2005
DOI: 10.1158/0008-5472.can-05-0829
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Adenovirus-Mediated Overexpression of REIC/Dkk-3 Selectively Induces Apoptosis in Human Prostate Cancer Cells through Activation of c-Jun-NH2-Kinase

Abstract: Alteration in genes which takes place during malignant conversion and progression could be potential targets for gene therapy. We previously identified REIC/Dkk-3 as a gene whose expression is reduced in many human cancers. Here, we showed that expression of REIC/Dkk-3 was consistently reduced in human prostate cancer tissues in a stagedependent manner. Forced expression of REIC/Dkk-3 induced apoptosis in human prostate cancer cell lines lacking endogenous REIC/Dkk-3 expression but not in REIC/Dkk-3-proficient… Show more

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Cited by 175 publications
(335 citation statements)
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“…However, this does not sufficiently exclude other mechanisms, since a number of apoptotic signaling pathways are involved in the progression of lung cancer (37,38). In another respect, Dkk3 regulates cell proliferation and apoptosis in a complex manner, as Dkk3 may also directly or indirectly modulate apoptosis via the mitochondrial pathway and c-Jun N-terminal kinase (JNK) signaling pathway (44)(45)(46). The genome-wide assay has also shown that Wnt inhibition by β-catenin knockout alters over 130 gene expressions and regulates the PI3K/Akt, NF-κB and p53 pathways which play a crucial role in cell apoptosis (47).…”
Section: Discussionmentioning
confidence: 99%
“…However, this does not sufficiently exclude other mechanisms, since a number of apoptotic signaling pathways are involved in the progression of lung cancer (37,38). In another respect, Dkk3 regulates cell proliferation and apoptosis in a complex manner, as Dkk3 may also directly or indirectly modulate apoptosis via the mitochondrial pathway and c-Jun N-terminal kinase (JNK) signaling pathway (44)(45)(46). The genome-wide assay has also shown that Wnt inhibition by β-catenin knockout alters over 130 gene expressions and regulates the PI3K/Akt, NF-κB and p53 pathways which play a crucial role in cell apoptosis (47).…”
Section: Discussionmentioning
confidence: 99%
“…Hence, DKK3 is also known as 'REIC' (Reduced Expression in Immortalized Cells) . Furthermore, DKK3 overexpression suppresses tumor cell growth (Hoang et al, 2004;Abarzua et al, 2005;Lodygin et al, 2005;Kawano et al, 2006). While hypermethylation of human DKK3 correlates with …”
Section: Dkks and Cancermentioning
confidence: 99%
“…The second class including the Dkk family exerts inhibition by endocytosis of co-receptors LRP5/6 (Kawano et al, 2003). Several Wnt antagonists, including Frzb/sFRP3 and Dkk-3, function as tumor suppressors (Zi et al, 2005;Guo et al, 2008;Abarzua et al, 2005;Rubin et al, 2010;Gurney et al, 2012). WIF-1 is a unique Wnt antagonist, structurally distinct from sFRP and Dkk families, which contains a WIF domain for Wnt binding activity and epidermal growth factor (EGF) repeats (Hsieh et al, 1999).…”
Section: The Wnt/catenin Pathway Is Very Important In Osamentioning
confidence: 99%