Adenosquamous carcinoma of the prostate

Gattuso, Paolo; Carson, Henry J.; Candel, Antimo G.; Castelli, Melanie J.

doi:10.1016/0046-8177(95)90125-6

Cited by 26 publications

(14 citation statements)

References 15 publications

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“…Adenosquamous carcinoma refers to those cases with a mixture of glandular and squamous differentiation ( Figure 9). [49][50][51][52] This is also a rare neoplasm and in my experience is most often seen in association with hormonal therapy. It has been recommended that these tumors also not be Gleason graded.…”

Section: Adenosquamous and Squamous Cell Carcinomamentioning

confidence: 84%

Unusual subtypes of prostate cancer

2004

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The vast majority of prostatic tumors developing in adult males are adenocarcinomas. For the most part, variations in histology have not received specific designations and, from a practical approach, have had any specific prognostic implications handled through application of the Gleason grading system. Nonetheless, some of the adenocarcinoma variants have specific clinical features and differential diagnoses. Furthermore, there has been some controversy regarding the appropriate application of the Gleason grading scheme in these tumors. In addition, there are carcinomas that are in fact not adenocarcinomas and that should be kept as distinct entities. In this paper, the histologic variants of adenocarcinoma are reviewed with emphasis on clinicopathologic features and the clinical relevance of these subtypes. Other carcinomas that occur in the prostate gland are also discussed again with a focus on the clinicopathologic characteristics.

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Section: Adenosquamous and Squamous Cell Carcinomamentioning

confidence: 84%

Unusual subtypes of prostate cancer

2004

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“…Since the first description by Thompson, approximately 33 cases of ASCC of the prostate have been reported [3][4][5][6][7][8]. Of all ASCC cases reported in the literature, two-thirds involved patients previously treated for prostatic adenocarcinoma with hormones and/or radiation [3,[4][5][6][7][8]. The timeframe for the appearance of squamous differentiation in the carcinoma varies from 3 months to many (up to 9) years after therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Prostatic ASCC, like glandular adenocarcinomas, can spread along nerves; extend locally into periprostatic soft tissue, the bladder, and seminal vesicles; and metastasize to lymph nodes and bones [6][7][8]. However, in bones, the metastases are routinely osteolytic rather than osteoplastic.…”

Section: Discussionmentioning

confidence: 99%

“…Radical prostatectomy should be offered to those with localized prostate cancer, including healthier elderly patients with a good performance status. Some authors suggested that ASCC of the prostate responds, at least initially, to hormone therapy [4,6,7] while others reported that these tumors generally were refractory to hormone therapy [7]. However, information on response and efficacy of chemotherapy is lacking.…”

Section: Discussionmentioning

confidence: 99%

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