Adherence of stem cell transplant recipients receiving glucocorticoid therapy to an exercise-based rehabilitation program

Morris, Gerwyn; Brueilly, Kevin E.; Scheetz, Janet S.; Lima, Marcos J.G. de

doi:10.1007/s00520-011-1352-0

Cited by 13 publications

(13 citation statements)

References 25 publications

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“…Functional capacity was evaluated using the 6-min walk test, 50-foot walking time, and repeated sit-to-stand movement. While one study reported no significant increase in functional capacity after physical exercise intervention [24], several other studies described a significant increase in functional capacity among the physical exercise group compared to the control group, following physical exercise intervention [11,12,21,22]. In our study, we showed that the highfrequency physical therapy group of allo-HSCT patients exhibited significantly less decline in muscle strength and functional capacity than the low-frequency physical therapy group [9].…”

Section: Physical Functioningcontrasting

confidence: 41%

“…The onset timing of physical exercise intervention for allo-HSCT patients varies, and can occur in 1 of 3 phases: conditioning (before HSCT) [11][12][13][14][15][16][17], post engraftment (after HSCT) [18,19], or hospital discharge phase [20][21][22][23][24]. Recently, physical exercise intervention has reportedly been increasingly initiated during the conditioning phase (chemotherapy and radiation therapy regimen).…”

Section: Physical Exercise Intervention Periodmentioning

confidence: 99%

“…Physical functioning has been evaluated through various methods that usually involve 3 aspects: aerobic capacity [11,13,18,20,23], muscle strength [11,13,18,21], and functional capacity [11,12,21,22,24]. In previous studies, aerobic capacity was evaluated using a treadmill or bicycle.…”

Section: Physical Functioningmentioning

confidence: 99%

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Physical Exercise for Patients Undergoing Allogeneic Haematopoietic Stem Cell Transplantation

Morishita¹

2013

nt J Phys Med Rehabil

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Section: Physical Functioningcontrasting

confidence: 41%

Section: Physical Exercise Intervention Periodmentioning

confidence: 99%

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Physical Exercise for Patients Undergoing Allogeneic Haematopoietic Stem Cell Transplantation

Morishita¹

2013

nt J Phys Med Rehabil

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“…The three studies that focused on exercise in an inpatient setting [4,5,14,21,33] showed that regular endurance training may not lead to an increase in endurance performance, but the loss of performance in the experimental groups was significantly lower than in control groups. Retrospective rehabilitation data analyzed by Morris et al [29] even did not show improvements in endurance performance either, whereas a subgroup of 40 % demonstrated improvement under glucocorticoid therapy. Non-randomized aerobic exercise intervention studies which started during the inpatient setting and were continued in the outpatient context, respectively, took place in the outpatient setting only, showed significantly enhanced endurance values in pre-/post-comparisons [7,13,18].…”

Section: Discussionmentioning

confidence: 91%

Exercise in the setting of hematopoietic stem cell transplantation

Wiskemann

2013

Eur Rev Aging Phys Act

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The procedure of hematopoietic stem cell transplantation (HSCT) is an intense treatment approach to cure patients from leukemia or lymphoma. Prior, during, and after HSCT, patients experience considerable physical and psychosocial distress. In light of the increasing number of successfully treated patients, the need is growing for evidence-based adjuvant therapy options, which are able to reduce treatment-related side effects and enhance the rehabilitation process. Exercise constitutes to be a promising intervention in this setting due to its multidimensional effectiveness. The purpose of this article was to review the current knowledge in the field of exercise and HSCT. Therefore, an electronic literature search in PubMed on the topic was performed. Twenty-nine articles could be identified and classified as relevant for this paper. Reviewed studies suggest that exercise training is an important therapeutic approach in the supportive care for transplant patients. Significant benefits from the exercise interventions have been reported for physical performance, quality of life (QoL), and fatigue status. Several other benefits, such as a more rapid immune recovery or alleviation of therapyrelated side effects have been reported in some studies. Future studies should address existing methodological problems, identify further effect levels of exercise and integrate a long-term perspective for the participants in the context of hematopoietic stem cell transplantation. Furthermore, potential biological pathways of exercise in HSCT patients should be investigated.

