Adenoviruses C in non-hospitalized Mexican children older than five years of age with acute respiratory infection

Rosete, Dora; Manjarrez, María Eugenia; Barrón, Blanca Lilia

doi:10.1590/s0074-02762008000200012

Cited by 26 publications

(19 citation statements)

References 40 publications

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“…These methods will be of direct use during outbreaks of a specific type when decision making is depended on these results. This method has been used by others for the detection the hexon gene region of Adenovirus genome [7,14,15]. Similar findings have been reported by Helen Sarantis et al, who tested hexon gene (HVR-7) that was able to detect all serotypes of human adenoviruses known at that time with high sensitivity [17].…”

Section: Resultssupporting

confidence: 64%

Molecular Diagnosis of Human Adenovirus in Children with Upper Respiratory Tract Infections

Khalaf¹,

Fadhil²,

Auf³

et al. 2017

IOSRJPBS

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Section: Resultssupporting

confidence: 64%

Molecular Diagnosis of Human Adenovirus in Children with Upper Respiratory Tract Infections

Khalaf¹,

Fadhil²,

Auf³

et al. 2017

IOSRJPBS

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“…In all four regions (northern coast, central coast, southern highlands, and jungle) subgroup C predominated, subgroup B was the second most common, and subgroup E was the least common (except for the central coast where B and E were identified in the same number). Likewise, the bordering country of Brazil [41], [56], as well as the non-bordering Latin American countries of Mexico [57] and Cuba [45], also observed a predominance of subgroup C. On the other hand, two other countries bordering Peru, Colombia [38], [58] and Argentina [43], noted a predominance of subgroup B.…”

Section: Discussionmentioning

confidence: 99%

Adenovirus Respiratory Tract Infections in Peru

Ampuero

Ocaña²,

Gómez

et al. 2012

PLoS ONE

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BackgroundCurrently, there is a paucity of data regarding human adenovirus (HAdv) circulation in Andean regions of South America. To address this shortcoming, we report the clinical, phylogenetic, and epidemiologic characteristics of HAdv respiratory tract infection from a large sentinel surveillance study conducted among adults and children in Peru.Methods/Principal FindingsOropharyngeal swabs were collected from participants visiting any of 38 participating health centers, and viral pathogens were identified by immunofluorescence assay in cell culture. In addition, molecular characterization was performed on 226 randomly selected HAdv samples. Between 2000 and 2010, a total of 26,375 participants with influenza-like illness (ILI) or severe acute respiratory infection (SARI) were enrolled in the study. HAdv infection was identified in 2.5% of cases and represented 6.2% of all viral pathogens. Co-infection with a heterologous virus was found in 15.5% of HAdv cases. HAdv infection was largely confined to children under the age of 15, representing 88.6% of HAdv cases identified. No clinical characteristics were found to significantly distinguish HAdv infection from other respiratory viruses. Geographically, HAdv infections were more common in sites from the arid coastal regions than in the jungle or highland regions. Co-circulation of subgroups B and C was observed each year between 2006 and 2010, but no clear seasonal patterns of transmission were detected.Conclusions/SignificanceHAdv accounted for a significant fraction of those presenting with ILI and SARI in Peru and tended to affect the younger population disproportionately. Longitudinal studies will help better characterize the clinical course of patients with HAdv in Peru, as well as determine the role of co-infections in the evolution of illness.

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“…They are important human pathogens, particularly in the immunocompromised (20,21), and are reported primarily as respiratory agents; HAdV-C infections may be mild or asymptomatic (7) or cause serious acute respiratory disease (5,7,(15)(16)(17)32).…”

mentioning

confidence: 99%

“…As an example, species C members have constituted up to 28.5% of the typed isolates in a epidemiologic survey of HAdV acute respiratory infections of children in South America in a 4-year period (17), indicating a significant presence in that population. Another report observed that 23% of the pathogens causing acute respiratory disease in 100 Mexican children were HAdVs, with all of the isolates identified as species C exclusively (32), including HAdV-C6. This was also observed in a recent survey of Malaysian HAdV respiratory tract infections, which noted that species C were the most commonly isolated HAdV among pediatric patients in a 7-year period (1).…”

mentioning

confidence: 99%

Computational Analysis of Two Species C Human Adenoviruses Provides Evidence of a Novel Virus

et al. 2011

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Human adenovirus C (HAdV-C) species are a common cause of respiratory infections and can occasionally produce severe clinical manifestations. A deeper understanding of the variation and evolution in species HAdV-C is especially important since these viruses, including HAdV-C6, are used as gene delivery vectors for human gene therapy and in other biotechnological applications. Here, the full-genome analysis of the prototype HAdV-C6 and a recently identified virus provisionally termed HAdV-C57 are reported. Although the genomes of all species HAdV-C members are very similar to each other, the E3 region, hexon and fiber (ten proteins total) present a wide range of identity values at the amino acid level. Studies of these viruses in comparison to the other three HAdV-C prototypes (1, 2, and 5) comprise a comprehensive analysis of the diversity and conservation within HAdV-C species. HAdV-C6 contains a recombination event within the constant region of the hexon gene. HAdV-C57 is a recombinant virus with a fiber gene nearly identical to HAdV-C6 and a unique hexon distinguished by its loop 2 motif.

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Adenoviruses C in non-hospitalized Mexican children older than five years of age with acute respiratory infection

Abstract: Adenoviruses (AdV)

Cited by 26 publications

References 40 publications

Molecular Diagnosis of Human Adenovirus in Children with Upper Respiratory Tract Infections

Molecular Diagnosis of Human Adenovirus in Children with Upper Respiratory Tract Infections

Adenovirus Respiratory Tract Infections in Peru

Computational Analysis of Two Species C Human Adenoviruses Provides Evidence of a Novel Virus

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