Adenovirus in Blood Clots from Cases of Infectious Hepatitis

Hartwell, W. V.; Love, G. J.; Eidenbock, Marie P.

doi:10.1126/science.152.3727.1390

Cited by 13 publications

(5 citation statements)

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“…Statistically, the chances of such association being accidental are 1:12,000, yet on clinicoepidemfological evidence the H non-proven cases of hepatitis were considered to be due to HAV. Similar association of adenovirus with clinical cases of hepatitis has been reported by Davis (1961), and Hartwell, Love and Eidenbock (1966), and their possible significance has been extensively discussed by Zuckerman (1970).…”

supporting

confidence: 66%

Attempts to Isolate a Parvovirus From Faecal Specimens of Patients With Hepatitis A

Wosu

Locarnini

Johnson

1978

Aust J Exp Biol Med

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supporting

confidence: 66%

Attempts to Isolate a Parvovirus From Faecal Specimens of Patients With Hepatitis A

Wosu

Locarnini

Johnson

1978

Aust J Exp Biol Med

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“…n.s., not statistically significant. uated cases) from the blood clots of patients with infectious hepatitis (14). In a later study of the epidemiology of simian immunodeficiency virus, Gravell et al reported the isolation of Ad type 11 from plasma, urine, feces, and kidneys of monkeys with and without signs of simian acquired immune deficiency syndrome (11).…”

Section: Discussionmentioning

confidence: 99%

Fiber Shaft-Chimeric Adenovirus Vectors Lacking the KKTK Motif Efficiently Infect Liver Cells In Vivo

Paolo

Kalyuzhniy

Shayakhmetov

2007

J Virol

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The molecular mechanisms governing the infectivity of adenovirus (Ad) toward specific cell and tissue types in vivo remain poorly understood. The direct Ad binding to hepatic heparan sulfate proteoglycans via the KKTK motif within the fiber shaft domain was suggested to be the major mechanism of Ad liver cell infection in vivo. Here, we describe the generation and in vitro and in vivo infectivity studies of Ad5-based vectors possessing long Ad31-or Ad41-derived fiber shaft domains, which lack the KKTK motif. We found that all the critical early steps of Ad infection, including attachment to the cellular receptor, internalization, and virus genome transfer into the nucleus, occurred with similar levels of efficiency for fiber shaft-chimeric vectors and unmodified Ad5. Upon intravenous delivery into mice, fiber shaft-chimeric vectors accumulated in liver tissue, transduced liver cells, and induced the production of proinflammatory cytokines (tumor necrosis factor alpha and interleukin-6) and the chemokine monocyte chemoattractant protein 1 at levels indistinguishable from those observed for Ad5. Thus, our data provide evidence that the Ad5 fiber shaft amino acid sequence does not play any substantial role in determining adenovirus infectivity toward hepatic cells in vivo. The data obtained contribute to improving our understanding of the molecular mechanisms determining Ad infectivity and biodistribution in vivo and may aid in designing novel Ad-based vectors for gene therapy applications.

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“…In the haemagglutination test for rubella virus, the proportion of positive sera Although it cannot be excluded, the possibility of a direct involvement of adenovirus type 5 in the aetiology of infectious hepatitis, -as for example, in canine infectious hepatitis in which the liver damage is caused by the multiplication of an adenovirus -appears unlikely despite the various isolations of adenoviruses from cases of the disease (Davis, 1961;Hatch & Siem, 1966;Hartwell, Love & Eidenbock, 1966). An indirect action of adenovirus is perhaps more probable; this could arise from adenovirus multiplication elsewhere than in the liver, with consequent damage by adenovirus antigen(s), or antigen(s)/antibody complexes.…”

Section: Resultsmentioning

confidence: 99%

Antibodies against adeno-, cytomegalo- and rubella viruses in Australia-antigen-negative sera from patients with infectious hepatitis

Alwen

Emmerson

1974

J. Hyg.

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SUMMARYAntibodies neutralizing adenovirus type 5 were found in all of 50 pairs (100 %) of sera from patients with acute icteric infectious hepatitis. The incidence in sera from the general population was 57 %. No differences in mean titre or in proportion of positive sera were found in the same sera tested for complement-fixing antibodies to cytomegalovirus and for antibodies to rubella virus haemagglutinin. The results can be interpreted as supporting the involvement, either direct or indirect, of adenovirus in the aetiology of infectious hepatitis; but could also be due to a non-specific anamnestic enhancement of the production of antibody to adenovirus, or to coincidental infection with adenovirus and the agent of infectious hepatitis.

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Adenovirus in Blood Clots from Cases of Infectious Hepatitis

Abstract: Adenovirus type 5 was isolated from blood clots from 27 of 30 sporadic cases of infectious hepatitis. Only one isolation of virus, also adenovirus 5, was made from blood clots from 70 persons with no known contact with infectious hepatitis.

Cited by 13 publications

References 0 publications

Attempts to Isolate a Parvovirus From Faecal Specimens of Patients With Hepatitis A

Attempts to Isolate a Parvovirus From Faecal Specimens of Patients With Hepatitis A

Fiber Shaft-Chimeric Adenovirus Vectors Lacking the KKTK Motif Efficiently Infect Liver Cells In Vivo

Antibodies against adeno-, cytomegalo- and rubella viruses in Australia-antigen-negative sera from patients with infectious hepatitis

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