Adherence to a Mediterranean diet, genetic susceptibility, and progression to advanced macular degeneration: a prospective cohort study

Merle, Bénédicte M. J.; Silver, Rachel E; Rosner, Bernard; Seddon, Johanna M.

doi:10.3945/ajcn.115.111047

Cited by 106 publications

(136 citation statements)

References 54 publications

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“…Some researchers criticize AREDS2 stating that the design, setting, and selection of patients of AREDS2 trial had not allowed ascertaining the potential of omega-3 supplements [85] due to an inadequate duration of treatment, inadequate dose, or both [56, 85]. Another possible explanation is that the effect may be modified by underlying genetic risk factors [86, 87]. It is also possible that there is an optimal level of supplementation with omega-3 fatty acids and if the level is not optimal it could be ineffective or detrimental.…”

Section: Omega-3 Supplementationmentioning

confidence: 99%

“…Association of a particular nutrient to AMD is difficult and impossible to dissociate from other aspects of the diet. More importantly, there are synergistic relationships of the food components [3, 26, 86]. …”

Section: Mediterranean Diet and Amdmentioning

confidence: 99%

“…In the Carotenoids Age-Related Eye Disease Study (CAREDS), the high adherence to a Mediterranean diet was associated with a lower prevalence of early AMD [86]. Previously, it was reported that advanced AMD was related to overall diet quality using the Health Eating Index (HEI) [102].…”

Section: Mediterranean Diet and Amdmentioning

confidence: 99%

“…Merle and collaborators used the data from 2525 individuals of the AREDS trial and dietary information collected from food-frequency questionnaires and the alternate Mediterranean diet score [86]. This score was constructed from individual intake of vegetables, fruit, legumes, whole grain, nuts, fish, red and processed meats, alcohol, and the ratio of monounsaturated to saturated fats.…”

Section: Mediterranean Diet and Amdmentioning

confidence: 99%

“…They reported that a high score was associated with a 26% reduced risk of progression to advanced AMD after adjustments for demographic, behavioral, ocular, and genetic factors. The consumption of fish and vegetables was associated with a lower risk of progression to advanced AMD [86]. The administration of AREDS supplements did not change the protective effect of the Mediterranean diet on the risk of progression [86].…”

Section: Mediterranean Diet and Amdmentioning

confidence: 99%

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Nutritional and Lifestyle Interventions for Age‐Related Macular Degeneration: A Review

Carneiro

Andrade

2017

Oxidative Medicine and Cellular Longevity

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Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world. In this narrative review, we will summarize the nutritional interventions evaluated in numerous observational studies and a few randomized clinical trials. The AREDS and AREDS2 studies demonstrated that supplements including vitamins C and E, beta-carotene, and zinc may reduce the progression to advanced AMD, in some patients, by 25% in five years. This is one of the few nutritional supplements known to have beneficial effects in any eye disease. Lutein/zeaxanthin supplementation may have beneficial effects in some individuals whereas omega-3 fatty acids supplementation needs to be further investigated and supported by more evidence. Genetic factors may explain the different patterns of response and explain differences found among individuals. More importantly, a combination of lifestyle behaviors such as the avoidance of smoking, physical activity, and the adoption of a healthy dietary pattern like the Mediterranean diet was associated with a lower prevalence of AMD. The adoption of these lifestyles may reduce the prevalence of the early stages of AMD and decrease the number of individuals who develop advanced AMD and consequently the onerous and climbing costs associated with the treatment of this disease.

