Adenyl Cyclase Hormone Responses of Certain Human Endocrine Tumors*

Schorr, Immanuel; Hinshaw, H. T.; Cooper, Margaret A.; Mahaffee, D D; Ney, Robert L.

doi:10.1210/jcem-34-3-447

Cited by 37 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other endocrine tumors harbored ectopic GPCR, including pheochromocytomas in which ectopic expression of glucagon receptor and HTR4 were demonstrated (130,131). A female patient with pheochromocytoma experienced a life-threatening hypertension crisis after metoclopramide administration.…”

Section: European Journal Of Endocrinologymentioning

confidence: 99%

Multiple aberrant hormone receptors in Cushing's syndrome

Ghorayeb

Bourdeau

Lacroix

2015

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

Section: European Journal Of Endocrinologymentioning

confidence: 99%

Multiple aberrant hormone receptors in Cushing's syndrome

Ghorayeb

Bourdeau

Lacroix

2015

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…The aberrant stimulation of AC in other human endocrine tumors has been explored initially by Robert Ney and colleagues (366). The aberrant stimulation of AC in other human endocrine tumors has been explored initially by Robert Ney and colleagues (366).…”

Section: Ectopic/abnormal Hormone Membrane Receptors In Nonadrementioning

confidence: 99%

Ectopic and Abnormal Hormone Receptors in Adrenal Cushing’s Syndrome*

et al. 2001

View full text Add to dashboard Cite

The mechanism by which cortisol is produced in adrenal Cushing's syndrome, when ACTH is suppressed, was previously unknown and was referred to as being "autonomous." More recently, several investigators have shown that some cortisol and other steroid-producing adrenal tumors or hyperplasias are under the control of ectopic (or aberrant, illicit, inappropriate) membrane hormone receptors. These include ectopic receptors for gastric inhibitory polypeptide (GIP), beta-adrenergic agonists, or LH/hCG; a similar outcome can result from altered activity of eutopic receptors, such as those for vasopressin (V1-AVPR), serotonin (5-HT4), or possibly leptin. The presence of aberrant receptors places adrenal cells under stimulation by a trophic factor not negatively regulated by glucocorticoids, leading to increased steroidogenesis and possibly to the proliferative phenotype. The molecular mechanisms responsible for the abnormal expression and function of membrane hormone receptors are still largely unknown. Identification of the presence of these illicit receptors can eventually lead to new pharmacological therapies as alternatives to adrenalectomy, now demonstrated by the long-term control of ectopic P-AR- and LH/hCGR-dependent Cushing's syndrome by propanolol and leuprolide acetate. Further studies will potentially identify a larger diversity of hormone receptors capable of coupling to G proteins, adenylyl cyclase, and steroidogenesis in functional adrenal tumors and probably in other endocrine and nonendocrine tumors.

show abstract

“…The 'sponge' hypothesis In 1964, Unger, Lochner and Eisentraut postulated that tumours associated with ectopie humoral syndromes adsorb hormones from the circulation and then release them on cell death. Measurements of arterio-venous gradients provide some support for the hypothesis in that some tumours do appear to be capable of hormone adsorption (L. H. Rees, unpublished observations), possibly due to the existence of 'ectopie' receptors on the tumour surface (Schorr, Rathnam, Saxena & Ney, 1971;Schorr, Hinshaw, Cooper, Mahaffee & Ney, 1972). Nevertheless, this mechanism cannot fully account for ectopie hormone production since 'ectopie' hormone synthesis by tumour tissue has been unequivocally demonstrated in several instances, and it cannot explain some findings such as the secretion of HPL by lung tumours in men.…”

Section: Postulated Mechanisms Of Ectopic Hormone Secrftionmentioning

confidence: 83%