Adenovirus infection in children hospitalized with pneumonia in Guangzhou, China

Zou, Lirong; Liu, Yi; Jian-xiang, YU; Song, Yinchao; Liang, Lijun; Guo, Qianfang; Zhuang, Xue; Zhang, Yunqiang; Kang, Min; Wu, Jie

doi:10.1111/irv.12782

Cited by 29 publications

(42 citation statements)

References 24 publications

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“…The present study recorded the epidemiological distribution of circulating HAdV strains among hospitalized patients with respiratory tract infections (RTIs) between 2017 and 2019 in Guangzhou City, China. In this study, the overall positive rate of HAdV was 2.4%, which is consistent with the positive rate (2.0%-6.1%) found in hospitalized patients with acute viral respiratory infection in other recent reports [3,[19][20][21]. However, two previous studies conducted in the Northern part of China showed a higher HAdV prevalence (10.4%-20.1%) than our study [22,23].…”

Section: Discussionsupporting

confidence: 92%

“…Regarding patient demographic data, there was no signi cant difference observed in HAdV detections between genders in this study. This is consistent with the ndings of previous studies conducted in China [3,20]. However, this was in contrast to some previous reports that male children were more likely to be infected with HAdV [24,25].…”

Section: Discussionsupporting

confidence: 92%

“…However, this was in contrast to some previous reports that male children were more likely to be infected with HAdV [24,25]. The highest HAdV-positive rate was observed among children between the ages of 5 and 10 years, which is similar to the ndings of a recent study in the same city [3]. However, most previous reports found that the HAdV infections occurred more often among children under ve years of age [19,[26][27][28].…”

Section: Discussioncontrasting

confidence: 62%

“…HAdV is a highly contagious pathogen that causes various clinical illnesses, including upper and lower respiratory infections, bronchitis, pneumonia, conjunctivitis, and acute gastroenteritis [3]. All age groups of people are susceptible to HAdV infections, while children, immunocompromised patients, cardiovascular disease patients, and military trainees are at a higher risk for developing severe disease [3][4][5]. It has been reported that HAdV is responsible for at least 5-10% of pediatric and 1-7% of adult respiratory tract infections (RTIs) [6].…”

Section: Introductionmentioning

confidence: 99%

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Molecular Typing of Human Adenovirus Infection among Hospitalized Patients with Respiratory Tract Infections in Guangzhou, China

Wang¹,

Umar²,

Qin³

et al. 2021

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Background Human Adenoviruses (HAdVs) cause a wide array of illnesses in all age groups. They particularly cause frequent morbidity among children. In China, human adenovirus types 3, 4, 7, 11, 14, 21, and 55 have caused at least seven outbreaks since 2000. However, limited studies are available regarding the epidemiological patterns and diversity of HAdVs types among hospitalized patients with respiratory tract infections (RTIs). Methods To understand the epidemiology and type distribution of HAdV infections associated with RTIs in China, nasal swab (NS) clinical samples were collected from 4129 patients in a Guangzhou hospital between August 2017 and October 2019. PCR, sequencing, and phylogenetic analysis were performed on these specimens to identify HAdV virus types. Results HAdV was detected in 99 (2.4%) of the 4,129 NS specimens, with the highest HAdV prevalence (6.3%) found in children between the ages of 5 and 10 years. Among HAdV-positive specimens, the most prevalent genotypes identified were HAdV-B3 (55.6%) and HAdV-B7 (25.3%). The most common symptoms in the HAdV-infected patients were fever (100%), cough (80.8%) and rhinorrhea (71.8%). HAdV infections were detected throughout the year with a relatively higher prevalence in summer. Conclusion All ages suffer adenovirus infections, but young children are at greatest risk. These study data demonstrate that at least three species of HAdVs (species B, C, and E) are circulating in Guangzhou City, China. As antiviral therapies and type-specific vaccines become available, such epidemiological data will be useful in guiding therapy and public health interventions.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

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Molecular Typing of Human Adenovirus Infection among Hospitalized Patients with Respiratory Tract Infections in Guangzhou, China

Wang¹,

Umar²,

Qin³

et al. 2021

Preprint

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“…The most commonly isolated serotype was HAdV-7 in children with pneumonia, but HAdV-3 was the most common serotype in children with bronchitis, tonsillitis, and URTI. Many studies have shown that HAdV pneumonia is predominantly caused by HAdV-3 and -7 ( Zou et al, 2020 ). HAdV-2 is the most common type isolated in children with tonsillitis.…”

