ADHD desynchronizes brain activity during watching a distracted multi-talker conversation

Salmi, Juha; Metwaly, Mostafa; Tohka, Jussi; Alho, Kimmo; Leppämäki, Sami; Tani, Pekka; Koski, Anniina; Vanderwal, Tamara; Laine, Matti

doi:10.1016/j.neuroimage.2019.116352

Cited by 32 publications

(32 citation statements)

References 68 publications

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“…Of the myriad potential ways to analyze data from naturalistic paradigms, we restricted our approach here to functional connectivity because it can be applied equally to both resting-state and movie-watching data, providing a straightforward way to test for differences between conditions. However, analyses that exploit the presence of a time-locked “ground truth” in naturalistic paradigms, such as inter-subject representational similarity analysis ( Finn et al, 2020 ), an extension of the inter-subject correlation family of approaches ( Hasson et al, 2004 ; Nastase et al, 2019 ), might prove even more sensitive to trait-level variability in both normative ( van Baar et al, 2019 ) and clinical populations ( Hasson et al, 2009 ; Salmi et al, 2013 ; Byrge et al, 2015 ; Bolton et al, 2018 ; Salmi et al, 2020 ). Because these and other activation-based approaches (e.g., Venkatesh et al, 2020 ) allow us to interpret spatiotemporal activity patterns in the context of stimulus features, they open the door to models that are not only predictive ( what are the relationships between brain function and behavior), but also deepen our understanding of how and why individuals show distinct brain responses to the same information, and how this relates to trait-level phenotypes.…”

Section: Discussionmentioning

confidence: 99%

Movie-watching outperforms rest for functional connectivity-based prediction of behavior

2021

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A major goal of human neuroscience is to relate differences in brain function to differences in behavior across people. Recent work has established that whole-brain functional connectivity patterns are relatively stable within individuals and unique across individuals, and that features of these patterns predict various traits. However, while functional connectivity is most often measured at rest, certain tasks may enhance individual signals and improve sensitivity to behavior differences. Here, we show that compared to the resting state, functional connectivity measured during naturalistic viewing—i.e., movie watching—yields more accurate predictions of trait-like phenotypes in the domains of both cognition and emotion. Traits could be predicted using less than three minutes of data from single video clips, and clips with highly social content gave the most accurate predictions. Results suggest that naturalistic stimuli amplify individual differences in behaviorally relevant brain networks.

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Section: Discussionmentioning

confidence: 99%

Movie-watching outperforms rest for functional connectivity-based prediction of behavior

2021

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“…However, analyses that exploit the presence of a time-locked "ground truth" in naturalistic paradigms, such as inter-subject representational similarity analysis (Finn et al, 2020), an extension of the inter-subject correlation family of approaches (Hasson et al, 2004;Nastase et al, 2019), might prove even more sensitive to trait-level variability in both normative (van Baar et al, 2019) and clinical populations (Hasson et al, 2009;Salmi et al, 2013;Byrge et al, 2015;Bolton et al, 2018;Salmi et al, 2020). Because these and other activation-based approaches allow us to interpret spatiotemporal activity patterns in the context of stimulus features, they open the door to models that are not only predictive (what are the relationships between brain function and behavior), but also deepen our understanding of how and why individuals show distinct brain responses to the same information, and how this relates to trait-level phenotypes.…”

Section: Implications For Future Workmentioning

confidence: 99%

Movie-watching outperforms rest for functional connectivity-based prediction of behavior

Finn

Bandettini

2020

Preprint

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A major goal of human neuroscience is to relate differences in brain function to differences in behavior across people. Recent work has established that whole-brain functional connectivity patterns are relatively stable within individuals and unique across individuals, and that features of these patterns predict various traits. However, while functional connectivity is most often measured at rest, certain tasks may enhance individual signals and improve sensitivity to behavioral differences. Here, we show that compared to the resting state, functional connectivity measured during naturalistic viewing—i.e., movie watching—yields more accurate predictions of trait-like phenotypes in the both cognitive and emotional domains. Traits could be predicted using less than three minutes of data from single video clips, and clips with highly social content gave the most accurate predictions. Results suggest that naturalistic stimuli amplify individual differences in behaviorally relevant brain networks.

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“…In terms of brain measures, inattention and hyperactivity have shown associations with gray matter volume in different areas of the brain in a population-based study ( Albaugh et al. 2017 ), and Salmi et al. (2020 ) found different dimensional associations between ISC and inattention and hyperactivity in their adult control group.…”

Section: Discussionmentioning

confidence: 99%

“…In adults without attention deficit/hyperactivity disorder (ADHD), inattentive and hyperactive/impulsive traits have been associated with interindividual synchrony of blood oxygen level dependent (BOLD) signal during viewing of a naturalistic movie stimuli ( Salmi et al. 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…Previous work has examined the association between a clinical diagnosis of ADHD and ISC during video viewing. In 1 adult study ( Salmi et al. 2020 ), controls displayed more synchronized brain activity than ADHD individuals in the lateral and medial occipital cortex, precuneus, temporoparietal junction, superior temporal cortex, and—when speech or music distractors were added to the movie—the posterior parietal cortex.…”

Section: Introductionmentioning

confidence: 99%

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Inattentive and hyperactive traits differentially associate with interindividual functional synchrony during video viewing in young children without ADHD

Tansey

Graff

Rohr

et al. 2022

Cerebral Cortex Communications

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Inattention and hyperactivity present on a spectrum and may influence the way children perceive and interact with the world. We investigated whether normative variation in inattentive and hyperactive traits was associated with differences in brain function while children watched clips from an age-appropriate television program. fMRI data and parent reports of inattention and hyperactivity traits were collected from 81 children 4–7 years of age with no parent-reported diagnoses. Data were analyzed using inter-subject correlations in mixed effects models to determine if inattentive and hyperactive traits were associated with idiosyncrasy of fMRI response to the video. We hypothesized that pairs of children with higher average inattention and hyperactivity scores would show less inter-individual brain synchrony to one another than pairs with lower average scores on these traits. Video watching engaged widespread visual, auditory, default mode and dorsal prefrontal regions. Inattention and hyperactivity were separably associated with inter-subject correlation in many of these regions. Our findings suggest that the spectrum of inattention and hyperactivity traits in children without ADHD are differentially associated with neural processing of naturalistic video stimuli, which may have implications for understanding how children with different levels of these traits process audiovisual information in unconstrained conditions.

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ADHD desynchronizes brain activity during watching a distracted multi-talker conversation

Cited by 32 publications

References 68 publications

Movie-watching outperforms rest for functional connectivity-based prediction of behavior

Movie-watching outperforms rest for functional connectivity-based prediction of behavior

Movie-watching outperforms rest for functional connectivity-based prediction of behavior

Inattentive and hyperactive traits differentially associate with interindividual functional synchrony during video viewing in young children without ADHD

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