Adenosquamous cell carcinoma arising from the papilla major

Ueno, Naohiko; Sano, Tomohide; Kanamaru, Taichi; Tanaka, Kenichi A.; Nishihara, Tokufumi; Idei, Yuka; Yamamoto, Masahiro; Okuno, Takehiko; Kawaguchi, Katsunori

doi:10.3892/or.9.2.317

Cited by 19 publications

(19 citation statements)

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“…When necrotic areas are present, CT will display cystic regions that may communicate with the pancreatic duct. No distinctive CT features that allow the differentiation from ductal adenocarcinoma have been reported [13,14]. Prognosis is slightly worse than in ductal cell carcinoma.…”

Section: Adenosquamous Carcinomamentioning

confidence: 99%

CT in the Differentiation of Pancreatic Neoplasms – Progress Report

Gritzmann

Macheiner²,

Hollerweger³

et al. 2004

Dig Dis

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Today, computed tomography (CT) is the most commonly used imaging method in the assessment of pancreatic tumors. The sensitivity of CT in detection of pancreatic tumors is more than 90% when direct and indirect signs are used for diagnosis. However, the potential to differentiate exocrine (non-endocrine) tumors of the pancreas is limited. CT is used in these lesions to perform an adequate staging, especially for surgical purposes. The operative resectability, primarily in regard to vessels, lymph node metastasis and hepatic metastasis, has to be assessed. Keeping in mind the limitations of this macromorphological imaging procedure, CT has the best reproducibility and overall accuracy of all imaging methods. Using multislice CT it is possible to perform non-axial reconstructions with high resolution. In functional endocrine tumors, multislice spiral CT will enhance the diagnostic capabilities, since the whole organ can be examined in thin slices, with high resolution during the rather short arterial phase of the contrast medium. Since some endocrine tumors are hypovascular, a scan during the portovenous phase is recommended too. The diagnosis of benign pancreatic tumors, like serous cystadenoma and pancreatic lipomas, is addressed. The most important pseudotumors of the pancreas are discussed.

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Section: Adenosquamous Carcinomamentioning

confidence: 99%

CT in the Differentiation of Pancreatic Neoplasms – Progress Report

Gritzmann

Macheiner²,

Hollerweger³

et al. 2004

Dig Dis

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“…Previously, the diagnosis was primarily dependent on the serum tumor markers CA19-9 and CEA as well as radiological imaging, which have low levels of sensitivity and specificity. Tissue diagnosis was also rare due to the location and size of the tumor and the risk of possible hemorrhage or bile leakage (7,8). In recent years, brush and scrape biopsy and cytological examinations of bile have been used to establish a tissue diagnosis with widespread application of ERCP;…”

Section: Discussionmentioning

confidence: 99%

“…Percutaneous fine-needle aspiration biopsy, brush and scrape biopsy and cytological examination of bile have all been used to establish a tissue diagnosis; however, the sensitivity in detecting a malignancy is low and the possibility that a benign result is unreliable Identification of bile biomarkers of biliary tract cancer through a liquid chromatography/mass spectrometry-based metabolomic method (12,13). Tissue diagnosis cannot generally be performed due to the location and size of the tumor (7). Percutaneous fine-needle aspiration biopsy cannot be used in a number of cases when the tumors are located in the hepatic hilum and accompanied by important arteries and veins (8).…”

Section: Introductionmentioning

confidence: 99%

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Identification of bile biomarkers of biliary tract cancer through a liquid chromatography/mass spectrometry-based metabolomic method

Cheng

Ding

et al. 2014

Molecular Medicine Reports

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Abstract. The incidence and mortality rate of biliary tract cancer have been increasing worldwide; however, its diagnosis and prognosis have not improved in recent years. A novel approach, termed 'metabolomics', may have the potential to be developed as an effective diagnostic tool. The present study prospectively obtained bile samples from 115 individuals, including 32 patients with biliary tract cancer, 61 patients with benign biliary tract diseases and 22 normal controls. A liquid chromatography/mass spectrometry (LC/MS)-based approach was used to investigate the differences in bile samples between the three groups, followed by multivariate statistical analysis, which included partial least squares projection to latent structures with discriminant analysis (PLS-DA) and orthogonal projection to latent structures with discriminant analysis (OPLS-DA). The metabolomic 2D score plot and 3D plot revealed clear separation between the cancer, benign and normal control groups by PLS-DA. To further address the significant difficulties in clinically differentiating between biliary tract cancer and benign biliary tract diseases, OPLS-DA was performed to distinguish between the two disease groups and to select potential biomarkers. The cancer and benign groups were well differentiated. The metabolic analysis revealed significantly lower levels of lysophosphatidylcholine, phenylalanine, 2-octenoylcarnitine, tryptophan and significantly higher levels of taurine-and glycine-conjugated bile acids in the bile from patients with biliary tract cancer compared with those in the bile from patients with benign biliary tract disease. The present study suggested that an LC/MS-based metabolomic investigation provides a potent and promising approach for discriminating biliary tract cancer from benign biliary tract diseases and the identified specific metabolites may offer potential as novel biomarkers for the early detection of biliary tract cancer.

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“…They have also been reported in other parts of the GI tract as esophagus, stomach and colon (1). To date, a very few cases of small intestinal ASCs have been reported in the literature and only 10 cases of them were duodenal ASCs involving second or third segment of duodenum (1,2,(4)(5)(6)(7)(8). Herein, we report another case of duodenal ASC that mimick subepithelial tumor on computed tomography (CT), and to the best of our knowledge, this is the first reported case of duodenal ASC arising from duodenal bulb.…”

Section: Introductionmentioning

confidence: 99%