Adequate dietary vitamin D and calcium are both required to reduce bone turnover and increased bone mineral volume

Lee, Alice M. C.; Sawyer, Rebecca; Moore, Abby; Morris, Howard A.; O’Loughlin, Peter; Anderson, Paul

doi:10.1016/j.jsbmb.2013.11.009

Cited by 21 publications

(12 citation statements)

References 17 publications

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“…We also observed that 1% Ca supplement improved the BV/TV of the distal femur. It has been shown that salmon bone powder improved the BV/TV of OVX rats [29,30]. The observed increases in BV/TV, Tb.Th, Tb.N and Ct.Th, and the decrease in BSA/BV and Tb.Sp indicated an improved overall bone strength and tibial trabecular bone density.…”

Section: Discussionmentioning

confidence: 99%

Calcium Supplement Derived from Gallus gallus domesticus Promotes BMP-2/RUNX2/SMAD5 and Suppresses TRAP/RANK Expression through MAPK Signaling Activation

et al. 2017

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The present study evaluated the effects of a calcium (Ca) supplement derived from Gallus gallus domesticus (GD) on breaking force, microarchitecture, osteogenic differentiation and osteoclast differentiation factor expression in vivo in Ca-deficient ovariectomized (OVX) rats. One percent of Ca supplement significantly improved Ca content and bone strength of the tibia. In micro-computed tomography analysis, 1% Ca supplement attenuated OVX- and low Ca-associated changes in bone mineral density, trabecular thickness, spacing and number. Moreover, 1% Ca-supplemented diet increased the expression of osteoblast differentiation marker genes, such as bone morphogenetic protein-2, Wnt3a, small mothers against decapentaplegic 1/5/8, runt-related transcription factor 2, osteocalcin and collagenase-1, while it decreased the expression of osteoclast differentiation genes, such as thrombospondin-related anonymous protein, cathepsin K and receptor activator of nuclear factor kappa B. Furthermore, 1% Ca-supplemented diet increased the levels of phosphorylated extracellular signal-regulated kinase and c-Jun N-terminal kinase. The increased expression of osteoblast differentiation marker genes and activation of mitogen-activated protein kinase signaling were associated with significant increases in trabecular bone volume, which plays an important role in the overall skeletal strength. Our results demonstrated that 1% Ca supplement inhibited osteoclastogenesis, stimulated osteoblastogenesis and restored bone loss in OVX rats.

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Section: Discussionmentioning

confidence: 99%

Calcium Supplement Derived from Gallus gallus domesticus Promotes BMP-2/RUNX2/SMAD5 and Suppresses TRAP/RANK Expression through MAPK Signaling Activation

et al. 2017

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“…137 The genetic component is emerging as a strong predictor, as polymorphisms within various genes involved in the metabolic pathway of VitD (VitD-binding protein, megalin, cubilin, CYP27B1, CYP24A1, VDR) may explain not only a substantial percentage of the interindividual variability of 25-(OH)D, but also its association with major clinical outcomes 5,18,67,143,144 Several recently published reports challenge the established "normal" cut-off point for 25-(OH)D sufficiency. 19,21 According to the NHANES 2005-2006 findings, the mean 25-(OH)D concentration is approximately 24 ng/mL in most age groups. Furthermore, the US Institute of Medicine (IOM) in 2011 concluded that serum 25-(OH)D levels >20 ng/mL are sufficient for almost the entire (97.5%) population, at least as regards Caucasians.…”

