Adenovirus Infection and Childhood Intussusception

Bhisitkul, Donna M.; Todd, Kathleen; Listernick, Robert

doi:10.1001/archpedi.1992.02160230089026

Cited by 36 publications

(32 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They conducted a retrospective case‐control study with subgroup analysis among patients with adenovirus infection, which only HAdV‐C remained statistically associated with intussusception. The studies from the United States of America [Bhisitkul et al, ], Taiwan [Hsu et al, ] and from Japan [Okimoto et al, ] also suggest a causal association of non‐enteric types of adenoviruses in patients with intussusception. Besides adenovirus, the prevalence of norovirus gastroenteritis has also increased recently.…”

Section: Discussionmentioning

confidence: 99%

Adenovirus infection: A potential risk for developing intussusception in pediatric patients

et al. 2016

View full text Add to dashboard Cite

The pathogenesis of intussusception without obvious anatomical leading points remains unclear. The objective of this study was to determine a feasibility of association between certain gastroenteritis viruses and intussusception. This was a prospective cohort study. Forty intussusception cases and 136 acute gastroenteritis controls with comparable age and gender were separately consecutively enrolled and relevant clinical data of both groups were recorded. The clinical specimens collected from all patients were screened for adenovirus, rotavirus, norovirus, and astrovirus by PCR and RT-PCR using specific primers. The genomes of detected viruses were characterized further to identify their genotypes by nucleotide sequencing. In 40 intussusception cases, adenovirus, rotavirus, and norovirus were detected in 12 (30.0%), 2 (5.0%), and 2 (5.0%), respectively while astrovirus was undetectable. In contrast, 136 acute gastroenteritis patients, adenovirus, rotavirus, and norovirus were detected in 11 (8.1%), 24 (17.7%), and 24 (17.7%) patients, respectively and again astrovirus was undetectable. The detection of adenovirus in intussusception patients was significantly higher than those in the control group (P < 0.001) with an odd ratio of 4.87 (95%CI: 1.95, 12.16). Interestingly, molecular analysis of adenovirus genome demonstrated that all of adenovirus detected in intussusception patients belonged to adenovirus C. This could be a potential risk factor or pathogenesis for developing intussusception in the cases of those without apparent anatomical leading points. J. Med. Virol. 88:1930-1935, 2016. © 2016 Wiley Periodicals, Inc.

show abstract

Section: Discussionmentioning

confidence: 99%

Adenovirus infection: A potential risk for developing intussusception in pediatric patients

et al. 2016

View full text Add to dashboard Cite

show abstract

“…9 Respiratory adenovirus infection has been associated with some cases of intussusception through the development of lymphoid hyperplasia in the gut. [11][12][13][14] The role of wild-type rotavirus as a causative agent for intussusception has not been well-defined. Epidemiologic data do not suggest that wild-type rotavirus infection is a significant cause of intussusception.…”

Section: Discussionmentioning

confidence: 99%

Intussusception Among Recipients of Rotavirus Vaccine: Reports to the Vaccine Adverse Event Reporting System

