Adherence among Rural HIV-Infected Patients in the Deep South

Abstract

Treatment-experienced patients enrolled in ADAP are less likely to be adherent. A QD PI-based MTR may result in comparable adherence to an STR in a rural HIV-infected population.

Barriers to HIV Medication Adherence as a Function of Regimen Simplification

“…In two observational studies, no difference was found between STR and other single-dose MTR among patients initiating ART [24] or among those who switched from STR to MTR for cost reasons [25]. Further complicating drawing conclusions from this literature are findings from a recent study by Tennant et al [26], in which MTR were associated with better adherence than STR based on clinic refill records.…”

“…If patients with lower anticipated adherence had a higher tendency of being assigned STR, the improvement in adherence brought by STR might have been attenuated. Variations in measures of adherence across studies may also account for discrepancies in the literature [17, 20–22, 24] [16] [26] [18, 19]. Taken together, the inconsistent relationship between STR and adherence obscures inferences that we can draw about the role of treatment simplification on adherence.…”

Does the Polypill Improve Patient Adherence Compared to Its Individual Formulations? A Systematic Review

“…Ingredients (2, 3 Table 4 summarizes methods for measuring adherence that were used in the selected articles (n = 67). Most of the studies (n = 62; 93%) relied only on one method; however, five studies [35,50,59,79,82] combined two different methods to assess medication adherence. The applied methods could be divided into two broad categories: subjective (e.g., patient interviews and self-reporting) and indirect (e.g., pill counts, methods using prescription fills, electronic monitoring) [75].…”

“…High adherence: MPR > 0.8 n = 30 [5,[31][32][33]36,[39][40][41]43,44,[49][50][51]54,55,57,58,60,[62][63][64]67,80,82,84,86,89,91,94,95] Proportion of days covered (PDC) General…”

“…Adherent: not missing any drug dose or no more than 2 doses per week, received the correct dosage of the medication, and not interrupting their treatment. n = 5 [45,48,50,52,85] Uses information given by the patient who performs self-assessment of adherence on a scale 0-100.…”