Adenosquamous carcinoma of the right colon: A case report and review of the literature

Toumi, Omar; Hamida, Badii; Njima, Manel; Bouchrika, Amal; Ammar, Houssem; Daldoul, Amira; Zaied, Sonia; Jabra, Sadok Ben; Gupta, Rahul; Noomen, Faouzi; Zouari, Khadija

doi:10.1016/j.ijscr.2018.07.001

Cited by 14 publications

(21 citation statements)

References 7 publications

(16 reference statements)

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“…To date, standard chemotherapy for colonic ASC has not been established. FOLFOX (5-fluorouracil, leucovorin and oxaliplatin) adjuvant chemotherapy regimen has been used in some cases, but the exact effect of these drugs on prognosis is not clear ( 11 , 22 ). Based on the positive detection of HPV in some cases, anti-HPV infection may be an alternative adjuvant therapy ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

Adenosquamous carcinoma of the hepatic flexure of colon: a case report: a case report

Huang¹,

Li²,

Li³

2021

Transl Cancer Res TCR

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Adenosquamous carcinoma (ASC) is defined as a very rare subset of colorectal cancer containing both adenocarcinoma (AC) and squamous cell carcinoma (SCC) components. ASC is more aggressive for resulting in a poorer prognosis than AC alone. To date, only few cases were recorded previously. Here, we reported that a 46-year-old woman was caught by abdominal pain and hematochezia for more than 20 days and she visited the emergency room with increasing abdominal pain and vomiting for nearly one day. Physical examination indicated direct tenderness in the navel and lower abdomen distension. Laboratory examinations showed a decreased hemoglobin, increased white blood cell (WBC) count, an elevation of the serum levels of CA19-9 and carcinoembryonic antigen (CEA). Then endoscopic examination revealed a hemicircumferential mass in the ascending colon, which contained a friable and ulcerated lesion that bled easily when touched. Results of biopsy suggested a high-grade intraepithelial neoplasia. Abdominal computed tomography (CT) scanning showed some signs of neoplastic lesion that the wall of the hepatic curvature of the transverse colon is irregularly thicker, the serous surface of the diseased intestinal canal is slightly thicker, and multiple peripheral lymph nodes are enlarged. Furthermore, the multidisciplinary team (MDT) meeting thought laparoscopic right colectomy accompanied with lymphadenectomy was suitable because the clinical stage was at least stage IIIB. The post-operative pathological examination demonstrated that the tumor was composed of AC (positive for CDX-2 and CK20) and SCC (positive for CK5/6 and P63) components. Accordingly, this case was diagnosed as ASC of Stage IIIC (pT4N2M0) and the adjuvant chemotherapy FOLFOX was recommended, while unfortunately the patient refused it for personal reasons. In conclusion, radical resection remains the major treatment for colon ASC, CT scan and endoscopic examination and biopsy are useful for this pre-operative diagnosis. This case promotes the understanding of colon ASC and provides a basis for its clinical diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

Adenosquamous carcinoma of the hepatic flexure of colon: a case report: a case report

Huang¹,

Li²,

Li³

2021

Transl Cancer Res TCR

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“…Case Reports in Oncological Medicine Till date, the pathogenesis of primary SCC is unknown, and several theories have been suggested to explain the location into the gastrointestinal tract: chronic inflammatory process (ulcerative colitis, infections with Schistosoma or Entamoeba histolytica) may cause a squamous metaplasia, from which carcinomas are developed [6,8]. Other hypothesis supposes that SCC will originate from a squamous differentiation of pluripotent stem cells [6,7] or from an existing adenomas or adenocarcinomas [6,9].…”

Section: Discussionmentioning

confidence: 99%

Primary Cecal Squamous Cell Carcinoma: A Case Report of a Rare Tumor with Poor Prognosis

Mohamed

Azzakhmam

Mehdi

et al. 2021

Case Reports in Oncological Medicine

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Squamous cell carcinoma of the colon is a rare tumor and primary cecal localization is unusual. This malignant condition is marked by a worst prognosis due to early local invasion. We report a case of a 46-year-old female patient admitted to the emergency department with symptoms of peritonitis. CT scan showed a cecal tumor perforated in the retroperitoneal space. The patient underwent right hemicolectomy with D2 lymphadenectomy without intestinal anastomosis. The diagnosis of squamous cell carcinoma was confirmed by histopathological examination. Squamous cell carcinoma is a malignant tumor with poor prognosis, hence, the interest of early diagnosis and management.

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“…At present, the treatment of colon ASC is mainly referred to colon ADC, that is surgery plus adjuvant chemotherapy. Regarding postoperative chemotherapy of colon ASC, FOLFOX (consists of uorouracil, folinic acid and oxaliplatin) regimen is mostly used (13,14,15).…”

Section: Discussionmentioning

confidence: 99%

Adenosquamous Carcinoma of Sigmoid Colon: First Case Report in Pediatrics and Literature Review

Liu

et al. 2021

Preprint

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Background Colon adenosquamous carcinoma is an extremely rare cancer, especially in young people. No case of colon adenosquamous carcinoma in pediatric patient has been reported so far. Case presentation Here we present the case of a 16-year-old Chinese girl diagnosed with adenosquamous carcinoma of sigmoid colon. We performed laparoscopic sigmoidectomy with lymphadenectomy on the patient. Unfortunately, she developed liver metastasis less than 1 month after surgery. Then we implemented percutaneous radiofrequency ablation of liver mass and 4 cycles of adjuvant chemotherapy on her. However, liver metastasis recurred less than 4 months after radiofrequency ablation. The girl eventurally died in 8 months after surgical resection of sigmoid colon. As far as we know, this girl is the youngest patient with sigmoid colon adenosquamous carcinoma reported so far, and the first reported case of colon adenosquamous carcinoma in pediatrics. Conclusion Only 8 months from detection to death, this case indicates the prognosis of colon adenosquamous carcinoma is poor, and adenosquamous carcinoma of colon may even have worse prognosis in pediatrics than in adults. In addition, cases with liver metastasis have a awfully unfavorable prognosis for colon adenosquamous carcinoma patients.

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Adenosquamous carcinoma of the right colon: A case report and review of the literature

Cited by 14 publications

References 7 publications

Adenosquamous carcinoma of the hepatic flexure of colon: a case report: a case report

Adenosquamous carcinoma of the hepatic flexure of colon: a case report: a case report

Primary Cecal Squamous Cell Carcinoma: A Case Report of a Rare Tumor with Poor Prognosis

Adenosquamous Carcinoma of Sigmoid Colon: First Case Report in Pediatrics and Literature Review

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