Section: Discussionmentioning

confidence: 99%

The Epidemiology, Molecular, and Clinical of Human Adenoviruses in Children Hospitalized With Acute Respiratory Infections

et al. 2021

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IntroductionHuman adenovirus (HAdV) is a common pathogen in children with acute respiratory infections (ARIs). The aim was to describe the epidemiology, molecular, and clinical characteristics of HAdV among children hospitalized with ARIs in Wenzhou in southeastern China.MethodologyFrom January 2018 to December 2019, nasopharyngeal swab or sputum specimens were prospectively collected from hospitalized children with ARIs. HAdV was detected using direct immunofluorescence. We used a multiplex PCR assay combined with capillary electrophoresis targeting the hexon gene’s hypervariable region to identify HAdV types 1, 2, 3, 4, 5, 7, 14, 21, 37, 40, 41, and 55. We analyzed the epidemiological, molecular, and clinical data according to the HAdV type.ResultsHAdVs were detected in 1,059 (3.5%) of the total of 30,543 children tested. A total of 947 cases with monotype HAdV identified by the PCR assay were included in the analysis. HAdV-3 (415/947, 43.8%), HAdV-7 (318/947, 33.6%), HAdV-2 (108/947, 11.4%), and HAdV-1 (70/947, 7.4%) were the predominant types. Of the 550 (58.1%) cases detected from December 2018 to August 2019, HAdV-3, and HAdV-7 were the main types. The main diagnoses included 358 cases of pneumonia, 232 cases of tonsillitis, 198 cases of bronchitis, and 159 cases of upper respiratory tract infection (URTI). Among children with pneumonia the main types were HAdV-7 (51.1%), HAdV-3 (36.9%), and HAdV-1 (2.2%). Among children with bronchitis, the main types were HAdV-3 (48.0%), HAdV-7 (28.3%), and HAdV-2 (10.6%). Among children with URTIs, the main types were HAdV-3 (49.7%), HAdV-7 (22.6%), and HAdV-2 (13.2%). Among children with tonsillitis, the main types were HAdV-3 (47.4%), HAdV-2 (22.4%), and HAdV-7 (18.5%). In total, 101 (55.2%) patients required supplemental oxygen, 15 (8.2%) required critical care, and 1 child (0.5%) with HAdV-7 pneumonia died.ConclusionHAdV-3 -7, -2, and -1 were the predominant types identified in hospitalized children with ARIs in Wenzhou. From December 2018 to August 2019, there were outbreaks of HAdV-3 and -7. There were significant differences in HAdV types among children with pneumonia, tonsillitis, bronchitis, and URTI. HAdV-7 can cause more severe pneumonia in children than HAdV-3.

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An outbreak of acute respiratory disease caused by HAdV‐55 in Beijing, China, 2020

Liu

Xiang

et al. 2022

Journal of Medical Virology

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Human adenoviruses (HAdVs) can cause acute respiratory diseases (ARDs) worldwide, and HAdV-55 is a reemergent pathogen in recent years. In the study, we investigated an outbreak of ARD at a school due to HAdV-55 in Beijing, China, during the early outbreak of coronavirus disease 2019 . The epidemic prevention team was dispatched to the school to collect epidemiologic data and nasopharyngeal samples. Then, real-time reverse transcription polymerase chain reaction (PCR) and multiplex PCR assays were used to detect severe acute respiratory syndrome coronavirus 2 and other respiratory pathogens, respectively.One representative HAdV-55 isolate was selected and submitted for whole-genome sequencing using a MiSeq system and the whole-genome phylogenetic tree was conducted based on the maximum likelihood method. The outbreak lasted from January 27 to February 6, 2020, and 108 students developed fever, among whom 60 (55.56%) cases were diagnosed with HAdV-55 infection in the laboratory using realtime PCR and 56 cases were hospitalized. All the confirmed cases had a fever and 11 cases (18.33%) presented with a fever above 39°C. Other main clinical symptoms included sore throat (43.33%) and headache (43.33%). We obtained and assembled the full genome of one isolate, BJ-446, with 34 761 nucleotides in length. HAdV-55 isolate BJ-446 was 99.85% identical to strain QS-DLL, which was the first HAdV-55 strain in China isolated from an ARD outbreak in Shanxi in 2006. One and four amino acid mutations were observed in the hexon gene and the coding region of L2 pV 40.1 kDa protein, respectively. We identified the first HAdV-55 infection associated with the ARD outbreak in Beijing since the emergence of COVID-19. The study suggests that improved surveillance of HAdV is needed, although COVID-19 is still prevalent in the world.

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Adenovirus infection in children hospitalized with pneumonia in Guangzhou, China

Cited by 29 publications

References 24 publications

Molecular Typing of Human Adenovirus Infection among Hospitalized Patients with Respiratory Tract Infections in Guangzhou, China

Molecular Typing of Human Adenovirus Infection among Hospitalized Patients with Respiratory Tract Infections in Guangzhou, China

The Epidemiology, Molecular, and Clinical of Human Adenoviruses in Children Hospitalized With Acute Respiratory Infections

An outbreak of acute respiratory disease caused by HAdV‐55 in Beijing, China, 2020

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