Section: 55mentioning

confidence: 99%

“…11 This rationale is based on maximal intestinal calcium absorption and nadir concentrations of parathyroid hormone (PTH), reported to be achievable at 25-(OH)D levels of approximately 30-40 ng/mL, [12][13][14][15] and is underscored by the updated recommendations of the US Endocrine Society. 1 However, both tenets have recently been challenged: [16][17][18][19] The boundary for clinically relevant VitD deficiency, characterized by osteopenia and rickets/ osteomalacia, has traditionally been set at 10 ng/mL 25-(OH)D, 17,20 a point recently disputed by the US Endocrine Society, that has raised the VitD deficiency threshold to 20 ng/mL 25-(OH)D. 1 25-(OH)D "insufficiency" spans the range between the frank deficiency threshold and the lower normal level (traditionally 10-30 ng/mL), indicating inadequate stores for optimal VitD functions, but generally not associated with overt clinical symptoms. 21 VitD overall status in vivo is best estimated by the concentration of serum total 25-(OH)D, i.e.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D levels in a large Mediterranean cohort: reconsidering normal cut-off values

Katrinaki

Kampa

Margioris

et al. 2016

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“…Furthermore, what is also essential is the para-and autocrine control by cytokines, growth factors and via the nervous system (Togari et al 2008) The literature has well documented the relationships between bone mineral density (BMD) and bone mass (BMC), and vitamin D and calcium (Uusi-Rasi et al 2013;Lee et al 2014). Some studies point to another important relationship between the state of bone tissue (the occurrence of osteoporosis), and the lipid level in the blood serum (Brownbill et al 2006;Ghadiri-Anari et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Body mass index, general fatness, lipid profile and bone mineral density in young women and men

Kopiczko

Gryko

2017

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AbstrAct:The bone tissue is metabolically active. Throughout the entire life, it undergoes changes in the form of bone resorption processes which are successive, with the participation of the resorbing cells and bone formation processes. The aim of the study was to evaluate mineral density and bone mass tissue and the lipid profile, BMI, total body fat in young females and males. The study involved 100 people (50 females and 50 males) studying in Warsaw at the age of 23,2 ± 4,0 years. The densitometry method of the forearm was used for the assessment of bone mineral density (BMD) and bone mass (BMC). The method of bioelectrical impedance was used for the assessment of body components. Basic body dimensions and indicators were assessed using anthropometric measurements. Body height, body mass and the needs for the densitometry study of the forearm were measured. The total cholesterol concentration was determined in the blood serum using diagnostic kits, as well as high-density lipoprotein (HDL-C) and triglycerides. The concentration of the low-density lipoprotein (LDL-C) was calculated. While in men the occurrence of a significant, positive correlation was stated between the concentration of the HDL cholesterol fraction and the mineral density and T-score index in the ultra-distal point, the analysis of the compounds of mineral density (BMD), bone mass (BMC) of the forearm, T-score index with somatic features in women showed a significant, positive relation between the body weight and the bone mass mineral density and T-score indicator in the proximal point. Also, a significant weak, positive correlation was observed between the BMI, the mineral density and T-score indicator in the proximal point. In men, the occurrence of significant, positive correlations was stated between the body weight and BMC, BMD, T-score indicator in the proximal point of the forearm bone and ultra-distal point. Similar relations were observed between the BMI, mineral density, T-score and bone mass in the proximal point and in the ultra-distal point. Based on several noted weak, positive correlations between the lipid profile and BMD, the results of this study of women and men cannot unequivocally indicate the dependence of the bone tissue state on the lipid level in the blood serum of young women and men. Therefore, the issues raised require further investigation.

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Adequate dietary vitamin D and calcium are both required to reduce bone turnover and increased bone mineral volume

Cited by 21 publications

References 17 publications

Calcium Supplement Derived from Gallus gallus domesticus Promotes BMP-2/RUNX2/SMAD5 and Suppresses TRAP/RANK Expression through MAPK Signaling Activation

Calcium Supplement Derived from Gallus gallus domesticus Promotes BMP-2/RUNX2/SMAD5 and Suppresses TRAP/RANK Expression through MAPK Signaling Activation

Vitamin D levels in a large Mediterranean cohort: reconsidering normal cut-off values

Body mass index, general fatness, lipid profile and bone mineral density in young women and men

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