Adenovirus and miRNAs

Carnero, Elena; Sutherland, James D.; Fortes, Puri

doi:10.1016/j.bbagrm.2011.05.004

Cited by 20 publications

(22 citation statements)

References 107 publications

(169 reference statements)

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“…4) (Andersson et al, 2005;Xu et al, 2009). The AS-CD fragment could not be detected in one study using probes specific to the Apical Stem region, suggesting it may be unstable (Aparicio et al, 2006;Carnero et al, 2011). However, another possibility is that the AS-CD fragment was detected due to the exceptionally stable nature of the Apical Stem structure, which might limit probe binding to this region.…”

Section: Dicer Saturationmentioning

confidence: 69%

Adenovirus VA RNA: An essential pro-viral non-coding RNA

Vachon

Conn

2016

Virus Research

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Section: Dicer Saturationmentioning

confidence: 69%

Adenovirus VA RNA: An essential pro-viral non-coding RNA

Vachon

Conn

2016

Virus Research

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“…For example, adenovirus-derived small RNAs massively produced in the late stage of infection are able to deplete Dicer expression by saturating exportin-5 and abrogating the nuclear export of exportin-5-dependent Dicer mRNA. As a result, maturation of small RNA is terminated by the virus using this strategy (1,4,7,31). Similarly, influenza virus-encoded NS1 protein has been shown to inhibit the host mRNA export pathway to produce greater permissiveness by host cells for influenza virus replication (32).…”

Section: Resultsmentioning

confidence: 99%

A Baculovirus-Encoded MicroRNA (miRNA) Suppresses Its Host miRNA Biogenesis by Regulating the Exportin-5 Cofactor Ran

Singh

Nagaraju

2012

J Virol

112

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MicroRNAs have emerged as key players in the regulation of various biological processes in eukaryotes, including host-pathogen interactions. Recent studies suggest that viruses encode miRNAs to manipulate their host gene expression to ensure their effective proliferation, whereas the host limits virus infection by differentially expressing miRNAs that target essential viral genes. Here, we demonstrate that an insect virus, Bombyx mori nucleopolyhedrosis virus (BmNPV), modulates the small-RNA-mediated defense of its host, B. mori, by encoding an miRNA (bmnpv-miR-1) that downregulates the expression of the host GTPbinding nuclear protein Ran, an essential component of the exportin-5-mediated nucleocytoplasmic transport machinery mainly involved in small-RNA transport from the nucleus to the cytoplasm. We demonstrate the sequence-dependent interaction of bmnpv-miR-1 with Ran mRNA using cell culture and in vivo assays, including RNA interference (RNAi) of Ran. Our results clearly show that bmnpv-miR-1 represses Ran, leading to reduction in the host small-RNA population, and consequently, the BmNPV load increases in the infected larvae. Blocking of bmnpv-miR-1 resulted in higher expression levels of Ran and a decrease in BmNPV proliferation. In contrast, blockage of host miRNA, bmo-miR-8, which targets the immediate-early gene of the virus and whose production was repressed upon bmnpv-miR-1 and Ran dsRNA administration, resulted in a significant increase in the virus load in the infected B. mori larvae. The present study provides an insight into one of the evasion strategies used by the virus to counter the host defense for its effective proliferation and has relevance to the development of insect virus control strategies.

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“…Interestingly, recent data support the notion that miRNAs are key players in virus-host interactions and viral pathogenesis [7,10,11,12,13,14,15,16]. The role of miRNAs in the complex regulatory network that controls both viral and host gene expression in the infected cell is starting to be elucidated for some pathogenic viruses.…”

Section: Introductionmentioning

confidence: 97%

MicroRNAs, Hepatitis C Virus, and HCV/HIV-1 Co-Infection: New Insights in Pathogenesis and Therapy

Gupta

Swaminathan

Martín-García

et al. 2012

Viruses

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MicroRNAs (miRNAs) can exert a profound effect on Hepatitis C virus (HCV) replication. The interaction of HCV with the highly liver-enriched miRNA, miR-122 represents one such unique example of viruses having evolved mechanism(s) to usurp the host miRNA machinery to support viral life cycle. Furthermore, HCV infection can also trigger changes in the cellular miRNA profile, which may ultimately contribute to the outcome of viral infection. Accumulating knowledge on HCV-host miRNA interactions has ultimately influenced the design of therapeutic interventions against chronic HCV infection. The importance of microRNA modulation in Human Immunodeficiency Virus (HIV-1) replication has been reported, albeit only in the context of HIV-1 mono-infection. The development of HCV infection is dramatically influenced during co-infection with HIV-1. Here, we review the current knowledge on miRNAs in HCV mono-infection. In addition, we discuss the potential role of some miRNAs, identified from the analyses of public data, in HCV/HIV-1 co-infection.

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Adenovirus and miRNAs

Cited by 20 publications

References 107 publications

Adenovirus VA RNA: An essential pro-viral non-coding RNA

Adenovirus VA RNA: An essential pro-viral non-coding RNA

A Baculovirus-Encoded MicroRNA (miRNA) Suppresses Its Host miRNA Biogenesis by Regulating the Exportin-5 Cofactor Ran

MicroRNAs, Hepatitis C Virus, and HCV/HIV-1 Co-Infection: New Insights in Pathogenesis and Therapy

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