Adenovirus-mediated Recombinant Human Bone Morphogenetic Protein-7 Expression Promotes Differentiation of Human Dental Pulp Cells

Up-regulation of Nucleotide-binding Oligomerization Domain 1 in Inflamed Human Dental Pulp

“…HDPFs were established as previously described (19). Briefly, after extraction, teeth were split, and the dental pulp tissue was aseptically removed with forceps.…”

Simvastatin Induces the Odontogenic Differentiation of Human Dental Pulp Stem Cells In Vitro and In Vivo

“…In an experimental setting, several growth factors were investigated and proved to induce odontogenic differentiation of dental pulp cells in vitro and to accelerate dentin formation in vivo (7)(8)(9)(10)(11)(12). Among them, bone morphogenetic proteins (BMPs) were considered to be promising growth factors capable of promoting odontogenic differentiation (9)(10)(11).…”

“…Among them, bone morphogenetic proteins (BMPs) were considered to be promising growth factors capable of promoting odontogenic differentiation (9)(10)(11). However, the possibility of unexpected side effects and the production cost can be obstacles for their clinical application.…”

Dental Pulp Stem Cell Niche

“…rhBMP-2, -4, and -7 are capable of stimulating the differentiation of DPSCs and form the regenerative dentin [69][70][71]. When reconstituted in a collagen gel drop and stimulated by microencapsulated and control-released BMP4, BMP7 and Wnt3a, postnatal dental epithelial and mesenchymal cells can orchestrate de novo formation of enamel-and dentin-like tissues in two integrated layers in vivo [72,73].…”