Adherence to anti-inflammatory treatment for asthma in clinical practice in France

Latry, Philippe; Pinet, Marion; Labat, Anne; Magand, Jean-Pierre; Peter, Claude; Robinson, Philip; Martin-Latry, Karin; Molimard, Mathiéu

doi:10.1016/j.clinthera.2008.06.011

Cited by 50 publications

(31 citation statements)

References 35 publications

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“…According to a study by Singh et al, longer disease durations may motivate patients to search for complementary therapies as “magic cures,” due to the perception that the lack of improvement in their asthma symptoms is due to the ineffectiveness of their current treatment 37. To the contrary, Latty et al studied adherence to asthma inhalers and leukotriene receptor antagonists and found that 12-month persistence rates were lower in new medications users (1.5%–6%) than in chronic medication users (27%–44%) 38. This suggests that perhaps, after years of suffering from asthma, patients may be more likely to accept and follow prescribed treatment regimens 36…”

Section: Discussionmentioning

confidence: 99%

“…Medication persistence was measured using the CMG, which quantifies the gaps between prescription refills over multiple refill intervals, calculated as follows:16…”

Section: Methodsmentioning

confidence: 99%

“…Computation of the CMG takes oversupply into account, therefore, the resulting value cannot exceed 1 16. The MPR and CMG are both indirect measures that indicate overall patient adherence.…”

Section: Methodsmentioning

confidence: 99%

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Adherence to preventive medications in asthmatic children at a tertiary care teaching hospital in Malaysia

Redzuan¹,

Lee²,

Shah³

2014

PPA

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PurposeAsthma affects an estimated 300 million people worldwide. Poor adherence to prescribed preventive medications, especially among children with asthma, leads to increased mortality and morbidity. The purpose of this study was to assess the adherence and persistence levels of asthmatic children at the Universiti Kebangsaan Malaysia Medical Center (UKMMC), a tertiary care teaching hospital, and to determine the factors that influence adherence to prescribed preventive medications.Patients and methodsParticipants were asthmatic patients aged 18 years and younger with at least one prescription for a preventive medication refilled between January and December 2011. Refill records from the pharmacy dispensing database were used to determine the medication possession ratio (MPR) and continuous measure of gaps (CMG), measures of adherence and persistence levels, respectively.ResultsThe sample consisted of 218 children with asthma from the General and Respiratory pediatric clinics at UKMMC. The overall adherence level was 38% (n=83; MPR ≥80%), and the persistence level was 27.5% (n=60; CMG ≤20%). We found a significant association between the adherence and persistence levels (r=0.483, P<0.01). The presence of comorbidities significantly predicted the adherence (odds ratio [OR] =16.21, 95% confidence interval [CI]: 7.76–33.84, P<0.01) and persistence level (OR =2.63, 95% CI: 0.13–52.79, P<0.01). Other factors, including age, sex, ethnicity, duration of asthma diagnosis, and number of prescribed preventive medications did not significantly affect adherence or persistence (P>0.05).ConclusionIn conclusion, the adherence level among children with asthma at UKMMC was low. The presence of comorbidities was found to influence adherence towards preventive medications in asthmatic children.

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Section: Discussionmentioning

confidence: 99%

“…Medication persistence was measured using the CMG, which quantifies the gaps between prescription refills over multiple refill intervals, calculated as follows:16…”

Section: Methodsmentioning

confidence: 99%

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Adherence to preventive medications in asthmatic children at a tertiary care teaching hospital in Malaysia

Redzuan¹,

Lee²,

Shah³

2014

PPA

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“…This should suggest that either the therapy taken over the previous 5 years was ineffective or that a low level of treatment had been prescribed (see patients 3 and 4 described in Figure 1a and 1b respectively and patients in Figure 1c). Drugs might also have been taken partially or not at all (poor adherence) (see patients in Figure 1d) and this may affect 27-57% of asthmatics [84][85][86][87] . In addition, subjects may have had problems in using the device correctly [88][89][90] .…”

Section: And Fvcmentioning

confidence: 99%

Could FEV₁decline have a role in daily clinical practice for asthma monitoring?

Sposato¹

2013

Current Medical Research and Opinion

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“…A plethora of studies have reported about poor adherence to asthma medication treatment [1-4]. As an example, an overall adherence to asthma medication of 22% in a sample of 5,500 persons with asthma was reported in one study [5].…”

Section: Introductionmentioning

confidence: 99%

Recent educational interventions for improvement of asthma medication adherence

Axelsson

Lötvall

2012

Asia Pacific Allergy

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Poor adherence to asthma medication treatment is a dilemma as it decreases the chance of achieving and maintaining a proper asthma control. Another dilemma is that there seems to be a small range of functional interventions that enhance adherence to long-term medication treatments. The aim was to review the last five years of published educational interventions for improving adherence to asthma medication. Through systematic database searches 20 articles were identified, which matched the inclusion criteria and described educational interventions to improve asthma self-management including adherence. The current review showed that addressing unintentional non-adherence in terms of incorrect inhaler technique by recurrent education improved the technique among many patients, but not among all. Phoning patients, as a means to remove medication beliefs as adherence barriers, seemed to be an effective educational strategy, shown as increased adherence. Involving patients in treatment decisions and individualising or tailoring educational support also seemed to have favourable effect on adherence. To conclude, addressing specific adherence barriers such as poor inhaler technique or medication beliefs could favour adherence. To change adherence behavior, the current review proposes that educational adherence support should be a collaborative effort between the patient and the health-care professional based on each individual patient's needs and patient factors, including elements such as personality traits.

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Adherence to anti-inflammatory treatment for asthma in clinical practice in France

Cited by 50 publications

References 35 publications

Adherence to preventive medications in asthmatic children at a tertiary care teaching hospital in Malaysia

Adherence to preventive medications in asthmatic children at a tertiary care teaching hospital in Malaysia

Could FEV₁decline have a role in daily clinical practice for asthma monitoring?

Recent educational interventions for improvement of asthma medication adherence

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Adherence to anti-inflammatory treatment for asthma in clinical practice in France

Cited by 50 publications

References 35 publications

Adherence to preventive medications in asthmatic children at a tertiary care teaching hospital in Malaysia

Adherence to preventive medications in asthmatic children at a tertiary care teaching hospital in Malaysia

Could FEV1decline have a role in daily clinical practice for asthma monitoring?

Recent educational interventions for improvement of asthma medication adherence

Contact Info

Product

Resources

About

Could FEV₁decline have a role in daily clinical practice for asthma monitoring?