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Section: Omega-3 Supplementationmentioning

confidence: 99%

Section: Mediterranean Diet and Amdmentioning

confidence: 99%

Section: Mediterranean Diet and Amdmentioning

confidence: 99%

Section: Mediterranean Diet and Amdmentioning

confidence: 99%

Section: Mediterranean Diet and Amdmentioning

confidence: 99%

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Nutritional and Lifestyle Interventions for Age‐Related Macular Degeneration: A Review

Carneiro

Andrade

2017

Oxidative Medicine and Cellular Longevity

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Oxidative Stress and Dysfunctional Intracellular Traffic Linked to an Unhealthy Diet Results in Impaired Cargo Transport in the Retinal Pigment Epithelium (RPE)

Keeling

Chatelet

Johnston

et al. 2019

Molecular Nutrition Food Res

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Scope Oxidative stress and dysregulated intracellular trafficking are associated with an unhealthy diet which underlies pathology. Here, these effects on photoreceptor outer segment (POS) trafficking in the retinal pigment epithelium (RPE), a major pathway of disease underlying irreversible sight‐loss, are studied. Methods and results POS trafficking is studied in ARPE‐19 cells using an algorithm‐based quantification of confocal‐immunofluorescence data supported by ultrastructural studies. It is shown that although POS are tightly regulated and trafficked via Rab5, Rab7 vesicles, LAMP1/2 lysosomes and LC3b‐autophagosomes, there is also a considerable degree of variation and flexibility in this process. Treatment with H2O2 and bafilomycin A1 reveals that oxidative stress and dysregulated autophagy target intracellular compartments and trafficking in strikingly different ways. These effects appear limited to POS‐containing vesicles, suggesting a cargo‐specific effect. Conclusion The findings offer insights into how RPE cells cope with stress, and how mechanisms influencing POS transport/degradation can have different outcomes in the senescent retina. These shed new light on cellular processes underlying retinopathies such as age‐related macular degeneration. The discoveries reveal how diet and nutrition can cause fundamental alterations at a cellular level, thus contributing to a better understanding of the diet‐disease axis.

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A High Fat “Western‐style” Diet Induces AMD‐Like Features in Wildtype Mice

Keeling

Lynn

Koh

et al. 2022

Molecular Nutrition Food Res

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Scope: The intake of a "Western-style" diet rich in fats is linked with developing retinopathies including age-related macular degeneration (AMD). Wildtype mice are given a high fat diet (HFD) to determine how unhealthy foods can bring about retinal degeneration. Methods and results: Following weaning, female C57BL/6 mice are maintained on standard chow (7% kcal fat, n = 29) or a HFD (45% kcal fat, n = 27) for 12 months. Animals were sacrificed following electroretinography (ERG) and their eyes analyzed by histology, confocal immunofluorescence, and transmission electron microscopy. HFD mice become obese, but showed normal retinal function compared to chow-fed controls. However, diminished 𝜷3tubulin labeling of retinal cross-sections indicated fewer/damaged neuronal processes in the inner plexiform layer. AMD-linked proteins clusterin and TIMP3 accumulated in the retinal pigment epithelium (RPE) and Bruch's membrane (BrM). Neutral lipids also deposited in the outer retinae of HFD mice. Ultrastructural analysis revealed disorganized photoreceptor outer segments, collapsed/misaligned RPE microvilli, vacuoles, convoluted basolateral RPE infolds and BrM changes. Basal laminar-like deposits were also present alongside abnormal choroidal endothelial cells. Conclusions: We show that prolonged exposure to an unhealthy "Western-style" diet alone can recapitulate early-intermediate AMD-like features in wildtype mice, highlighting the importance of diet and nutrition in the etiology of sight-loss.

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Adherence to a Mediterranean diet, genetic susceptibility, and progression to advanced macular degeneration: a prospective cohort study

Abstract: Higher adherence to a Mediterranean diet was associated with reduced risk of progression to advanced AMD, which may be modified by genetic susceptibility. This trial was registered at clinicaltrials.gov as NCT00594672.

Cited by 106 publications

References 54 publications

Nutritional and Lifestyle Interventions for Age‐Related Macular Degeneration: A Review

Nutritional and Lifestyle Interventions for Age‐Related Macular Degeneration: A Review

Oxidative Stress and Dysfunctional Intracellular Traffic Linked to an Unhealthy Diet Results in Impaired Cargo Transport in the Retinal Pigment Epithelium (RPE)

A High Fat “Western‐style” Diet Induces AMD‐Like Features in Wildtype Mice

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