Adenovirus Vaccines in Military Recruit Populations: A Cost-Benefit Analysis

Collis, Peter B.; Dudding, Burton A.; Winter, Phlllip E.; Russell, Philip K.; Buescher, Edward L.

doi:10.1093/infdis/128.6.745

Cited by 29 publications

(12 citation statements)

References 9 publications

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“…Several cost-benefit analyses have demonstrated the benefits of the adenovirus vaccination program [31][32][33]. The first, published in 1973, estimated cost savings for the Army during the years 1970 and 1971.…”

Section: Introductionmentioning

confidence: 99%

“…The first, published in 1973, estimated cost savings for the Army during the years 1970 and 1971. It was estimated that the vaccines prevented 26,979 cases of FRI within the Army over the 2 years at a cost of $279 per illness, for an ultimate savings over vaccination program expenses of $2.6 million [31]. A second Army study was performed in 1998.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Vaccine-preventable adenoviral respiratory illness in US military recruits, 1999–2004☆

Russell

Hawksworth

Ryan

et al. 2006

Vaccine

126

109

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Background and Methods: The high burden of respiratory infections in military populations is well documented throughout history. The primary pathogen responsible for morbidity among US recruits in training was shown to be adenovirus. Highly efficacious oral vaccines were used for 25 years, but vaccine production ceased in 1996, and available stores were depleted by early 1999. Surveillance for acute febrile respiratory illness was performed at eight military recruit training sites throughout the United States from July 1999 through June 2004 to document rates after loss of the vaccines. Laboratory diagnoses complimented the surveillance efforts.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vaccine-preventable adenoviral respiratory illness in US military recruits, 1999–2004☆

Russell

Hawksworth

Ryan

et al. 2006

Vaccine

126

109

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“…[41][42][43] Although the vaccine had been highly successful in preventing the adenovirus outbreaks that had previously plagued military recruits, Wyeth ceased production in 1996 after the Department of Defense balked at Wyeth's request for additional funding to upgrade their production facilities. Therefore, manufacturing costs were paramount when the Department of Defense sought and eventually identified additional manufacturers.…”

Section: Example: West Nile Virus (Wnv) Vaccinementioning

confidence: 99%

Pricing of new vaccines

Lee

McGlone

2010

Human Vaccines

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“…During the 1950s and 1960s, up to 10% of recruits were infected with adenovirus, and these pathogens were responsible for approximately 90% of pneumonia hospitalizations (HILLEMAN, 1958;MILLER et al, 1963). During the fall and winter seasons, specially in basic training camps, adenovirus caused widespread morbidity that overwhelmed medical resources, disrupted military training, and caused significant economic loss (COLLIS et al, 1973). This scenario changed dramatically after 1971 with the introduction of an oral attenuated adenovirus vaccine against serotypes 4 (specie E) and 7 (specie B) (GAYDOS & GAYDOS, 1995).…”

Section: Abstract: Adenovirus; Respiratory Infections; Epidemiologymentioning

confidence: 99%

Adenoviruses isolated from civilian and military personnel in the city of Rio de Janeiro, Brazil

Albuquerque

Silva

Soares

et al. 2003

Rev. Inst. Med. trop. S. Paulo

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SUMMARYAdenovirus are important pathogen primarily associated to respiratory infections of children and military personnel, even though it is also associated to cases of conjunctivitis and keratoconjunctivitis. We analyzed respiratory secretion collected from subjects with and without respiratory infection symptoms, being 181 civilians and 221 military subjects. The samples were inoculated in HEp-2 and/or A549 tissue cultures for viral isolation. Samples presenting cytopathogenic effect (CPE) in any tissue culture were tested by a polymerase chain reaction (PCR) assay to confirm adenovirus isolation. The isolates confirmed as adenovirus were further analyzed by restriction endonuclease assay for determination of viral species. Three isolates were identified as specie A (two from civilian and one from military), one isolate from military was identified as specie C, and one isolate from civilian was identified as specie D. For two isolates the specie could not be identified. KEYWORDS: Adenovirus; Respiratory infections; Epidemiology.Human adenovirus comprises 51 serotypes classified into the genera Mastadenovirus of the Adenoviridae family, and are divided in six species (formerly subgenera) designated from A to F (BENKÖ et al., 1999;DE JONG et al., 1999, HORWITZ, 2001). The adenoviruses were first isolated and characterized as viral agent by two groups who were searching for the etiologic agents of acute respiratory infections (ROWE et al., 1953;HILLEMAN & WERNER, 1954). Besides respiratory diseases, which includes acute respiratory disease of the military recruits, acute febrile pharyngitis, pharingoconjuctival fever, and pneumonia, the adenoviruses have been associated to a variety of clinical syndromes, such as epidemic keratoconjunctivitis, acute hemorrhagic cystitis, hepatitis and gastroenteritis (HORWITZ, 2001). Recently, the detection of adenovirus genome was described in cases of myocarditis (PAUSCHINGER et al., 1999), sudden infant death associated to myocarditis and pericartitis (SHIMIZU et al., 1995), toxic shock-like syndrome (PRICE et al., 2001), and unexplained deaths (PERKINS et al., 1996). Isolation of adenovirus from patients with central nervous system manifestations such of fatal acute flaccid paralysis (CARDOSA et al., 1999) and encephalitis with cerebral edema have also been described (CHATTERJEE et al., 2000).Epidemiologic studies initiated by the Commission of Acute Respiratory Disease of the U.S. Armed Forces confirmed that the adenoviruses were the cause of a large number of respiratory syndromes among military recruits (GINSBERG et al., 1955;DINGLE & LANGMUIR, 1968). Because of crowded living conditions, stressful working environment, and exposure to respiratory pathogens in diseaseendemic areas, military trainees and newly mobilized troops are at particularly high risk for respiratory disease epidemics (GRAY et al., 1994;GAYDOS & GAYDOS, 1995). During the 1950s and 1960s, up to 10% of recruits were infected with adenovirus, and these pathogens were responsible for approximately 90% of ...

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Adenovirus Vaccines in Military Recruit Populations: A Cost-Benefit Analysis

Cited by 29 publications

References 9 publications

Vaccine-preventable adenoviral respiratory illness in US military recruits, 1999–2004☆

Vaccine-preventable adenoviral respiratory illness in US military recruits, 1999–2004☆

Pricing of new vaccines

Adenoviruses isolated from civilian and military personnel in the city of Rio de Janeiro, Brazil

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