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“…Studies have demonstrated the feasibility of VO 2peak measurement in survivors of allogeneic HCT, [15][16][17] and the potential benefit of exercise intervention in ameliorating functional decline. [18][19][20] These data suggest a role for investigating VO 2peak measurement (and potentially, multimodality intervention to improve functional capacity) before the anticipated physiological stress of HCT.…”

Section: Introductionmentioning

confidence: 99%

Cardiopulmonary fitness in patients undergoing hematopoietic SCT: a pilot study

Wood

Deal

Reeve

et al. 2013

Bone Marrow Transplant

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Hematopoietic cell transplantation (HCT) is a life-saving treatment for patients with high-risk hematological malignancies. Prognostic measures to determine fitness for HCT are needed to inform decision-making and interventions. VO 2peak is obtained by measuring gas exchange during cycle ergometry and has not been studied as a prognostic factor in HCT. Thirty-two autologous and allogeneic HCT patients underwent VO 2peak and 6 Minute Walk (6MW) testing before HCT, and provided weekly symptom and health-related quality of life (HRQOL) assessments before HCT and concluding at Day 100. Twenty-nine patients completed pre-HCT testing. Pre-HCT VO 2peak was positively correlated with pre-HCT 6MW (r ¼ 0.65, Po0.001) and negatively correlated with number of chemotherapy regimens and months of chemotherapy. Patients with lower VO 2peak reported higher symptom burden and inferior HRQOL at baseline and during early post-HCT period. Patients with pre-HCT VO 2peak o16 mL/kg/min had higher risk of mortality post HCT (entire cohort: hazard ratio (HR) 9.1 (1.75-47.0), P ¼ 0.01; allogeneic HCT patients only: HR 6.70 (1.29-34.75), P ¼ 0.02) and more hospitalized days before Day 100 (entire cohort: median 33 vs 19, P ¼ 0.003; allogeneic HCT patients only: median 33 vs 21, P ¼ 0.004). VO 2peak pre-HCT is feasible and might predict symptom severity, HRQOL and mortality. Additional studies are warranted. Keywords: cardiopulmonary fitness; symptoms; health-related quality of life; hematopoietic SCT INTRODUCTIONFor patients with life-threatening hematological diseases, hematopoietic cell transplantation (HCT) offers the possibility of extended survival relative to standard conventional treatments. 1 The benefits of HCT are counterbalanced by the risk of treatmentrelated toxicity. Prognostic measures are needed to inform clinician and patient decision-making and to limit treatmentrelated risk. Direct cardiopulmonary fitness assessments such as VO 2peak are now available but have not yet been studied.Myeloablative allogeneic HCT has been associated with a 30-40% risk of treatment-related mortality (TRM). 2 Reduced intensity conditioning HCT is offered to older individuals and patients with comorbid illness, but this technique is still associated with a 20-30% risk of TRM. 3 Autologous HCT in older patients has been associated with a TRM risk exceeding 10%. 4 Subsets of patients after all types of transplants experience late health-related quality of life (HRQOL) deficits and functional impairment; 5 this effect is variable with other subgroups experiencing preserved patient-reported outcomes (PROs), relative to normative values. 6 Investigators and clinicians have attempted to determine who is 'fit' for transplant to inform pre-HCT counseling, selection of suitable HCT candidates and identification of vulnerable HCT recipients at risk for treatment-related complications. 7 Age remains the most commonly used surrogate variable for HCT

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Adherence of stem cell transplant recipients receiving glucocorticoid therapy to an exercise-based rehabilitation program

Cited by 13 publications

References 25 publications

Physical Exercise for Patients Undergoing Allogeneic Haematopoietic Stem Cell Transplantation

Physical Exercise for Patients Undergoing Allogeneic Haematopoietic Stem Cell Transplantation

Exercise in the setting of hematopoietic stem cell transplantation

Cardiopulmonary fitness in patients undergoing hematopoietic SCT: a pilot study

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