Adenovirus infections in Bordeaux University Hospital 2008–2010: Clinical and virological features

Berciaud, Sylvie; Rayne, Fabienne; Kassab, Somar; Jubert, Charlotte; Corte, Muriel Faure-Della; Salin, Franck; Wodrich, Harald; Lafon, Marie‐Edith

doi:10.1016/j.jcv.2012.04.009

Cited by 47 publications

(37 citation statements)

References 37 publications

(80 reference statements)

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“…HAdV-7 and HAdV-3 of species B comprised the most prevalent types and presented throughout the duration of the study. Although these results were consistent with previous reports from Korea and Argentina [22,28,29], investigations from Croatia, Peru, Canada, France showed that species C predominated [1,25,26,30]. This difference in type prevalence may be attributed to difference in regions, year of study, and population recruited.…”

Section: Discussionsupporting

confidence: 92%

Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China, 2007 to 2012

et al. 2015

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BackgroundHuman adenoviruses (HAdV) play a significant role in pediatric respiratory tract infections. To date, over 60 types of HAdV have been identified. Here, HAdV types are characterized in children in the Beijing area with acute lower respiratory tract infections (ALRTIs) and the clinical features and laboratory findings of hospitalized HAdV-infected cases are described.MethodsRespiratory specimens were collected from pediatric patients with ALRTIs in the emergency department or from those admitted to Beijing Children’s Hospital between March 2007 and December 2012. Infections with common respiratory viruses were determined by PCR or RT-PCR. HAdV positive samples were further typed by PCR and sequencing.ResultsAmong 3356 patients with ALRTIs, 194 (5.8 %) were found to have HAdV infection. HAdV infection was primarily confined to children (88.35 %) less than 5 years of age. A total of 11 different types of HAdV were detected throughout the study period, with HAdV-B7 (49.0 %) and HAdV-B3 (26.3 %) as the most prevalent types, followed by HAdV-C2 (7.7 %) and HAdVC1 (4.6 %). Newly emerging and re-emergent types or variants, HAdV-B55 (n = 5), HAdV-C57 (n = 3), and HAdV-B14p1 (n = 1), were identified. Results also included the reported first case of co-infection with HAdV-C2 and HAdV-C57. Clinical entities of patients with single HAdV infection (n = 49) were similar to those with mixed HAdV/respiratory syncytial virus (RSV) infections (n = 41). Patients with HAdV-B7 infection had longer duration of fever and higher serum levels of muscle enzymes than HAdV-B3-infected patients.ConclusionsDuring the study period, HAdV-B7 and HAdV-B3 were the predominant types identified in pediatric ALRTIs. HAdV-B7 infection tends to have more severe clinical consequences. The presence of newly emerging types or variants and co-infection with different types of HAdV highlights the need for constant and close surveillance of HAdV infection.

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Section: Discussionsupporting

confidence: 92%

Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China, 2007 to 2012

et al. 2015

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“…54 No clear seasonality, although cases may spike in some months. 55 A number of outbreaks caused by adenovirus have been reported. Some examples include reports of outbreaks in military personnel, 56 psychiatric care facility, 57 and ICU.…”

Section: Adenovirusmentioning

confidence: 99%

Influenza and Viral Pneumonia

Cavallazzi

Ramirez

2018

Clinics in Chest Medicine

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“…HAdV infections are readily transmittable and, in some instances, highly contagious. Although the clinical courses are usually mild and self-limiting, infections may cause local outbreaks with severe courses, occasionally leading to a lethal outcome even in immunocompetent individuals (22)(23)(24)(25)(26). However, adenoviruses play a particularly important role in patients with strongly impaired immune responses, in whom viral disease is associated with high morbidity and mortality, and infections in this setting are an important focus of the present review.…”

mentioning

confidence: 99%

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

2014

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SUMMARY Human adenoviruses (HAdVs) are an important cause of infections in both immunocompetent and immunocompromised individuals, and they continue to provide clinical challenges pertaining to diagnostics and treatment. The growing number of HAdV types identified by genomic analysis, as well as the improved understanding of the sites of viral persistence and reactivation, requires continuous adaptions of diagnostic approaches to facilitate timely detection and monitoring of HAdV infections. In view of the clinical relevance of life-threatening HAdV diseases in the immunocompromised setting, there is an urgent need for highly effective treatment modalities lacking major side effects. The present review summarizes the recent progress in the understanding and management of HAdV infections.

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Adenovirus infections in Bordeaux University Hospital 2008–2010: Clinical and virological features

Cited by 47 publications

References 37 publications

Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China, 2007 to 2012

Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China, 2007 to 2012

Influenza and Viral Pneumonia

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

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