Adenylate cyclase in the developing rat cerebral cortex and olfactory bulb

Cousin, X.; Davrainville, J.L.

doi:10.1007/bf02003992

Cited by 3 publications

(2 citation statements)

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“…Previous reports (Harden et al, 1977;Cousin and Davrainville, 1980) have shown that adenylate cyclase activity is very low in neonatal rat brain and rapidly increases between 2 and 3 weeks of age. In adult brain, transient increases in cyclic AMP levels have been observed during hypoxia or ischemia and the early recovery phase, as described above.…”

Section: Discussionmentioning

confidence: 87%

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Changes in Levels of Purine and Pyrimidine Nucleotides During Acute Hypoxia and Recovery in Neonatal Rat Brain

Hisanaga

Oda

Kogure

1986

Journal of Neurochemistry

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Neonatal rat brains were examined for changes in levels of ATP, ADP, AMP, cyclic AMP, GTP, GDP, UTP, UDP, UMP, and CTP during exposure to 100% nitrogen for 20 min and subsequent recovery in air. During hypoxia, ATP, GTP, UTP, and CTP levels and the GTP/GDP ratio decreased to 38, 50, 26, 21, and 21%, respectively, of control levels. No significant change in cyclic AMP level was observed. The decrease in the total uridine nucleotide pool during hypoxia was markedly greater (to 53% of control levels) than that in the total adenine nucleotide pool (to 92% of control levels). During recovery, ATP and GTP levels were rapidly and almost completely restored. On the other hand, CTP levels returned slowly to control values after a 2-h recovery period. Restoration of the UTP level was slow and incomplete (87% of the control value even after a 3-h recovery period). The GTP/GDP ratio also did not return to normal. These data suggest that hypoxic insult to the neonate may have an effect on the synthesis of nucleotidyl sugars, phospholipids, and proteins in the brain, resulting in significant problems with developmental processes of the brain. The present study also showed that the delayed restorations of the UTP level and the GTP/GDP ratio were not seen in the brains of adult rats subjected to acute severe hypoxic insult.

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Section: Discussionmentioning

confidence: 87%

“…The ratio of GTP to GDP is also high in neonatal rat brain. Adenylate cyclase (EC 4.6.1.1) activity in neonatal rat brain is very low (Harden et al, 1977;Cousin and Davrainville, 1980). Compared with results in adults, hypoxic insult to a neonate may cause different changes in the metabolism of these nucleo-tides and cyclic AMP in the brain.…”

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confidence: 99%