ADEVO: Proof-of-concept of Adenovirus Directed EVOlution by random peptide display on the fiber knob
Erwan Sallard,
Julian Fischer,
Nissai Beaude
et al.
Abstract:Directed evolution of viral vectors involves the generation of randomized libraries followed by artificial selection of improved variants. Directed evolution only yielded limited results in adenovirus vector (AdV) development until now, mainly due to insufficient complexities of randomized libraries.Clinical applications of AdVs as gene therapy or oncolytic vectors are still hampered by the predetermined tropism of natural types. To overcome this challenge, we hypothesized that the technology of randomized pep… Show more
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