ADHDgene: a genetic database for attention deficit hyperactivity disorder

Abstract

With a worldwide prevalence of ∼5%, attention deficit hyperactivity disorder (ADHD) has become one of the most common psychiatric disorders. The polygenetic nature of ADHD indicates that multiple genes jointly contribute to the development of this complex disease. Studies aiming to explore genetic susceptibility of ADHD have been increasing in recent years. There is a growing need to integrate the genetic data from various genetic studies to provide a comprehensive data set and uniform access for convenience of in-depth data mining. So far, there has been no such effort for ADHD. To address the genetic complexity of ADHD, we developed the ADHDgene database by integrating ADHD-related genetic factors by profound literature reading. Based on the data from the literature, extended functional analysis, including linkage disequilibrium analysis, pathway-based analysis and gene mapping were performed to provide new insights into genetic causes of ADHD. Moreover, powerful search tools and a graphical browser were developed to facilitate the navigation of the data and data connections. As the first genetic database for ADHD, ADHDgene aims to provide researchers with a central genetic resource and analysis platform for ADHD and is freely available at http://adhd.psych.ac.cn/.

Neurodevelopmental disorders associated with dosage imbalance ofZBTB20correlate with the morbidity spectrum of ZBTB20 candidate target genes

“…Schizophrenia was included since it is used more frequently in the databases than the less specific term psychosis. We searched for gene–phenotype associations in the following databases: OMIM,24 University of Copenhagen DISEASES database,20 UniprotKB,25 Genecards,26 Autism Genetic Database,27 Genetic Association database,28 HuGEnet,29 Schizophrenia Gene Resource,30 AutDB,31 AutismKB,32 Genatlas,33 Huge GWAS,29 ADHDgene34 and Sfari 35. To minimise the number of false gene-name mappings, we kept only mappings where the preferred name corresponded to the name used in the database.…”

Neurobiologische Grundlagen der Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung

“…2 Übersicht über die am meisten untersuchten Gene im Zusammenhang mit ADHS in Anlehnung an ADHDgene (vgl. [145]). …”

“…2. Diese ist an aktuelle Daten der wissenschaftlichen Datenbank ADHDgene angelehnt (siehe hierzu[145]), die im Internet frei verfügbar ist (siehe: http://adhd. psych.ac.cn/).…”

Neurocarta: aggregating and sharing disease-gene relations for the neurosciences

“…While these different resources overlap in their disease coverage and data sources, they are also complementary in that each of the curation teams making the annotations has different criteria for inclusion and different biases. Other databases are dedicated to specific disorders, these include the Simons Foundation Autism Research Initiative Gene Database (SFARI Gene) for autism [5], PDGene for Parkinson’s disease [6], Alzgene for Alzheimer’s disease [7], MSGene for multiple sclerosis [8], ADHDgene for Attention Deficit Hyperactivity Disorder [9], and CADgene for Coronary Artery Disease [10]. …”