et al. 2001

View full text Add to dashboard Cite

ABSTRACT. Background. Rotavirus vaccine was licensed on August 31, 1998, and subsequently recommended for routine use among infants. To assess rare adverse events, postlicensure surveillance was conducted.Objective. To describe the cases of intussusception among rotavirus vaccine recipients reported to the Vaccine Adverse Event Reporting System from October 1998 through December 1999. Setting and Participants. Infants vaccinated with rotavirus vaccine in the United States.Outcome Measures. Intussusception confirmed by radiology, surgery, or autopsy report with medical record documentation or confirmed by a primary health care provider.Results. There were 98 confirmed cases of intussusception after vaccination with rotavirus vaccine reported to the Vaccine Adverse Event Reporting System; 60 of these developed intussusception within 1 week after vaccination. Based on calculations using vaccine distribution data and intussusception incidence rates from 2 separate databases, an estimated 7 to 16 cases would have been expected to occur in the week after vaccination by chance alone.Conclusion. Using a passive surveillance system for vaccine adverse events, we observed at least a fourfold increase over the expected number of intussusception cases occurring within 1 week of receipt of rotavirus vaccine. Other studies were initiated to further define the relationship between rotavirus vaccine and intussusception. In light of these and other data, the rotavirus vaccine manufacturer voluntarily removed its product from the market, and the recommendation for routine use of rotavirus vaccine among US infants has been withdrawn. T he live, oral, rhesus-human rotavirus reassortant-tetravalent vaccine (RRV-TV) was licensed for use in the United States on August 31, 1998. It was subsequently recommended for routine use in infants in a 3-dose series given at 2, 4, and 6 months of age. 1,2 This recommendation was based on the morbidity and economic burden of severe dehydrating rotavirus gastroenteritis among infants and young children. 1 In prelicensure clinical trials, 5 cases of intussusception were noted among 10 054 vaccinees who had received 1 of 3 different formulations of rotavirus vaccine. Two of these 5 cases received RRV-TV. All 5 intussusception cases occurred after either dose 2 or 3. The cases occurred 6 to 51 days after rotavirus vaccination; 3 of these cases occurred on days 6 or 7. In contrast, 1 case of intussusception was noted among 4633 controls. 3 The difference in the proportion of children who developed intussusception in the vaccinated and unvaccinated groups was not statistically significant. Although there was insufficient evidence to conclude that the association between RRV-TV and intussusception was causal rather than temporal, intussusception was noted in the package insert, and postlicensure surveillance for intussusception was recommended by the Advisory Committee on Immunization Practices (ACIP). 1 Distribution of RRV-TV commenced in October 1998. After vaccine introduction, reports to the Vaccine ...

show abstract

“…It is the most frequent cause of acute abdominal emergency in the first two years of life but rarely occurs in adults [1]. Most cases of IS are considered idiopathic although several authors have suggested links with various infectious agents [2-4]. An association between natural rotavirus (RV) infection and IS has not been found [3,5,6].…”

Section: Introductionmentioning

confidence: 99%

A multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data

Sáez-Llorens

Velázquez

López³

et al. 2013

BMC Gastroenterol

View full text Add to dashboard Cite

BackgroundIntussusception (IS) is a form of acute intestinal obstruction that occurs mainly in infants and is usually of unknown cause. An association between IS and the first licensed rotavirus vaccine, a reassortant-tetravalent, rhesus-based rotavirus vaccine (RRV-TV), led to the withdrawal of the vaccine. New rotavirus vaccines have now been developed and extensively studied for their potential association with IS. This study aimed to describe the epidemiology and to estimate the incidence of IS in Latin American infants prior to new vaccine introduction.MethodsChildren under 2 years of age representing potential IS cases were enrolled in 16 centers in 11 Latin American countries from January 2003 to May 2005. IS cases were classified as definite, probable, possible or suspected as stated on the Brighton Collaboration Working Group guidelines.ResultsFrom 517 potential cases identified, 476 (92%) cases were classified as definite, 21 probable, 10 possible and 10 suspected for intussusception. Among the 476 definite IS cases, the median age at presentation was 6.4 months with 89% of cases aged <1 year. The male to female ratio was 1.5:1. The incidence of definite IS per 100,000 subject-years ranged from 1.9 in Brazil to 62.4 in Argentina for children <2 years of age, and from 3.8 in Brazil to 105.3 in Argentina for children aged <1 year. Median hospital stay was 4 days with a high prevalence of surgery as the primary treatment (65%). Most cases (88%) made a complete recovery, but 13 (3%) died. No clear seasonal pattern of IS cases emerged.ConclusionsThis study describes the epidemiology and estimates the incidence of IS in Latin American infants prior to the introduction of new rotavirus vaccines. The incidence of IS was found to vary between different countries, as observed in previous studies.Trial registrationClinical study identifier 999910/204 (SERO-EPI-IS-204)

show abstract

Adenovirus Infection and Childhood Intussusception

Cited by 36 publications

References 10 publications

Adenovirus infection: A potential risk for developing intussusception in pediatric patients

Adenovirus infection: A potential risk for developing intussusception in pediatric patients

Intussusception Among Recipients of Rotavirus Vaccine: Reports to the Vaccine Adverse Event Reporting System

A multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data

Contact Info

Product

Resources

About