Adherence and persistence among patients with major depressive disorder enrolled in the vortioxetine tAccess Patient Support Program

Abstract

Objective: The tAccess Patient Support Program (PSP) is a personalized support program for patients prescribed vortioxetine therapy. We assessed the impact of the tAccess PSP on adherence to and persistence with vortioxetine among adult patients with major depressive disorder (MDD). Methods: A retrospective observational cohort study was conducted in patients with MDD receiving vortioxetine who were enrolled in the tAccess PSP. Eligible patients were 18 to 64 years of age and had 1 vortioxetine claim and 1 inpatient/outpatient medical MDD claim during the 12 months preceding or on the index date, defined as the date of the earliest vortioxetine claim. Study outcomes included medication adherence (proportion of days covered [PDC], adherent 80%) and persistence (the total number of days on therapy without a 30-day gap) at 90, 180, and 365 days. Additionally, persistence was reported for a subset of patients meeting the standardized Healthcare Effectiveness Data and Information Set (HEDIS) Antidepressant Medication Management (AMM) criteria (the percentage of adults aged 18-64 years who remained on an antidepressant for 84 days or 180 days), as defined by the National Committee for Quality Assurance. These data were reviewed alongside current HEDIS AMM data for commercially insured patients meeting the standardized metric. Results: The study identified a total of 2635 patients with an MDD diagnosis and 90 days of followup time and a subset of 2238 patients meeting HEDIS AMM criteria. Mean PDC among all patients with MDD was 0.78, with 58.3% of patients achieving PDC 80%. During the 90-day follow-up, 62.1% of patients with MDD were persistent on vortioxetine. Among the subset of patients who met HEDIS AMM criteria, persistence was 83.4% and 69.9% at 84 and 180 days, respectively. In comparison, in 2017, HEDIS AMM criteria for antidepressant persistence were met by 67.8% of commercially insured patients at 84 days and 51.8% at 180 days. Conclusions: These initial results, reviewed alongside recent available HEDIS AMM data, suggest that the tAccess PSP may be beneficial in addressing treatment adherence and persistence in patients with MDD.

Adherence to, and Persistence of, Antidepressant Therapy in Patients with Major Depressive Disorder: Results from a Population-based Study in Italy

“…In patients who felt well enough to discontinue treatment, those discontinuing their antidepressants had a higher risk of relapse of depression at one year compared to patients who continued antidepressant treatment [ 53 ]. In considering other means of optimizing adherence, a recent study investigating the use of a personal support program (tAccess Patient Support Program) for patients prescribed vortioxetine therapy reported adherence of 83% and 70% at 84 and 180 days, respectively, suggesting that the intervention may help to increase adherence and help ensure that patients complete their planned therapy [ 54 ]. The present study further strengthens the need to carry out additional research on antidepressants and identify clinical and other factors that influence adherence and persistence to therapy.…”