Adherence of Type 1-Fimbriated <i>Escherichia coli</i> to Uroepithelial Cells

Geerlings, Suzanne E.; Meiland, Ruby; Lith, Emiel C. van; Brouwer, Eric; Gaastra, Wim; Hoepelman, Andy I. M.

doi:10.2337/diacare.25.8.1405

Cited by 119 publications

(84 citation statements)

References 33 publications

(29 reference statements)

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“…Glucose is detectable in airway secretions and may support the [24]. Escherichia coli adhesion to uroepithelial cells is increased in diabetic patients [25], and elevated urinary glucose levels support the growth of bacteria [26]. Lack of metabolic control, as measured by glycated haemoglobin, is a risk factor for bacteriuria [27].…”

Section: Discussionmentioning

confidence: 99%

Influence of diabetes and hyperglycaemia on infectious disease hospitalisation and outcome

2006

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Aims/hypothesis Diabetes mellitus is believed to increase susceptibility to infectious diseases. The effects of hyperglycaemia per se on infectious disease risk are unknown and the influence of diabetes on infectious disease outcome is controversial. Materials and methods We studied 10,063 individuals from the Danish general population, who were participants in The Copenhagen City Heart Study, over a follow-up period of 7 years. Risk of hospitalisation caused by any infectious disease, and subsequent risk of disease progression to death were estimated by Cox proportional hazards regression analysis. Results At baseline, 353 individuals reported having diabetes. During 71,509 person-years of follow-up, a total of 1,194 individuals were hospitalised because of an infection. The risk of pneumonia (adjusted hazard ratio [aHR] 1.75, 95% CI 1.23-2.48), urinary tract infection (aHR 3.03, 95% CI 2.04-4.49) and skin infection (aHR 2.43, 95% CI 1.49-3.95) was increased in subjects with diabetes compared with subjects without. Each 1 mmol/l increase in plasma glucose at baseline was associated with a 6-10% increased relative risk of pneumonia, urinary tract infection and skin infection after adjustment for other possible confounders. Among patients hospitalised for urinary tract infection, diabetic patients were at an increased risk of death at 28 days after admission compared with nondiabetic subjects (HR 3.90,. Conclusions/interpretation In the Danish general population, diabetes and hyperglycaemia are strong and independent risk factors for hospitalisation as a result of pneumonia, urinary tract infection and skin infection. Further, diabetes has a negative impact on the prognosis of urinary tract infection.

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Section: Discussionmentioning

confidence: 99%

Influence of diabetes and hyperglycaemia on infectious disease hospitalisation and outcome

2006

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“…It has been shown that the E coli with type 1 fimbriae adhere to the uroepithelial cells of diabetic women are twice as well as to the urothelium of nondiabetic controls. 36,37 Although in this study we did not flush the bladder after concluding a cystoscopy with D10, one could consider attempting to flush the D10 to decrease this adherence. Further study would be necessary to support this practice.…”

Section: Commentmentioning

confidence: 97%

Assessing ureteral patency using 10% dextrose cystoscopy fluid: evaluation of urinary tract infection rates

Siff

Unger

Jelovsek

et al. 2016

American Journal of Obstetrics and Gynecology

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BACKGROUND: Intravenous indigo carmine has routinely been used to confirm ureteral patency after urogynecologic surgery. Recent discontinuation of the dye has altered clinical practice. In the absence of indigo carmine, we have used 10% dextrose in sterile water (D10) as cystoscopic fluid to evaluate ureteral patency. Glucosuria has been associated with urinary tract infection (UTI) in vivo and significantly enhanced bacterial growth in vitro. The concern is that the use of D10 would mimic a state of glucosuria albeit transient and increase the risk of postoperative UTI. OBJECTIVES: The objectives of this study were to compare the rates of postoperative UTI and lower urinary tract (LUT) injuries between patients who underwent instillation of D10 vs normal saline at the time of intraoperative cystoscopy after urogynecological surgery. STUDY DESIGN: This was a retrospective cohort study of all women who underwent cystoscopic evaluation of ureteral patency at the time of urogynecological surgery from May through December 2014 at a tertiary care referral center. We compared patients who received D10 cystoscopy fluid vs those who used normal saline. Outcomes included UTI and diagnosis of ureteral or LUT injuries. UTI was diagnosed according to Centers for Disease Control and Prevention guidelines by symptoms alone, urine dipstick, urinalysis, or urine culture. Descriptive statistics compared

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“…Uropathogenic E. coli expressing type 1 fimbriae but no P fimbriae were twice as adherent to cells from women with diabetes as compared with cells collected from the women without diabetes (109). No differences in adherence were seen using the E. coli strain expressing no known uropathogenic adhesins or for the isolate expressing only P fimbriae (109). These data suggest that uroepithelial cells from women with diabetes may have intrinsic differences in nature and/or amount and/or affinity of binding receptors for type 1 fimbriae, such as uroplakins.…”

Section: Female Sexual Dysfunctionmentioning

confidence: 97%

“…Another recent study examined the ability of three representative clinical isolates of uropathogenic E. coli to adhere to uroepithelial cells collected from urine of women with and without diabetes (109). Uropathogenic E. coli expressing type 1 fimbriae but no P fimbriae were twice as adherent to cells from women with diabetes as compared with cells collected from the women without diabetes (109).…”

Section: Female Sexual Dysfunctionmentioning

confidence: 99%