Adherence to abiraterone or enzalutamide in elderly metastatic castration-resistant prostate cancer

Banna, Giuseppe Luigi; Urzia, Valeria; Benanti, Chiara; Pitrè, Alessandra; Lipari, Helga; Quattro, R. Di; Giorgi, Ugo De; Schepisi, Giuseppe; Basso, Umberto; Bimbatti, Davide; Rundo, Francesco; Libra, Massimo; Malatino, Lorenzo

doi:10.1007/s00520-020-05311-5

Cited by 19 publications

(51 citation statements)

References 26 publications

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“…In addition, CPT-11 is also used to treat esophageal cancer, cervical cancer, leukemia, etc. The toxic and side effects during treatment are mainly intestinal reactions, adverse reactions of the blood system, and complex symptoms such as hair loss, fatigue, mucositis, and skin toxicity (including hand-foot syndrome) [ 20 ]. Existing studies believe that, from the perspective of drug metabolism, this is mainly due to the toxicity of the central metabolite of CPT-11.…”

Section: Concepts Related To the Management Effect Of Cancer Patients...mentioning

confidence: 99%

Analysis of the Management Effect of Cancer Patients after Oral Chemotherapy Based on Nursing Process Reengineering

Chen

Zhang

Li³

2022

Journal of Healthcare Engineering

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With the pollution of the environment and the acceleration of the social rhythm, the prevalence of tumors has increased year by year, and tumors have brought huge pain and inconvenience to patients. However, traditional nursing work consumes a lot of manpower and material resources, but it is difficult to improve the happiness of cancer patients, and it also brings a lot of troubles to many nursing workers. Based on the above reasons, we reengineered the traditional nursing process based on the BPR theory and applied the new process to the analysis of the management effect of cancer patients after oral chemotherapy drugs. The data shows that there are 23 patients with no pressure ulcer risk (score greater than 19) before care, 27 patients with low risk (15–19 points), 32 patients with moderate risk (13–14 points), and 18 people at high risk (less than 12 points). After nursing, there were 82 patients with no pressure ulcer risk, 10 patients with low risk, 7 patients with moderate risk, and 1 patient with high risk. This shows that the risk of pressure ulcers in patients with cancer after the use of chemotherapy drugs is significantly reduced compared with those without nursing. Nursing intervention can improve the psychological state of cancer patients during the recovery period, and nursing intervention can promote the compliance of cancer patients in various aspects of rehabilitation.

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Section: Concepts Related To the Management Effect Of Cancer Patients...mentioning

confidence: 99%

Analysis of the Management Effect of Cancer Patients after Oral Chemotherapy Based on Nursing Process Reengineering

Chen

Zhang

Li³

2022

Journal of Healthcare Engineering

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“…Twelve studies (31%) out of 42 did not find any statistically significant correlation between adherence levels and clinical outcome. [14][15][16][17][18][19][20][21][22][23][24][25] In two studies (5%) a correlation was found for only one of the outcomes considered (quality of life and EFS) while no correlation was found for the other outcomes (respectively major molecular response and PFS and OS). 26,27 In five studies (9%), the authors reported that there was a correlation between outcome and adherence, but that it was not statistically significant.…”

Section: Calculation Methods and Correlationsmentioning

confidence: 99%

“…14 In one study, non-adherence was estimated according to missed doses reported by the patient along with the reasons for not taking the prescribed doses without specifying cut-offs. 15…”

Section: Medication Adherencementioning

confidence: 99%

“…Oncology = 14 (15,25,21,22,23,24,27,42,43,44,48,49,52,69) Haematological = 28 (14,16,17,18,32,19,20,26,28,29,30,31,33,34,35,36,37,38,8,39,40,41,46,47,48,9,67,68) Methods used in calculating adherence: Laboratory assessment = 14 (14,16,18,20,33,34,35,36,37,8,…”

Section: Scopementioning

confidence: 99%

“…The most prominent endpoint in the evaluation of treatments for solid tumours is OS, which was considered in six 15,23,24,44,48,52 out of 14 studies, of which three 44,48,52 established a significant correlation with treatment adherence.…”

Section: Outcomementioning

confidence: 99%

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Association between adherence to oral therapies in cancer patients and clinical outcome: A systematic review of the literature

Lasala

Santoleri

2021

Brit J Clinical Pharma

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which considered the use of oral anticancer drugs for cancer patients and which correlated treatment adherence with a clinical outcome, were considered. Results:From the 42 studies considered in the systematic review, 14 were for oncological indications and 28 for haematological indications. There was considerable variance in calculation methods, outcomes considered, and in the definitions of adherence. However, it emerged that most studies reported a significant correlation between adherence to therapy and clinical outcome. Conclusion:As adherence to therapy is a key factor in achieving a better clinical outcome, future studies with large samples, robust endpoints and the use of at least two methods of assessing adherence would be desirable in order to produce more robust evidence.

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Next-Generation Androgen Receptor-Signaling Inhibitors for Prostate Cancer: Considerations for Older Patients

Feng

Graff

2021

Drugs Aging

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Adherence to abiraterone or enzalutamide in elderly metastatic castration-resistant prostate cancer

Cited by 19 publications

References 26 publications

Analysis of the Management Effect of Cancer Patients after Oral Chemotherapy Based on Nursing Process Reengineering

Analysis of the Management Effect of Cancer Patients after Oral Chemotherapy Based on Nursing Process Reengineering

Association between adherence to oral therapies in cancer patients and clinical outcome: A systematic review of the literature

Next-Generation Androgen Receptor-Signaling Inhibitors for Prostate Cancer: Considerations for Older Patients

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