Adherence Patterns to National Comprehensive Cancer Network Guidelines for Referral of Women With Breast Cancer to Genetics Professionals

Stuckey, Ashley; Febbraro, T.; Laprise, Jessica; Wilbur, Jennifer Scalia; Lopes, Vrishali; Robison, Katina

doi:10.1097/coc.0000000000000073

Cited by 43 publications

(43 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Given that receipt of a referral from a healthcare provider was the strongest predictor of accessing genetic services in both our study and the recent McCarthy et al study [24], improving appropriate referral rates is critical. Our model indicates that diagnosis at or below age 45 and triple negative disease are both associated with referral, which suggests that healthcare providers recognize that these risk factors confer an increased likelihood of hereditary breast cancer, consistent with other research [31]. On the other hand, in contrast to a recent study [31], family history of cancer does not appear to strongly influence referral practices of healthcare providers in our study.…”

Section: Discussionsupporting

confidence: 87%

“…Our model indicates that diagnosis at or below age 45 and triple negative disease are both associated with referral, which suggests that healthcare providers recognize that these risk factors confer an increased likelihood of hereditary breast cancer, consistent with other research [31]. On the other hand, in contrast to a recent study [31], family history of cancer does not appear to strongly influence referral practices of healthcare providers in our study. Despite this conflicting finding, our results are consistent with studies that suggest inadequate elicitation and documentation of cancer family history in medical records [16,32,33].…”

Section: Discussionsupporting

confidence: 87%

See 1 more Smart Citation

Factors associated with genetic counseling and BRCA testing in a population-based sample of young Black women with breast cancer

Cragun

Bonner

Kim

et al. 2015

Breast Cancer Res Treat

View full text Add to dashboard Cite

Purpose Concerns about the potential for genomic advances to increase health disparities have been raised. Thus it is important to assess referral and uptake of genetic counseling (GC) and testing in minority populations at high risk for hereditary breast and ovarian cancer (HBOC). Methods Black women diagnosed with invasive breast cancer ≤ age 50 in 2009-2012 were recruited through the Florida State Cancer Registry 6-18 months following diagnosis and completed a baseline questionnaire. Summary statistics, Chi-square tests, and path modeling were conducted to examine which demographic and clinical variables were associated with referral and access to genetic services. Results Of the 440 participants, all met national criteria for GC yet only 224 (51%) were referred for or received GC and/or HBOC testing. Variables most strongly associated with healthcare provider referral for GC included having a college education (OR=2.1), diagnosis at or below age 45 (OR=2.0), and triple negative tumor receptor status (OR=1.7). The strongest association with receipt of GC and/or HBOC testing was healthcare provider referral (OR=7.9), followed by private health insurance at diagnosis (OR=2.8), and household income greater than $35,000 in the year prior to diagnosis (OR=2.0). Conclusions Study findings suggest efforts are needed to improve genetic services access among a population-based sample of high-risk Black women. These results indicate that socioeconomic factors and physician referral patterns contribute to disparities in access to genetic services within this underserved minority population.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 87%

Factors associated with genetic counseling and BRCA testing in a population-based sample of young Black women with breast cancer

Cragun

Bonner

Kim

et al. 2015

Breast Cancer Res Treat

View full text Add to dashboard Cite

show abstract

“…The variation in the application of the NCCN suggested tests is consistent with previous observations. 16,29,30 Adherence to established guidance for cancer management can have a positive effect on quality of care, and compliance with NCCN guidelines has been shown to improve survival by > 30%. 16,31 Altogether, a complete baseline diagnostic work-up is essential to optimize the treatment plan and monitor response in NDMM patients.…”

Section: Discussionmentioning

confidence: 99%

Connect MM Registry: The Importance of Establishing Baseline Disease Characteristics

Rifkin

Abonour

Terebelo

et al. 2015

Clinical Lymphoma Myeloma and Leukemia

View full text Add to dashboard Cite

“…Therefore, our finding that 30 % of women diagnosed with TNBC in this age group had a deleterious BRCA 1/2 mutation is not surprising. In clinical practice, available literature suggests that genetic counseling and testing is being underutilized in women who meet NCCN referral guidelines [17] but the magnitude to which counseling and testing is underperformed in minority populations has not been well investigated and is not addressed with this study.…”

Section: Discussionmentioning

confidence: 99%

Deleterious BRCA1/2 mutations in an urban population of Black women

Lynce

Smith

Stein

et al. 2015

Breast Cancer Res Treat

View full text Add to dashboard Cite

Information on the prevalence of deleterious BRCA1 and BRCA2 (BRCA1/2) mutations in clinic-based populations of Black women is limited. In order to address this gap, we performed a retrospective study to determine the prevalence of deleterious BRCA1/2 mutations, predictors of having a mutation, and acceptance of risk-reducing surgeries in Black women. In an urban unselected clinic-based population, we evaluated 211 self-identified Black women who underwent genetic counseling for hereditary breast–ovarian cancer syndrome. BRCA1/2 mutations were identified in 13.4 % of the participants who received genetic testing. Younger age at diagnosis, higher BRCA-PRO score, significant family history, and diagnosis of triple-negative breast cancer were associated with identification of a BRCA1/2 mutation. Of the affected patients found to have a deleterious mutation, almost half underwent prophylactic measures. In our study population, 1 in 7 Black women who underwent genetic testing harbored a deleterious BRCA1/2 mutation independent of age at diagnosis or family history.

show abstract

Adherence Patterns to National Comprehensive Cancer Network Guidelines for Referral of Women With Breast Cancer to Genetics Professionals

Cited by 43 publications

References 26 publications

Factors associated with genetic counseling and BRCA testing in a population-based sample of young Black women with breast cancer

Factors associated with genetic counseling and BRCA testing in a population-based sample of young Black women with breast cancer

Connect MM Registry: The Importance of Establishing Baseline Disease Characteristics

Deleterious BRCA1/2 mutations in an urban population of Black women

Contact Info

Product

Resources

About