoholism (P=0.019). Smear positive patients had lower death rate (3.9% vs. 10.1%; P < 0.001) and failure rate ((2.6% vs. 8.7%; P < 0.001) compared to smear negative patients. Patients tested HIV positive had seen significantly unfavorable outcomes in death rate (OR= 9.17,; P < 0.001) and treatment failure (OR=13.3, 95% CI= 7.31-24.17; P < 0.001). Conclusion: Implementing the DOTS strategy proved the satisfactory success rate in the South Indian hospital across three years. The unsuccessful treatment outcome was significantly associated with gender, HIV status, re-treatment, smear negative, smoking and alcoholism.This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Adherence to Anti-tuberculosis treatment and treatment outcomes among tuberculosis patients in Alamata District, northeast Ethiopia

Cited by 115 publications

References 26 publications

Tuberculosis Case Notification and Treatment Outcomes in West Gojjam Zone, Northwest Ethiopia: A Five-Year Retrospective Study

Tuberculosis Case Notification and Treatment Outcomes in West Gojjam Zone, Northwest Ethiopia: A Five-Year Retrospective Study

Factors influencing treatment default among tuberculosis patients in a high burden province of South Africa

Assessment of Success Rate of Directly Observed Treatment Short-Course (DOTS) in Tuberculosis Patients of South India

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