“…As regards the basaloid variety of squamous cell carcinoma outside the anal canal, it may arise from cloaco- genic embryologic nests, squamous metaplastic epithelium, or totipotential basal cells [12]. In mixed adenosquamous variety, Cerezo and others suggested that all such lesions be carefully evaluated by means of immunoperoxidase stains and/or electron microscopy in order to identify squamous features [20,21]. Symptoms, investigations, and assessment of patients with the divergent histologic subtypes of squamous cancer of the colon and rectum, including basaloid tumors, are similar to those of colon adenocarcinoma, as is evident in our case [5,22].…”