Adherence influencing factors in patients taking oral anticancer agents: A systematic review

Mathes, Tim; Pieper, Dawid; Antoine, Sunya-Lee; Eikermann, Michaela

doi:10.1016/j.canep.2014.03.012

Cited by 64 publications

(66 citation statements)

References 36 publications

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“…Few predictors of adherence to oral antineoplastic therapies were reliable and significant across studies, making definitive conclusions difficult to draw. These findings are consistent with those of prior reviews of adherence to oral antineoplastic therapy [8][9][10].…”

Section: Overview Of Findingssupporting

confidence: 82%

“…Although several reviews of adherence to oral antineoplastic therapies have been published [8,12,69,70], only a few were based on the systematic reporting criteria per PRISMA guidelines [10,11,68]. Furthermore, we examined observational, retrospective database, cohort, and randomized intervention studies to describe not only rates and correlates of adherence but also empirical efforts to date to improve proper administration of these oral agents.…”

Section: Overview Of Findingsmentioning

confidence: 99%

“…Most prior investigations have focused on adherence to oral endocrine therapy for breast cancer and medications for hematologic malignancies (namely chronic myeloid leukemia). Published reviews reveal quite variable, and sometimes alarmingly low, rates of adherence to these medications, even as low as 16% [9][10][11][12]. Moreover, studies show statistically significant associations between medication nonadherence and clinical and utilization outcomes, including cancer progression, more inpatient days, higher total health care spending, and worse survival [13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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A Systematic Review of Adherence to Oral Antineoplastic Therapies

et al. 2016

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Background. Oral antineoplastic therapies not only improve survival but also reduce the burden of care for patients. Yet patients and clinicians face new challenges in managing adherence to these oral therapies. We conducted a systematic literature review to assess rates and correlates of adherence to oral antineoplastic therapies and interventions aimed at improving adherence. Methods. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a comprehensive literature search of the Ovid MEDLINE database from January 1, 2003 to June 30, 2015, using relevant terminology for oral antineoplastic agents. We included observational, database, and intervention studies. At least two researchers evaluated each paper to ensure accuracy of results and determine risk of bias. Results. We identified 927 records from the search and screened 214 abstracts. After conducting a full-text review of 167

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Section: Overview Of Findingssupporting

confidence: 82%

Section: Overview Of Findingsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Systematic Review of Adherence to Oral Antineoplastic Therapies

et al. 2016

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“…It is estimated that compliance of cancer patients taking oral chemotherapeutics ranges between 20% and 100% [160]. Adverse events are the main cause for a impaired compliance, especially gastro-intestinal side effects are associated with smTKIs [161].…”

Section: Discussionmentioning

confidence: 99%

Variability in bioavailability of small molecular tyrosine kinase inhibitors

Herbrink

Nuijen

Schellens

et al. 2015

Cancer Treatment Reviews

111

104

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“…In a recent survey of 3,370 survivors, 40% reported moderate to high anxiety, and in approximately 20%, moderate to high levels of depression lasted up to 6 years post‐diagnosis (Inhestern et al, ). Depression can lead to serious consequences that include worsening quality of life (Higginson & Costantini, ), lower adherence to anticancer treatments (Mathes, Pieper, Antoine, & Eikermann, ), suicide (Henriksson, Isometsa, Hietanen, Aro, & Lonnqvist, ), prolonged hospital stays (Prieto et al, ), and reduced survival (Pinquart & Duberstein, ). Conventional management of depression and anxiety disorders is based on pharmacotherapy and psychotherapy.…”

Section: Introductionmentioning

confidence: 99%

Herbal medicine for depression and anxiety:Asystematic review with assessment of potential psycho‐oncologic relevance

Yeung

Hernandez

Mao

et al. 2018

Phytotherapy Research

173

113

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Anxiety and depression are prevalent among cancer patients, with significant negative impact. Many patients prefer herbs for symptom relief to conventional medications which have limited efficacy/side effects. We identified single-herb medicines that may warrant further study in cancer patients. Our search included PubMed, Allied and Complementary Medicine, Embase, and Cochrane databases, selecting only single-herb randomized controlled trials between 1996 and 2016 in any population for data extraction, excluding herbs with known potential for interactions with cancer treatments. One hundred articles involving 38 botanicals met our criteria. Among herbs most studied (≥6 randomized controlled trials each), lavender, passionflower, and saffron produced benefits comparable to standard anxiolytics and antidepressants. Black cohosh, chamomile, and chasteberry are also promising. Anxiety or depressive symptoms were measured in all studies, but not always as primary endpoints. Overall, 45% of studies reported positive findings with fewer adverse effects compared with conventional medications. Based on available data, black cohosh, chamomile, chasteberry, lavender, passionflower, and saffron appear useful in mitigating anxiety or depression with favorable risk-benefit profiles compared to standard treatments. These may benefit cancer patients by minimizing medication load and accompanying side effects. However, well-designed larger clinical trials are needed before these herbs can be recommended and to further assess their psycho-oncologic relevance.

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Adherence influencing factors in patients taking oral anticancer agents: A systematic review

Cited by 64 publications

References 36 publications

A Systematic Review of Adherence to Oral Antineoplastic Therapies

A Systematic Review of Adherence to Oral Antineoplastic Therapies

Variability in bioavailability of small molecular tyrosine kinase inhibitors

Herbal medicine for depression and anxiety:Asystematic review with assessment of potential psycho‐oncologic relevance

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